ID A0A0V0S134_9BILA Unreviewed; 2686 AA.
AC A0A0V0S134;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 33.
DE RecName: Full=Trehalase {ECO:0000256|ARBA:ARBA00019905, ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|ARBA:ARBA00012757, ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN ORFNames=T07_3637 {ECO:0000313|EMBL:KRX20351.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX20351.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX20351.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX20351.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|RuleBase:RU361180};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797}.
CC -!- SIMILARITY: Belongs to the NIP3 family.
CC {ECO:0000256|ARBA:ARBA00007710}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX20351.1}.
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DR EMBL; JYDL01000050; KRX20351.1; -; Genomic_DNA.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005740; C:mitochondrial envelope; IEA:InterPro.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProt.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0019222; P:regulation of metabolic process; IEA:UniProt.
DR GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.20.25.10; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR010548; BNIP3.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR001529; DNA-dir_RNA_pol_M/15kDasu.
DR InterPro; IPR001661; Glyco_hydro_37.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR PANTHER; PTHR23403:SF12; TREHALASE; 1.
DR Pfam; PF06553; BNIP3; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF01204; Trehalase; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SMART; SM00661; RPOL9; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|RuleBase:RU361180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT TRANSMEM 2645..2672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 125..160
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 998..1046
FT /note="DNA-directed RNA polymerase M/15kDa subunit"
FT /evidence="ECO:0000259|SMART:SM00661"
FT REGION 462..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1679..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2199..2236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2380..2435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2471..2493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1683..1700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2220..2236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2686 AA; 306624 MW; 0A5917291FE937B7 CRC64;
MMFYPKEDVR FVAVRKPSDK SILRRLSSAY YYHEPHSIYR CRFNPSIDLW NYLGFCDEAG
FFYLYDTMFF EQKNDPKLLF KLQLHRNAVC DFAWHPCGRG EVLTGSADER IILTDCNIAK
AVQCFHGHSY SIRSLSWCAE NTNLFASGGR DGSLRIWDVR LRAGCISTIA KAHYFGDFLT
ASSSTLCNQK RTNLRKILMS DVRRSGTSLN VPVTGVHFHN QHYVLSGAYT NTGIRIWDLR
KLLQANKAVA AVDIWPYPSP RNSNYSRYGY TTFCVDSSRS LLFVPCTDNT VYQYSLSSFN
PKPSNRLYVA RHTGVSINTY YVQCAVCPYA PYLLCGSSNN KAMIWNINES GDPQFSLNDF
EGRDANSVTW NHYGQLVTCC DPPSWRIWTV YSEKQQQQLD MERRNLVLRI QENQRLESLQ
SERVQQQQQP LEEPIWFASQ ARSPPSRMQA LAPVQSSPMR RYLHQRNKRP ASSSPLSTAA
LDVNQPGPSR PVSSSRAPTT TPARKRVRTT NTYYEIKKHF KFAASASTLN LGLHGLHDGI
SDSLVKNGKN AAAQLFCLFP LELFRSVMGD KPVTPPGSFF RVYSQDRQYR DLAMTGDKAS
KLACGPTKRA FDHDVVWATD HPAAGPLLDE LVDAMVYAKC DVNVPDDANM SVMMTLRSVN
MEKPQIKQDA ASGMRSSALD PERMKSVLQA MQKSGAQGVS QDNIDRALQL IELALKEKRA
ISIHEMEEVL RLVEFNVFIG ADGLKQMFER LVNDKTLTEG QANGILQPLL AKAASKADGK
LPMQEIIFFT TLPALEWCMS TPTDLHYLFK VMRRSGAQRS RKENIDRALR MIDLVVKEKR
EISIQEMEEI LCIVESNVFI GIDGLKRMFE HLVNKKTLTD AEAIGILPSL LAKAAAKAQK
KIPLQNVREA LKNFMTVIFT TLVHPALERC MSTATNLHYL FKITVQISNH SVIIRPQCGC
ILSNNSTNLS DLLYYFNARS LCKKLKKCQI KLLSIAPNNI LYPKEDKSRR CLLYACRNCS
YVTDDIVSVC VYTNKLRREI DELAQVNVDV IYDPTLPKTD DHSCPLCNNS EAVFFQSQNT
KAEPNNKVSL DKMMYYVVSL LSQIYCQGPI LDAVQTAHLF PDSKYFVDMA LKKDPITTLQ
NFISLGDRVK DKAVLRAFVD EHFDPPGTEL ETCFPEDWKP SPKSFNVIKD YEFRRWAVAL
NRIWKELCRR VKSKVFEHQE LYSLLYVPNP FIIPGGRFRE FYYWDTFWIA KGLIASEMFT
TLKGMIRNLG YMVENHGFVP NGGRVYYLFR SQPPLLIPMV YDYYLATGDI DFLQEMLPLL
EQEYSFWLLH RGMTFGDDSN NYMKLFQYKA EMKMPRPESY REDLELVQNL TDDHAREFVW
AQIVSGAETG WDFSSRWFSH TGPEAFTLRS IRTWSIIPVD LNAFMCMNTK LLANLYEMAG
NVTKVLLYQA RFEQAKAAMK QIHWNEQDGI WYDYDLETKR HVDVYYISNV LPLYAKCYDD
EDVPSRVYNY LKTVGALNST RGVPTSFIQS DQQWDSANAW PPMVHMLLEG LRTSGDPEII
EVAKDLAIQW LRSSYDAFLK TNSMFEKYNV SSTAGEMPFG SGGEYEVQTG FGWTNGVILD
LLVKYGDVIT AQDATTGTIN YWKYATYVVF VMKSELKQDE HALKEEILGF MNKIGLNRDG
KNKNSSRISK PVRRETKPDD SAWNNNSSGS KNKQHQQQQQ SGNKLLPTKI KTEDLNEHPV
SESSVQRWYD AKFTDVVGSQ PLSEHSLMKM GTYAKQLFQN QAVNYEKETM NKKNNSNQLR
WMNSVASGGT LSDRVAALGM LVQQSPLHNL KHLDTLLNKV TKKNRHEALI AADVAKDLFI
EELLPDRKLI PFKSRPYVEI ENTKGQSKAT VDRKLLLWQF ESELKMKYQQ FLHALEQLCH
DTVEAVRLKG CILLVDLLIA KAEQEQFILS SLVNKLGDQS VKVATQVVKL IGRLFVAHPN
MKVVVVDELE KLIYRKNITP CAQFYAICAL LKVPLNRNND EDLACKILNV YFDLFKIVIQ
SDVENQRLLR HLLLGTNVAF SYSKGKFDRI SEEVDTLYKI AATSSLYINL QALALLFQVL
DVKAEISDRF YRSLYRTMLV PELLSSSRCH AMFFHLLFKS MSQDFSDQRI RAFVKRLLQV
CLMAPAPFIC AALLVISQAL HGRLKRFIAI TDQWVEDDHE EQEKVDDEEE KEIENGKKKQ
TSTESNNTND NKQNANNIYG NVYGSREYNI AGREPLHANA DRESLVELLL LRNHYHPTVA
VFAENLLKGN HINYSGNPLD DFSLMHFLDR FVFKNPKKSI SENVEEKNTE KRGYKRKIYD
PWSLRSLPVT SSAYALHHKS HVPPDEKYLH SFMTNENVKR AEEQLSEESD DESVNSEDEI
GNKRRRRRRR RSKHSEDSDD SDNPSDSSGD ESDFEAGRSK LNTAALTSDN DDSTDGGVLD
DDDATTAAEE FGEILENDDE EDEKKKHDRK RKAYKKFQKM SSPRGTIVVN EMDVADADSW
VELSHDSECG SSITFLTDPS GAHGSPHKYT PPGGQTSPVL QFDGDLERVK FQLCRQFSNI
QGGKSAWLSD WSSRPEVVPP LQYRRSGTIV RTPPNSPFGS SEEETSDQSK PWFSLRHSRF
VRHDWFSLEV LSVYILGNVL SFLFGVCIGL AICRKGRSCC GTHFLP
//