ID A0A0V0S0U7_9BILA Unreviewed; 2699 AA.
AC A0A0V0S0U7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 33.
DE RecName: Full=Trehalase {ECO:0000256|ARBA:ARBA00019905, ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|ARBA:ARBA00012757, ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN ORFNames=T07_3637 {ECO:0000313|EMBL:KRX20348.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX20348.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX20348.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX20348.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|RuleBase:RU361180};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797}.
CC -!- SIMILARITY: Belongs to the NIP3 family.
CC {ECO:0000256|ARBA:ARBA00007710}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX20348.1}.
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DR EMBL; JYDL01000050; KRX20348.1; -; Genomic_DNA.
DR STRING; 6336.A0A0V0S0U7; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005740; C:mitochondrial envelope; IEA:InterPro.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProt.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0019222; P:regulation of metabolic process; IEA:UniProt.
DR GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.20.25.10; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR010548; BNIP3.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR001529; DNA-dir_RNA_pol_M/15kDasu.
DR InterPro; IPR001661; Glyco_hydro_37.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR PANTHER; PTHR23403:SF12; TREHALASE; 1.
DR Pfam; PF06553; BNIP3; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF01204; Trehalase; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SMART; SM00661; RPOL9; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|RuleBase:RU361180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT TRANSMEM 2658..2685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 125..160
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1011..1059
FT /note="DNA-directed RNA polymerase M/15kDa subunit"
FT /evidence="ECO:0000259|SMART:SM00661"
FT REGION 459..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1692..1737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2212..2249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2393..2448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2484..2506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1696..1713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2233..2249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2699 AA; 308128 MW; 501A8987767233CE CRC64;
MMFYPKEDVR FVAVRKPSDK SILRRLSSAY YYHEPHSIYR CRFNPSIDLW NYLGFCDEAG
FFYLYDTMFF EQKNDPKLLF KLQLHRNAVC DFAWHPCGRG EVLTGSADER IILTDCNIAK
AVQCFHGHSY SIRSLSWCAE NTNLFASGGR DGSLRIWDVR LRAGCISTIA KAHYFGDFLT
ASSSTLCNQK RTKTNLRKIL MSDVRRSGTS LNVPVTGVHF HNQHYVLSGA YTNTGIRIWD
LRKLLQANKA VAAVDIWPYP SPRNSNYSRY GYTTFCVDSS RSLLFVPCTD NTVYQYSLSS
FNPKPIARHT GVSINTYYVQ CAVCPYAPYL LCGSSNNKAM IWNINESGDP QFSLNDFEGR
DANSVTWNHY GQLVTCCDPP SWRIWTVYSE KQQQQLDMER RNLVLRIQEN QRLESLQSER
VQQQQQPLEE PIWFASQARS PPSRMQALAP VQSSPMRRYL HQRNKRPASS SPLSTAALDV
NQPGPSRPVS SSRAPTTTPA RKRVRTTNTY YEIKKHFKFA ASASTLNLGL HGLHDGISDS
LVKNGKNAAA QLFCLFPLEL FRSVMGDKPV TPPGSFFRVY SQDRQYRDLA MTGDKASKLA
CGPTKRAFDH DVVWATDHPA AGPLLDELVD AMVYAKCDVN VPDDANMSVM MTLRSVNMEK
PQIKQDAASG MRSSALDPER MKSVLQAMQK SGAQGVSQDN IDRALQLIEL ALKEKRAISI
HEMEEVLRLV EFNVFIGADG LKQMFERLVN DKTLTEGQAN GILQPLLAKA ASKADGKLPM
QEVHYFFYHL ACAGMVHEHA NSISIKRTCN HLNFCTDLHY LFKVMRRSGA QRSRKENIDR
ALRMIDLVVK EKREISIQEM EEILCIVESN VFIGIDGLKR MFEHLVNKKT LTDAEAIGIL
PSLLAKAAAK AQKKIPLQNV REALKNFMTV IFTTLVHPAL ERCMSTATNL HYLFKITVQI
SNHSVIIRPQ CGCILSNNST NLSDLLYYFN ARSLCKKLKK CQIKLLSIAP NNILYPKEDK
SRRCLLYACR NCSYVTDDIV SVCVYTNKLR REIDELAQVN VDVIYDPTLP KTDDHSCPLC
NNSEAVFFQS QNTKAEPNNK VSLDKMMYYV VSLLSQIYCQ GPILDAVQTA HLFPDSKYFV
DMALKKDPIT TLQNFISLGD RVKDKAVLRA FVDEHFDPPG TELETCFPED WKPSPKSFNV
IKDYEFRRWA VALNRIWKEL CRRVKSKVFE HQELYSLLYV PNPFIIPGGR FREFYYWDTF
WIAKGLIASE MFTTLKGMIR NLGYMVENHG FVPNGGRVYY LFRSQPPLLI PMVYDYYLAT
GDIDFLQEML PLLEQEYSFW LLHRGMTFGD DSNNYMKLFQ YKAEMKMPRP ESYREDLELV
QNLTDDHARE FVWAQIVSGA ETGWDFSSRW FSHTGPEAFT LRSIRTWSII PVDLNAFMCM
NTKLLANLYE MAGNVTKVLL YQARFEQAKA AMKQIHWNEQ DGIWYDYDLE TKRHVDVYYI
SNVLPLYAKC YDDEDVPSRV YNYLKTVGAL NSTRGVPTSF IQSDQQWDSA NAWPPMVHML
LEGLRTSGDP EIIEVAKDLA IQWLRSSYDA FLKTNSMFEK YNVSSTAGEM PFGSGGEYEV
QTGFGWTNGV ILDLLVKYGD VITAQDATTG TINYWKYATY VVFVMKSELK QDEHALKEEI
LGFMNKIGLN RDGKNKNSSR ISKPVRRETK PDDSAWNNNS SGSKNKQHQQ QQQSGNKLLP
TKIKTEDLNE HPVSESSVQR WYDAKFTDVV GSQPLSEHSL MKMGTYAKQL FQNQAVNYEK
ETMNKKNNSN QLRWMNSVAS GGTLSDRVAA LGMLVQQSPL HNLKHLDTLL NKVTKKNRHE
ALIAADVAKD LFIEELLPDR KLIPFKSRPY VEIENTKGQS KATVDRKLLL WQFESELKMK
YQQFLHALEQ LCHDTVEAVR LKGCILLVDL LIAKAEQEQF ILSSLVNKLG DQSVKVATQV
VKLIGRLFVA HPNMKVVVVD ELEKLIYRKN ITPCAQFYAI CALLKVPLNR NNDEDLACKI
LNVYFDLFKI VIQSDVENQR LLRHLLLGTN VAFSYSKGKF DRISEEVDTL YKIAATSSLY
INLQALALLF QVLDVKAEIS DRFYRSLYRT MLVPELLSSS RCHAMFFHLL FKSMSQDFSD
QRIRAFVKRL LQVCLMAPAP FICAALLVIS QALHGRLKRF IAITDQWVED DHEEQEKVDD
EEEKEIENGK KKQTSTESNN TNDNKQNANN IYGNVYGSRE YNIAGREPLH ANADRESLVE
LLLLRNHYHP TVAVFAENLL KGNHINYSGN PLDDFSLMHF LDRFVFKNPK KSISENVEEK
NTEKRGYKRK IYDPWSLRSL PVTSSAYALH HKSHVPPDEK YLHSFMTNEN VKRAEEQLSE
ESDDESVNSE DEIGNKRRRR RRRRSKHSED SDDSDNPSDS SGDESDFEAG RSKLNTAALT
SDNDDSTDGG VLDDDDATTA AEEFGEILEN DDEEDEKKKH DRKRKAYKKF QKMSSPRGTI
VVNEMDVADA DSWVELSHDS ECGSSITFLT DPSGAHGSPH KYTPPGGQTS PVLQFDGDLE
RVKFQLCRQF SNIQGGKSAW LSDWSSRPEV VPPLQYRRSG TIVRTPPNSP FGSSEEETSD
QSKPWFSLRH SRFVRHDWFS LEVLSVYILG NVLSFLFGVC IGLAICRKGR SCCGTHFLP
//
