ID A0A0V0S719_9BILA Unreviewed; 1651 AA.
AC A0A0V0S719;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0000313|EMBL:KRX22181.1};
DE Flags: Fragment;
GN Name=scube2 {ECO:0000313|EMBL:KRX22181.1};
GN ORFNames=T07_1746 {ECO:0000313|EMBL:KRX22181.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX22181.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX22181.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX22181.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX22181.1}.
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DR EMBL; JYDL01000033; KRX22181.1; -; Genomic_DNA.
DR STRING; 6336.A0A0V0S719; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24046:SF5; EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SMART; SM00214; VWC; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 997..1108
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1446..1504
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1505..1566
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1567..1606
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1607..1648
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT COILED 1417..1444
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX22181.1"
SQ SEQUENCE 1651 AA; 186128 MW; CB62DBA8FAB32780 CRC64;
LKSDLLPLLK FVDHCILEHW CETTTSMAFV WLLSFFATLI IVNNDKPPKM LMHSNEKVVV
NLKTGNVSGT GRFVRVEESF EYSKSNAGSD WSLTGNCNRR AVLRINLHSS ISLVKIVGFY
NRPQLWTLHI SQSKKQSGGC GYLWTNDLAQ SEMCIQNRRI TFYCNNKHSN HSNCRLFENF
LPSRRRPVVK LEITEKRSKF YINDAKRKRF LPIAEMVSLF PKNSQNRTLY LGLNRLISEP
GQYGTGLCKV IISLLKSREK RDECTFENRT CDGEKGECQF ASGRYFCVCK PGFQKHGNRC
RDVNECEHMN GHCVQICANT IGSFKCSCYV GFQLADDQKN CLDIDECKTD NGYCEHYCIN
TIGSYYCSCE RGFVLAADGF SCILKKPSQI CDQLGCTHGC VKEFGSCYCK SGYHLHSDGR
TCISTCSIGN GGCQHNCLDT RKGTICMCHS GYFLASDEHS CVASCEIDNG GCEKRCESTE
NGIECYCDNG FILNADNKTY IDECQNWNGH CEQICINIPG AYECACENGY LLSNDRLSCK
DIDECQSSDV CDHICINQPG NVDECSIGNA GCQQICHNTP GSYYCSCHTG FVLHSNKKDC
IAVDYCLKSS DETSIISSSL NCRGNMCTLV CHKNAEFVAK KMKSSIKIAC SKNISAVTSI
KAAGSQWHYM DVSFLVDRCI LLNRLFRMKT NQKNFEAEKG ILLIENSGKI DRHQQCGMNP
EFASIEITCL KRAAEMQQAN NNRSLSVFSA QGWYRIADAI TSQHFINLFS EIARISGLKL
RYRSSEMMLR TISKSSLHLL CNQKHPKKEC RTLSKDSVMK TFKNMMPVTC EPGNFYNITV
GLCFPCPTGT YQPMSNALSC IKCPSVDYKK NQSAGRDAIE NCATPCLPGH YSSTGMEPCL
PCPYGFYQSE SGRLACTACG EKLTTYDFGS TSFSNCSVPE LCLPGFYFNV DENKCQSCPI
GSYQFEYGKN YCIRCPQNLT TEFPASKSQN SCISKRCVKQ MGYLTGFIAS PNYPGNYPNN
ASCEWFIRAP LGKRILLFIV QLHLAADHCG DYLVIRKNRS PLSPMTLEAC SSKAAPFALL
GQSRRLWIYF RSDSNNSHTG FKIHYVFYSD EHHSLVEDFV RDARLQAMAS REAFFKSDHY
LQLFMNVIAE PENYPAYMQL AIQDISQPVT LTKSETAEVA SLLMTKKFSI LLQFVQIEHT
RGTLFYVSTG NVKVFELYSS GLKGELTVYW RRQYRIANLH VKYEFDDENM HTIIFELVNE
DLRLMIDCIE AVVGDYPEID FRILQSNKTT SAHVGHRGRG NSKFAGEIRR FVITNESLAG
KLCSIRTQDY DQWKSAAFEK RITETPMQDP ILPHEALLQA ENICKKLQSR VEILEAIALD
LKPEKGAKLK LVNLPEPSEV KIDGQCPNCW EYLRFKINYL EEEFKRLRKN MKDMDERLKS
VLLRQRGCVI NDTEVDDGYR WLDQQSCTEC TCHLGKVFCH ALGCPKLKCD HLIKRPGQCC
PECGQDCHYM GANYKHGDAF SPKQCVQCRC DNGDMSCTYT TNSCPKLSCS IEDQITPEGH
CCAICKNADF CAAAPCHPDA DCINEEHGHK CVCKKGYFGD GTNHCFDINE CQPDDGKSYP
CSSGSRCINT AGSFHCNCLP GYRQQILQAI T
//
