ID A0A0V0S5C5_9BILA Unreviewed; 1160 AA.
AC A0A0V0S5C5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|EMBL:KRX21965.1};
GN Name=C3G {ECO:0000313|EMBL:KRX21965.1};
GN ORFNames=T07_12460 {ECO:0000313|EMBL:KRX21965.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX21965.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX21965.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX21965.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX21965.1}.
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DR EMBL; JYDL01000035; KRX21965.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0S5C5; -.
DR STRING; 6336.A0A0V0S5C5; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630}.
FT DOMAIN 753..877
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 909..1120
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 258..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1160 AA; 130855 MW; 84B9F8623CBBFC61 CRC64;
MVSGGTAGTS FMQTVKRAMR LNSTEANRPA NMANSGLRHA HSEKSLRNRI KIGGETVKQM
AAALMMQRQR SHSGSATATV QRSFQTGQKQ ANQVTLNSLE RDLKICLRFL QDAVLKRNLS
LLAGSTSAVL DVMLKLMVEP RICATDVQML YEKIYHQLGE LFQQIDRILI ANEINDNDHT
AVVGLTEHLM DTVELLHQPS RLRSGVDCAD CGAALKQEPM LHTEDRNSCD SSLTDSLDLS
TDVPSAMNQI VQEDLLLNGE AKDLVPPPRR SRQARRQETI NPPPPKPPYS SALANASAAR
QTRQPRHLHP TNPTVRLKPA SGDSGIFSFC NGSDTSLPET SDLSQSVYCN QSGAENDDAD
SFDAIIRNLQ SLNASLLPCS SACEPLVVQK ETRCDDECDG DEVVTETRVG DTIVKTTKIR
KKKVWKSTIV KHCETVLPLN SETFNASSSI LENFISNPAL DSTRNVRLTE SQIVRTGDGD
QQHFEPRAKL ASFPVDLDAL LQDEQSETRC QLIGDTVKHR SVQSFKMNTS KKAIFQKTLI
NGNVTEELSA ERYSTQLQAS SLNETYCNDQ LQNSSGKAFA TENTSLSVSG KGSSFAEVSF
RNANKSSTAT NDGCNQRKRS AVSSYMQIFG NSQPSSAADF RSSALVSYER MRDRWHVNVS
KSKQATIEFG LTTNANEDHF AHFDQANSSY ENWLDIFEND QNVDYKKLCA FLFAKKQPKQ
LQIENANRKA IADVKYLYEL DVRDHLFMKD GDDDCNIRGG LVDVLVAHAA SACHSQNGFL
YREAFLTTYR SYILPFDLLK KLVERYNHLS TQRASDEQSK SAKSCFSLIV RVVDELSHVE
ATSELLKFLV QFIHRLIVDG ELLLARLLRQ KFVEKYDEKL LAQQPNSCRP LFCRDPDQAT
KSHSIFDFKA SLLAEQITYL DWFYFQKIDA NQAEEKCPRL TEFTSHFNKM SYWVRSRILL
LADQRQREHC FVKFLKIMRH LRRLGNLNSC LALLSALDSG ALRRLDWPRS AVDQLNQYSS
LIDSSQSFKV YRTALAETKP PCLPYLGLIL QDLTFVQVGN ADYLPVEEVG VANVVNFAKR
WQQFMILDNK NDNVLVFFNN FDDYANEEQI WAISERLKPR NMSANTFYID CVYFKLIGFK
RIKSAEKVVI HVNLKTKKNY
//
