ID   A0A0V0SAK8_9BILA        Unreviewed;       693 AA.
AC   A0A0V0SAK8;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Degenerin mec-4 {ECO:0000313|EMBL:KRX23736.1};
DE   Flags: Fragment;
GN   Name=mec-4 {ECO:0000313|EMBL:KRX23736.1};
GN   ORFNames=T07_3089 {ECO:0000313|EMBL:KRX23736.1};
OS   Trichinella nelsoni.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX23736.1, ECO:0000313|Proteomes:UP000054630};
RN   [1] {ECO:0000313|EMBL:KRX23736.1, ECO:0000313|Proteomes:UP000054630}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS37 {ECO:0000313|EMBL:KRX23736.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX23736.1}.
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DR   EMBL; JYDL01000022; KRX23736.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0SAK8; -.
DR   Proteomes; UP000054630; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF248; DEGENERIN-LIKE PROTEIN UNC-105; 1.
DR   Pfam; PF00858; ASC; 2.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        45..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        594..616
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          235..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          647..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         693
FT                   /evidence="ECO:0000313|EMBL:KRX23736.1"
SQ   SEQUENCE   693 AA;  79117 MW;  773C1DADD983CB46 CRC64;
     MSNRVTFQRD TTTKRRFKNL LLNFSDKTTA HGVPRIGMAT TKREGAFWTF VCVTSLTVFL
     FQLSLLIARF LRFETTTQVE FDAFDNKPLS TPKTSTLLAR KRRASSADEK QYRYTPLYAR
     CSCPNEESDC VPFTSAPLED GEEICICYFD HVTKSPWPCY SEKQWRSEWC SRCSPNGNCL
     QILKKRQLSL YEDVKQCVCH SNGKTCLVAD KNKPERIWDP AYRDVRLDRY TTSTTTTTTT
     TTTTTTTTTT TTTTTTSTAT TTTTPIPTTP SEVQEYVDAL GFEGITDETA KVSRAQENTL
     FIMAELPPET KKKVSHQKKD FLLQCSFNGR QCDIENDFEL LMDPVYGNCY MFNSNSTINR
     TTSRAGPIYG LSLVIYVDAD DYLPTTKASG VRLLVHSQEE YPFPDTNGYN APTGLLSSFG
     IRMKKIERLP QPYGDCIKEG KTKDYIYKDQ IYSLEGCYRS CFQMEMIKSC GCGDPRFPVP
     EGRRHCRVKE RKARECLENV IQKSGGLHGS FSGKCDCRQP CVQYVYDMSF SAAKWPTPSI
     ELDDCNDTAE ECIRKLKKNA LSLEIYFEQL NYEVLKELQA YQWVNLMADF GGQLGLWMGV
     SVITIIEVLV LIYEVIKICC TRRKKPTMNK HHRRSIYDDS TVEMTIKIHP PNQNNPKDSI
     ATAHSENDDE CSQNSYAMEN HLHRHNAEIP TQF
//