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Database: UniProt
Entry: A0A0V0RT51_9BILA
LinkDB: A0A0V0RT51_9BILA
Original site: A0A0V0RT51_9BILA 
ID   A0A0V0RT51_9BILA        Unreviewed;      2080 AA.
AC   A0A0V0RT51;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   31-JUL-2019, entry version 22.
DE   SubName: Full=Endoribonuclease Dicer {ECO:0000313|EMBL:KRX17662.1};
GN   Name=DICER1 {ECO:0000313|EMBL:KRX17662.1};
GN   ORFNames=T07_6453 {ECO:0000313|EMBL:KRX17662.1};
OS   Trichinella nelsoni.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX17662.1, ECO:0000313|Proteomes:UP000054630};
RN   [1] {ECO:0000313|EMBL:KRX17662.1, ECO:0000313|Proteomes:UP000054630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS37 {ECO:0000313|EMBL:KRX17662.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX17662.1}.
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DR   EMBL; JYDL01000084; KRX17662.1; -; Genomic_DNA.
DR   Proteomes; UP000054630; Unassembled WGS sequence.
DR   GO; GO:0005840; C:ribosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   Gene3D; 3.30.160.380; -; 1.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR000554; Ribosomal_S7e.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   Pfam; PF01251; Ribosomal_S7e; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054630};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN      398    580       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      753    928       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   DOMAIN      989   1085       Dicer dsRNA-binding fold.
FT                                {ECO:0000259|PROSITE:PS51327}.
FT   DOMAIN     1261   1366       PAZ. {ECO:0000259|PROSITE:PS50821}.
FT   DOMAIN     1589   1750       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1804   1972       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     2007   2073       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   REGION       87    108       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED       63     83       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2080 AA;  237154 MW;  8D58CEBBF50AE81E CRC64;
     MGMAASSTNG DAMEDESEME AFDVVRIADD VIQRLRFGSQ DIFKSEDPVI DDMLIESAYR
     IQYETLRQDL IATQEEVARL KRQLQERDYA ERKKHHSESH KSRKTFKRGE AEQLKLEQKL
     KSTVQDVKTK FMQYSCHQLC MDKEMEVMKC FDLNRQKTLK CSKLVSEFIN CINSETQQRI
     GRMVVVLLYH LHGKLLLILE FMFTNSAAFC KNNIDMVYGT LNNLVRASKD SVTDLERQVS
     QVLYDLKHSQ DLQYYVKEDL TFVSAKEIDV GNRAVIIVFV PFPQYKQYRR ILVRLIHEVE
     KKFGGKHVVF VAKRRILPKP TRGKRKITQK QKRPRSRTLA AVHDEYLNDI VFPAEIVGKR
     IRVRLDGSRL LKVHLDRNQK AAVEHKQNGE RTKRSKELLE CAKKENVIVT LGTGTGKTFI
     AVMLIREMSE SVHQPLKEGG KRSFFIVDKV PLVKQQAEHI RINTNLKVGE FHGALGVDFW
     SAKIWMEFFD KFHVLVMTAE IFRNILAHGF IKFDIVNLIV FDECHHATKQ HPYKKIMELY
     KLCYNNNNSG IQPRILGLTA SVMNKKGDEI GLQKAIRNLE TTLCSRVVGT SHAELLKFYS
     ADPHIAIVAC KNDNKYDWHE LDLFFQHLVR STQKSLERCG RDCEGNESLY IQHVCDVLAK
     LDSIMGQLGP WCALQVCKQM LQSTTKLATR ISTLLADDED NNLFSLLTSG SDASRSVWLE
     VLKTCLKVTS VKLKRHIGLV DSVQKLKCVV SDRLSALLNI LDSENGSSFV NNLLTSSNKP
     FGIVFVNQRL VAYCIAILID TAKKLQPRSY SYLEVDYVVG SRMSAEVVEP SYARQEEVLK
     NFRHGKLNLL VATSILEEGI DVRHCNYVIR FDTPLTFRSF VQSKGRARQK IAYYTILVQD
     RFLESFQEML NSFVETEKFL KVNGRDLNIL TRTKDRDHSY SGNNDQVDNC RKEVNLPNGD
     VDSLVEPYYT YFEENGTVKK AACLVLSSAH NVIKRYCNKL RKDRFSDSSP KFSVQTILNK
     DLSISYVATV QLPTTSPLKK KIEGKPMQNA KLAEMAAAFE TAKMLHAMSE LNEFLIPPVT
     VRKEIELKED EEFFSISSRS YYLKEVPDVL YKAIPRADQK SYLYAISISS IESFLPRLGI
     LVSKPIGNLP RFSVFTDESY IDVEIEFVEE TSYSAHQLDI LTSFHCCLFK NYLFSEETDF
     IFDPENAACS YLIVPLKCEY NSKCSVDLST AEKIINWSKD VSHIPQQRSE KFIMNSSSYF
     NAVVYPWYKN KDDRDFYYFV TAVDNTCTPM SPFPFKMYRS FAEYFEVAKQ VKVLDKNQPL
     LSVKMVSFKR LNLLCEKQIS ILLFDFDDDT NSSHCKVVPE LVVIHPMPAS MWRCLIFLPT
     VLYRMNHLLI AEQLRLQILR EAMFPGEVLE GNCEIQPLNK DWYLLASRLN DMCIVDNQLP
     VKLSKLQVNS NSAAAATATG SIDPETQALL EEFDVRFCNA CPTVPVDDQL DILTGNSVAE
     SHKAESNDEC LFDTQFSLQL LSSIQPQQQP LENVDFGIVE SDGESDFVAA PALPESELNL
     FVEPSDVSDT ATAPAQHCPG PQCRDVLRAL TLRSAQDMFD LESMEALGDS FLKFIVSLHV
     FKKETSWNEG RLTSLRSEIV SNTNLFNLGK KKLLQAKLTA VPFDPTAQWL PPCFRSLAAL
     ESGYESVKEL IDEGASKKKK QALKAKTLAP VVVAECYEMC SLNRTHQMIY DKSIADCVEA
     LVGCYLLEAG MRPAIKLLKW FGIDIDDNLM NLLSSSSSSV FCSENCVLIG PEAKIHSIWT
     AYDLNSFEAK LGYRFTNKAY LIQALTHSSY NEVETPVTDS YERLEFLGDA ILDYLISRHL
     YSSKRIRSPG LLSDLRSALV NNVFFASMAV LNHFQKYFLY FNAELLTVNE RFVLAMRGLK
     ESVNFHNELY MMEEEQDDDE KETSKFAEHV EVPKPLGDIF ESVAGAIFLD SHCSLATVWQ
     VYYNMLAEEI GKQPSDFTSF NKCLCHPPIS PVRHLLELEP ERVQFNILDR EEGNSGVHVQ
     VVVTGKGRFI GSGKSYRTAK HAAAKKALRE LHPTSNHFII
//
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