ID A0A0V0S0H4_9BILA Unreviewed; 2547 AA.
AC A0A0V0S0H4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=General transcription factor IIH subunit 4 {ECO:0000256|RuleBase:RU364024};
GN Name=pxf-1 {ECO:0000313|EMBL:KRX20269.1};
GN ORFNames=T07_3783 {ECO:0000313|EMBL:KRX20269.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX20269.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX20269.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX20269.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the general transcription and DNA repair factor
CC IIH (TFIIH) core complex which is involved in general and
CC transcription-coupled nucleotide excision repair (NER) of damaged DNA.
CC {ECO:0000256|RuleBase:RU364024}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364024}.
CC -!- SIMILARITY: Belongs to the TFB2 family. {ECO:0000256|ARBA:ARBA00007132,
CC ECO:0000256|RuleBase:RU364024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX20269.1}.
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DR EMBL; JYDL01000051; KRX20269.1; -; Genomic_DNA.
DR STRING; 6336.A0A0V0S0H4; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:InterPro.
DR GO; GO:0001671; F:ATPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.2610; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR040662; Tfb2_C.
DR InterPro; IPR004598; TFIIH_p52/Tfb2.
DR NCBIfam; TIGR00625; tfb2; 1.
DR PANTHER; PTHR13152:SF0; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4; 1.
DR PANTHER; PTHR13152; TFIIH, POLYPEPTIDE 4; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF03849; Tfb2; 1.
DR Pfam; PF18307; Tfb2_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU364024};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU364024};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364024};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364024};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364024}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 633..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 683..729
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1018..1083
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1148..1267
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1268..1339
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1600..1711
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1736..1965
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 874..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1486..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2049..2071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2231..2274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..973
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1494..1529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2547 AA; 282246 MW; 222485A7573A9DEA CRC64;
MRRIVQQYKR TATNFIVLTT VRNDYKGRIG PILQKYIPKG KMNSTHKVPQ TFLNYLSQLP
SGILNKLYES AVACTGIYRY LPSVAQQIVM RLSLVSSGTT IADIEGWMVD EKKDILHESL
KYLRQLHILQ ECNLSSIESV VLNRVFAKNL RLALLCNDAI CFKTVAVDPK HQKSFADLDS
YASERWESVL KYLALPSAQS EKSVSVETKR VLQDSGLIQL CDSKMQLTSD GFQFILYDRR
QQLWTYLLHY LAQLEKKGSP VHDCIMLILQ ACLGSHRAAY STENLTEAAL NFIQHLREIG
LVHQRKRSAG WFYYTPLISV LTGLKSSSSS SKEGFLIVET NFRVYCYTDS VLDLAIVSTF
CEPLFPNLVA CILNRESVRR AFQVNISAEQ IIQYLFSNAH KNMQKQTPTI PSTVTDQIKL
WEMERDRFKF DPGVMYSNFV SDTDYITIRD YAKDLGVLLC EHEANRALVV SADGHEQSNQ
FLTLFTSDSK KHTINLVSFS EVKNDQLKQH GEKSTHYSSV SLRFFISSLS VACKSSSYQR
IRKLSDNCSD RSNSVSVVNT TSQSIACWLI DASDFLQRMA DTAVIEALRK PSKFRNLKLV
CSVGYGERGW GRVAANWSNK FCPLFAPMLS VKLVVLFLSY LLLLLLFLSM MIMVGTFVCP
DTWGGEKKNE VQLVYFFLRR LDVFRGVDDQ TLKTICQSAR YEQYQQAGKF LYKKGQRSFC
WYILLSGAVF CDGRMYLPVE SFGKRVRFSE HYRISGCILL ESSEMIVIDY NSTEPSVGSY
PESREQLPMA ATSLVVNRVP VADGEPTTSS TSSCSTSPSM CSSKVVHCRP IHQTTASTSF
AASFKKACTV GEQQSSSCSV DEVEINTAAE IPSNLLPNRR LSSSQQQQQQ QHRHGGTLAM
IRRSNSIRSS GSSSAGGRVS GFKPIAAIPS TSSTTMSDDD FSGLPEISVD SDDSDEAELE
EEDEEEEEEE EEGCCLYAES SFTGHLRDLV RECLEKLPTE RTDDDIAILL DFVQHMSSFA
SLPIYVKCEL CRKMVFAVVD KAGTIVMKHG EQIDSWSVVV NGEAEVVFPD GHRYEYHIGD
CFGVQPTEQV QFHQGEMRTL VDDCQFVLVA QADYVQIISK LSDSYTRQLD SAGQVVCEKE
KRAFESRVGY VLTKAKPCKL ISALFEDRRD CVVDPHFVED FLLTYRTFVD NPAEVLEKIL
ACFSEPSKRE KVARLVLLWV NNHFGDFESN AEMTNLLEKF DKMLEDEAMF NHQQLLNIAC
SVKSRTRNVT YTRSNRDEVL HFSILGGTEK NNGIYVVKVA AGSAAERVGL KRGDQIIEVN
GHNFRNIARH RALEVLRGST HLSMVVKSNL LGFKEMLVAD QCDAGALLAP VLLQQAVATS
KDGSSRRRMS PVQPRRSLVQ LHQLGGVDGL PMPSLRPPPR QHKHSLHLET QRAVMPALVH
SLANTNINTT TTTSSRTLAR LNHAGKESGG SGSRLGKLIK KLRQGSSSSA LSLDADDDND
HVDGHEPRVD DGGRKCSKQK TRQTLDDCDA TDEAVRRATL GRPTGAQSVS MPSGVPLLGR
RLKHSRSNPD LSSTANQPIL PGGFGQMISQ YYEPVRPQHP EHILKVYRID QTFKYLSVYK
ETSAQNVVQL ALQEFGMCNN SGVGNDAVHS SSSSSSTSTI TTTANGGEWS LCEVTVTADG
LIKQRRLPAQ MQNLAERISL NSRYYLKNNN CPLPLVPDEL APDLLKDAQA QLGCLHASIV
AAQLTLQDFA TFASIEPAEY VANLFKLGVA PTRWPRLADF EQSVNRETFW VATEVCKERN
SIRRAKIVKK FIKIANHCRD FKNFNSMFAI ISGLEKPCVR RLHNTWDKIS SKYTKMLDNL
QSLLDPSRNM SKYRQHLAEA SNDPPVIPLL PVLKKDLTFL HECNPTWCDG GMVNFEKLRM
VAKEIRFVTK LASAPYELSS MFERSGNQAQ LNDALLHMNT FEGGSSVATM KKQHVQHRVP
LSRKKLYEQA LMVRRVKFYL TQFEPISDES VLDKLSLELE PVTVTSGGGG GGAHSTSTGN
LGVVTVASAG KRSQPSPSLS SGSSMSVTSS DCSRRCNGPK FGVESPHAVQ KMLSLVDHSR
VRASSNNTRA IGIGSPPTSP GAPLKAARPA TAAVAHSLLY FGSNIHQHQQ QHHGRFNNHD
LNTFAIPPPL SSVVPVDLTC ESSAVTSSIT PSRLHGSASA TSSTDSVISS HQSDLLPLSS
SSSSYIPHAV SCDSTDSGHG SLDSPSMITG VGVASSSSSS SPPSQRQSYP PRPNTITLKA
ASNSTTHYDL YSTTTTGVVV STKPFRSFEK AQQQQQQQQP QQNFRFTAPQ HENRASSSVA
SSTFLKQSQP LSATLTIGSR RLATTADQSQ SDTNNGATQV SRAYVRMNVV VTFGECSSCS
SSFEKFMYIC IFQAKCSTWK SFFLENKTQN KKKLCHTEKS ELVKHQTFFV STVVINQREP
SVSLVIGTTS APEVTSIFPE SGSIENGPRQ YFSSVAFVHE VNVPCSAGVT GLVLKTVDIV
VVCFAEGLPS TKSVNGATLK ASGKCFR
//
