ID A0A0V0RJU4_9BILA Unreviewed; 622 AA.
AC A0A0V0RJU4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Putative methylenetetrahydrofolate reductase {ECO:0000313|EMBL:KRX14485.1};
GN Name=C06A8.1 {ECO:0000313|EMBL:KRX14485.1};
GN ORFNames=T07_9732 {ECO:0000313|EMBL:KRX14485.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX14485.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX14485.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX14485.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX14485.1}.
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DR EMBL; JYDL01000158; KRX14485.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0RJU4; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 2.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 2.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630}.
SQ SEQUENCE 622 AA; 71126 MW; 4C35494AA1DBE088 CRC64;
MNSSYNLQVK LKSPAYQRAV TVAKVGNPSQ QNDFGVYFEE DSFLSLMASL EAVQLKATRH
DLNSAAKKST DEIYRPLIDR IKENISSGRR FFSLEFFPPH TTEGLINLLK RVDIFANSQP
LFVDVTWVMR SDPASEKVTS SSSLADCILN FCLLDTMLHI TSVQYDEKTV LFNLERAKKI
GIRNILALRG DISDDAHVTT TDFQYACQLV RFIRSHYGDY FTICVADAGA DFIITQLFFN
EMHYFKFVSD CRKIGIVVPI IPGILPILSY QSIMKIVQLS KIVIPDSVLT TLESIKENAE
AVRNFGISFA VQLCRKSILE QLGFWKKAPV RMFPWKKHTV HSLRCREAVR PIYWTGRPKS
YLCRTRDWKQ FPHSRWGDVG NPTFGDLKHY LFSCIDQMDD SCALDMWDKE LSTLEHVRDI
FCNFIARTPN RHGHSVRRLP WNENHLDPAA DILKNELIYY NSNGILTINC QAAVNGLPSS
DPIFGWGEAN GYIYQKVDAR CILISLGYLE FFASSTCTTI LLNHVQNFPS INYHAINFDG
SFETFNYDED ATVALTWGVF VGQEIVQPTD EAFDLWQRWA GLYESGSIGR KLLQKIHDDY
RLITLIDNDY PQPCIFSLVL PN
//
