ID A0A0V0RUP5_9BILA Unreviewed; 3905 AA.
AC A0A0V0RUP5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Cubilin {ECO:0000313|EMBL:KRX17978.1};
GN Name=CUBN {ECO:0000313|EMBL:KRX17978.1};
GN ORFNames=T07_10559 {ECO:0000313|EMBL:KRX17978.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX17978.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX17978.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX17978.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX17978.1}.
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DR EMBL; JYDL01000079; KRX17978.1; -; Genomic_DNA.
DR STRING; 6336.A0A0V0RUP5; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 23.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 26.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF37; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 25.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF07645; EGF_CA; 2.
DR SMART; SM00042; CUB; 25.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 26.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01180; CUB; 26.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 165..201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 300..339
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 384..428
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 431..468
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 469..506
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 512..634
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 638..758
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 764..918
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 919..1035
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1039..1154
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1160..1276
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1280..1395
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1396..1523
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1525..1659
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1663..1790
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1791..1904
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1908..2018
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2181..2302
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2303..2418
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2422..2546
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2548..2665
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2669..2786
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2791..2908
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2910..3025
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3029..3148
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3149..3262
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3264..3384
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3391..3527
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3553..3665
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3668..3781
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3785..3899
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 191..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 458..467
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 496..505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 764..791
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 1396..1423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 1525..1552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 3905 AA; 439263 MW; F7184684215FAFFC CRC64;
MQLLAKQFNI YFGLLAMFQF LFFLLLFETV LKVSSSDVFS PYESRARILI HDGNIFFHPG
ENKNISFVTN HHGSITFGDV DINSVATLNV VNALKHRLLY LETRQNISVE QLHGMAQSQS
RLQVSLQTIQ AQIESFTSPK DYSQPMQKKL RKLIRNFNAV RKSLSKNECD SSPCQNGAMC
IDAYERFYCI CSMEFTGPTC AEDIDECTLY KDTDLGCQNG GTCLNTHGGY RILNTDVNVL
QTGMDTDAQN HTIVVKQQVQ MLYVDHMEFV CRWLIRTLVN CICEPGWKSS DSITNPYCID
VDECLSNPCF HGVTCINLPG SFKCGSCPTG YTGNGLQCWD INECIENNGG CSTNPKVQCI
NTYGSFYCGS CPAGYEGDGY SCSKLSMCER NPCHASATCI NMPESPKGFR CQCPSGTVGD
GIGLLGCQLS QEDPCTPNPC LNGGICQAYS SSRFICHCKP EYVGNRCDEF TSCHSSPCQN
GGTCVSNPQG GYTCHCKPGM NGKFCEHEAD TCDKFYEQNT GTIQHPLESD TYNSLQTCSW
TITVEEGKVI NATFPLFDLE KPVRATSNTC PFDNVTLYDG ADDSTPKIGS YCGNKGDLIA
PEEYIITSTN KLHVVFQSDR TFSGAGFKLH WDAIIPSCGG RIYKTSGHLK SPNYPGGYPS
NSHCRWTLIT QPGFHYKVKV SNLIFNLEDS DCAADFLEIR DGSRIDDPIL ARHCTTINKP
MDSVYTSMPY VTVYFRSSEN RKQITQSDGK FLIEYNVQEV DSHCGGVIKD MHGTVESPNY
KNGFYFHDIT CIWVFDSSNL SPSKVKLTFV EFDVRGTYMA PSWWRYRHSS PFWTRRRVGS
AVTGLIHHGP YCQGDFIEVI IIFYHIRDGG DENADLLSYY CGDFEPGVVE SSGPKLYLKF
KTNNKNNGRG FKLTYDMVCG MDIKDSNGTI QSPNYPDPSL QPMTCEYKIT VPPTSAIELT
FIESNLGNGY ELTSQACTEN YIELQSGIAD VWFNRKFCNA PLWPPFITAG SHLKIKFVTN
GSTKNRGFQA QYRTYEIGCG GVYNSKHGVI TSPNYPDRYI QNLHCIWKIA VPRGLKVKIT
FTTFALEESP NCLYDYVEIY ETYRSKNEST GFIGKYCGHL NPPPLISPSN EMTVLLHTDA
NINSGGFELR FDGINTTTNC DFTFTESSGV ITNTGYPLHV TQPMTCEYHI RIQKGYRIRL
FNFNYSLPCN RGYLEFRNGP LITSPPFPGI PKSQICDDVE IDTFKSFGNM IVVLFKSLTS
SLYYRPLWFY FQYEELAESC GGTISDISGS IASPNYPLKS SHAYDCLYHI VVSEGNRIAL
FLLSFEGSVH PNSACTTYDV LEITDGRFHS SPIIEKVCHS DTTTRVFTST SHEMSLRYMH
YLSSTSGFLV TYNTVCENIK LFGIHGRIKS PGFKSRISKA RHCEWIIETY PGNMLRLHFF
YFSIQDESSN SLHECTKSSL KIISAEGNVI LSKRAANVTL KDPAFCDISE QPTFLFVESN
MVKIEFTAPQ NSLDHFGLEW GTDGCGMKVT ENNGKLIITN NTGNPASELK VCAWTFHAPL
GQKIELQINY LGILRSQILD CSYPVRYGDL FDLDAFHVFN GLNNASGLSF KTICDHINRN
NPLIIDSVSN ELFVLFVYHH YSSVPEHDGT ILHVEYKFKD GGCGGVHTEL QGSLQTPGYP
GRYQREIECN WKIQVPHGYL VKIEIKDLNI GNYFTKCRWS VTNEGYLAIY DGPEANTSYP
MLGMFCSNVV PENSTVITTG NEAFVRFVGT KNNANSHKDA RGFLAKYEAV CGSKLRASST
RQSFGSLKHL ESQECEWLIE TAEVGQKITL NVDYLSRSMS CELNYIEIFD GPEPKNETLL
SQLCDASKSL SFKSSGNYLY LKLHSHLTIS PTTAMRFSFS YYLSDSQCGG DYYSLSGRFS
SPLYPDLYPS NVDCVWRIFN SLGSRVRLTF LSFKLAESEY CEKDFVEVRE KDQGGRLLGR
FCGEQFPPSI VGWESVWIRF RSLSDSSEEG FQLHYELLMG GDLEGKEGRL TSPFYNYNSL
WNSGDYMQPE IININETEIY DQDKEYIWWR ISTEVNLVVE ATLSNVILEN YWWLHGLNML
NEGEYLQIYD GFCDLTVISK PEDCTLIQSI EYATPKVSVM SKTNHLSVLL HLKIGGTPKF
ELSWNSAIAN LQEDELENSN CRYHLTATKE RKNITSPGFP LEYSPATECT WWINHPKNHS
VIIEIIMLDI EAHPKCSYDA LEIFQAPSMW YEDFQQTYQM KYCGHHAPNG TETYSHESEV
LVHFHSDHSF AGKGFVMEYW LGCGSVFSLT DSAQILTSPN FPEFYENNQR CNWLVVAKTG
RAIKLHIDIL QLEDSANCTK DYLQIYNGPE NDSPLLGHYC GSSLSGEPLT STSNILRVLF
VSDELVNAGG FQLTVEEMKL DCSSDSLVLV DDDSVGELYS PGYPHIYRHS MDCLWTIQSP
SGTRIQFDFD PDSFDIEQAP ISSEVGCIYD YVEILDGATI AANSLGRFCG NRVPETIQSS
SNYMTVRFLS DESAAKGGFK ATYRIARCGG TVVGRQGVIT SPNYPHHYEH LKECEWYVRV
PEGGYVNFTF ADLNFGGVGR RNASECTADF IEIRESNKTG PLIGRYCSGA DKNKHGRTKS
NLMYIMFKSD ASLNGRGFKL LYNYTSYECG GHLNQPNGQL MTPHYPDFLS GSLFCEWIIE
VPLSRRVTLT FEDFSLPAGL MHFCFNAHVT LYSDPEAMNP IVDAAMCGAD YELPMSFRST
GNVMVVRIET ETASDARGFR ATYHSDEPAE CGGVINSPTR IDYFPKENST IPNGIYCRWH
IKNPNKKDST IVLKIHHLNI RSQDTCYFDY LAIQGVSIAL GVEDERKKLC GELRDVTLTY
YYREIDLYFV SRWYSYYMTN FTMDISFSKC GGILTATEGI ITSPGYPRIY NYDSHCEWLI
VAPQGFEIKI EFKDIQLEHH QFCQYDNVTV HNGRFTSSPI VRTYCDAYDT IPDNYFVSSS
RFLLVVFQSD NVNSNRGFKL EYKTTSPGCG NVIHGAEGYI VSPNFPKNYG SNLYCRWEII
VPNAFHVKLH FVIFDVSPSE NCTKDFLVIE ETQNRTASIF DHSWSVSRRL CGYAVEGPFV
GKNDRVRITF QSDASIESTG FNISWTSDCG GVYKDPKGII SSPYYPNDYG NNMHCEYIID
PIHSNEYYVY LEFTHFQLEE TGYVDNCLDY VEVTSLTEGN VLLNTCGQVI PERVNGVGPL
KVIFHSDSLV TNVGFSAQYG STGCGGTFNL SSDEFFSRMF GIGSIPFPPY HNQMNCTWLI
SAPEGHVIVF KLSQLSIEET DYCEYDFLQV HDGLTTADRS LGKYCGSTLP DRAAKSTSNH
MLVRFITDAS LTEPTAFEGT VTATPGPEMG CGGSINVTTA GTIRSPTQEN SALYPAYLDC
HWILLAPIGR VISVQIVEFS LEASNLPMCF DYLEVKNDAQ APFLPPNNRF FPVQIQDGHY
DSGSLIGKYC GTMQPWRFTT STDKLQLHFV TDDQIESTGF VLKYELKPGN NNLHDLHLKN
ERQFVFETRE ALCGAALTPL KRRQFVHHTQ SASNHRCRWG IESAGDGKKL LVQIVHLNVE
PAEDDCSTSY IEISETPKDK NARKFRDCGT SSGFKIYSKK AILITSALST LPMSRISFNI
SYQMIDECNE TIAVAVDQQD GELTSPNYPN SYPHGAHCTT TLIAAPNYKI RLYFNAFRFE
PERGQCKNDI LTISQPNSKA LQYCDTNIPP TLTSKTNQLT LHFNTDNSVA YQGYSITYLV
TDQDCGGTIQ LASGSITSPN YPGDYPPRVR CRWLISVPRG SWISFHVAHL KMDPACDDQS
DRLELRPANG DNQKPQIYCG EQQPSTGAIM MSNQVEVLFT SGDSKANSYE GFRLKFHTID
RAEMH
//
