ID A0A0V0S0S2_9BILA Unreviewed; 995 AA.
AC A0A0V0S0S2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 03-MAY-2023, entry version 30.
DE SubName: Full=Protein vav-1 {ECO:0000313|EMBL:KRX20274.1};
GN Name=Vav2 {ECO:0000313|EMBL:KRX20274.1};
GN ORFNames=T07_11679 {ECO:0000313|EMBL:KRX20274.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX20274.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX20274.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX20274.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX20274.1}.
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DR EMBL; JYDL01000050; KRX20274.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0S0S2; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20810; C1_VAV; 1.
DR CDD; cd21201; CH_VAV; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd09940; SH2_Vav_family; 1.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035031; Vav_SH2_invertebrate.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 5..124
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 203..402
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 435..567
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 578..627
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 662..730
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 828..925
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 928..993
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 746..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 111894 MW; B0679682DD18F79C CRC64;
MEEETELWRQ CAAWFSRCGV LDENRRALYP KATLLDFAQA LRDGVLLCQL VNRLHKDSID
MNVVNLRPQL SQFLCSKNIW LFLNACQNVF GLNSEDICES ADIYKAANFG KVLQTLSKLS
NSPLALRSGI RGFPEVVEDE KELADEYYNN EVYRQLAKAA DSKELDEEIY DQASDDERDQ
IYDHIITRAS LQKEDDEFIP NDQRGYCIKE LVDTERKYVN SLHMIIQKFY LPLKEVLSFE
EHNRIFMNLP VLLPIHSAFL SEIQTALRTS QDTGGGGGGG LSTTSNVVTG GPLLGDVFVK
YKRQLTCYSF YCSSLTRAQR TIDQLCSEKS DFRQKVLECQ IEANANKFRL QDVLVVPMQR
VLKYHLLLKE LLKHTPIDHE ERFSLQLGWD AMRDLSLYLN EVTRDCETRQ IIQDIQASIV
DISLHDNTEL CDYGRLLKDG EIKIASPLDD RKLKNRYIFV FDKLLLICKH HKFCCGRLTR
NNEHFREAST ATRAGFCWKI MKFKMCPIGT APPPPEFANC FRLQLKDCLG GVQMQPPDAD
CRPYYLMHAQ SEESKNSWLL TLRTAHENVK PPAACLTKHV LMYTSFDQAT ECSSCEKLLR
GLFFQGYKCA HCGVKLHKEC ISSLPECGRA RECLARSSTM LDSRKAFAGQ SFSFSPSGGR
RICSEKFVAI APFTGSDCNA PSLTFRENDV IQLLSMDVGF EGQWLGRLIQ GDNVGQVGFF
RPEYVRRQVA SSSMVKRPSW QAATALSNSN NSNHGSGAGA GGGSGSGTGG SGGGGGSGAG
AGAGICNHHS TVLPPSSTSL GRLASTVRPV SLSTFGYVNL EELTHYPWYV GEMDRLRAEQ
LIMGLPLGTF LVRFSRARSQ YAISISYSGK EHFDVKHVKV ELDKHGFYLD AGRYFPSLVE
LVNHYEENNL NQSFQALDTT LKIPVKALIV GFATALHSFE ATSPNMVSFQ RNDMVIILSK
KDSERGWWKG MVVKGTERRV GYFPCSYVLE KEDFD
//
