ID A0A0V0RX20_9BILA Unreviewed; 1015 AA.
AC A0A0V0RX20;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
DE Flags: Fragment;
GN Name=Synj1 {ECO:0000313|EMBL:KRX18996.1};
GN ORFNames=T07_10414 {ECO:0000313|EMBL:KRX18996.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX18996.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX18996.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX18996.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178,
CC ChEBI:CHEBI:58456; EC=3.1.3.36;
CC Evidence={ECO:0000256|ARBA:ARBA00001786};
CC -!- SIMILARITY: Belongs to the synaptojanin family.
CC {ECO:0000256|ARBA:ARBA00008943}.
CC -!- SIMILARITY: In the central section; belongs to the inositol 1,4,5-
CC trisphosphate 5-phosphatase family. {ECO:0000256|ARBA:ARBA00009678}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX18996.1}.
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DR EMBL; JYDL01000065; KRX18996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0RX20; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR002013; SAC_dom.
DR InterPro; IPR015047; SYNJ1/2_RRM.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF257; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR Pfam; PF08952; DUF1866; 1.
DR Pfam; PF02383; Syja_N; 1.
DR SMART; SM01165; DUF1866; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50275; SAC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054630}.
FT DOMAIN 140..466
FT /note="SAC"
FT /evidence="ECO:0000259|PROSITE:PS50275"
FT REGION 981..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX18996.1"
FT NON_TER 1015
FT /evidence="ECO:0000313|EMBL:KRX18996.1"
SQ SEQUENCE 1015 AA; 114038 MW; 032CD95F1A408926 CRC64;
LYSCGYLENY DAKVMPFGRT YSVYLNAAGK ENIILLENTR NKNCVLGFAN GVVLSLDQKK
WLILKSDCNK ICDVHACLGV LSLPVVETEG SFVQYLIVVK NASLIGQLFN CEAYRITDVN
CLPLWGDFNQ KPSDPRIIQI QKLLSCGLFL FGWSNAQNAF VDISLAMQRQ FLNNKKGDTR
FHWNVTLRSH LQQFGIDAED WVTPCICGVI EVKTAYVGHQ QAKACIISRI SSERMGTRFN
VRGVNDFGNV ANFIETEQVI FYNDNVVSHV QVRGSVPLFW DQPGIQVGSH KIKINRSLEA
SLVAYEKHFQ QMKICYGSAA IINLLGTKND ENTLSESYQT IHSDSAFDSI IPFISFDLHS
EAKGSSRSEC LKKLWPKLET LVNTHGFFHC SGSELLRKQT GVLRVNCLDC LDRTNSVQSL
IGLKILQQQL AALGLSDKAN ICTRFVELFK ACWTLNGDHC SKLYTGTAAQ EGKSKFKDAS
ISVTRTIQGN LMDKSKQQAM NFLLRNSKLG TDTVAQINCI VPNRNFHVYP SIGISLIEKV
EEFVDPLQLR LFCGTWNVNG GQLTSSVVFR NETSLADWLI NLMPNFNGDA SHRKPYDIYA
IGLQEMVDLN ASNVLNASVS YQNSWRDAFL KELNSISQYV LLETIQLVGI CLFVFVQPEL
LVHIRDVSTA AVKTGFGGTI GNKGGTAISF TLGASSLCFI CSHFTAGHSQ VQERNDDYEG
TCRRLRFPSG LNLFSHDFIF WFGDFNYRID MSGEEVKHLV DLRDFDSLRE ADQLVQQKMA
GCVFIEFEEG LINFAPTYKY DAFSDNYDTS EKARVPAWTD RIFFRKRRPY FKAQDTCQLL
VYCRAELKTS DHRPVGAVFN LHIGHTNVDK LRNAVEDIVS SMGPRDATVM VSVQSQRDMV
PFVDSVLEKI RHLGIKALLT KCIGEHLFCT FGKSEDAIAA LSMDGVKIGQ NVLCVRLKTT
DWETDCQNVV NQLFNDDFDK NSKNSSLNDR RNNEAAMSNS TAPVPQRPPP PKRYS
//
