ID A0A0V0SDG5_9BILA Unreviewed; 1221 AA.
AC A0A0V0SDG5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=FERM domain-containing protein 4A {ECO:0000313|EMBL:KRX24799.1};
GN Name=Frmd4a {ECO:0000313|EMBL:KRX24799.1};
GN ORFNames=T07_1355 {ECO:0000313|EMBL:KRX24799.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX24799.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX24799.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX24799.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX24799.1}.
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DR EMBL; JYDL01000015; KRX24799.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0SDG5; -.
DR STRING; 6336.A0A0V0SDG5; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17103; FERM_F1_FRMD4; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079:SF2; FERM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1188..1210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..355
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1041..1155
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
FT REGION 840..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 534..561
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 840..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1221 AA; 137033 MW; BA34182FFA6244DD CRC64;
MTSMKKMTEG RRTQVVLLDD RRLEIVVQTR LTVAELMNIV ASHCHLKDPD RQYFGLAFQD
DKQQLFWLHD DRRVLDHEFP KKLAPSSAVL TLHHLVKFYV DSFMRFANAA SVELLFLQVR
NQIYRNVINA DHDTIFQLGA LLVQAYYGDF RNENATRNAI KKLPVFPESV LRYYYSPLEC
EDQVIEIHKN LTGMSRGSAV VKYLTLVERL ETYGMHFYEV KDKVGSPFVL GFSSRGIFQF
NSNDKSSALR SFGWNQLENL YYRDKKFSVE VHDPRRVVHV LSSFNPLEDA FQSSTVPGDN
LIAAIGDPTT QVSLSRRTFV PSNVHVLVYL CESPQLCKNI WSLAISQHQF YLDNKAISRK
DKNVQIRHIN ELLDNLNKLP FSAIRMHTDT SNNSTSDLGS SVSSQSLRSL PNMCYADEEQ
ARDSEFYKQL QSRKQALELL LIEKLKELKD VCIQEGNITG EIPSELYSAL APGEAEPKIK
RRVGTSFSIS PDLVNKLVTI DHISKLEADV EIKRKIVAGH EKLVNDPSVS SVVRRRRRQD
LKQAMQQLKQ LESQLEQLCL TATKYNMHCI NYSHSPYKSD KTNSVIRGQP SPFACNSLGR
LQSCRNAASG VASSSRLSPL RGRDALPYYA QAPSTSASNS RLRSASIPNS PNLGLRCAED
SVPCSSGLLE LNMRQSSSSS SAVGYRPFVS YQSKYRQQNY PTLLDRPNVG VGCSRSLSSQ
SLQNDERDVL SPLRFFPKVD AVDHALGSYN VPQQRTSWDQ DCLERMNHAV LGSSESVNSG
LTHRSISSST GAKAAIPGCN GQFPGMVNYV GSLDRRQLKN RGTGATGLLK RLSEKYTVIG
RQQQQQQQQQ QQQQQYQESY ASMDHSPPRY PSRGSSAMVV CQPALEAIRP YSNDDYLKYT
NRQPAVAPAR RVQHEVNLPP TFSSPQHSAM VHQRTGPKAM IAHDVQDVLS WYDESKPLGV
ARTNASCSDV CISASAGTVT NAKAANKSNG ASSTGSPLKA ATVETFNGEM GCAECICVFF
LCLTVFTEIK ALRFLVRPGR PVCVKEEAAK GVVVTGDYSF TEGPAQLSNI IVTDFQNHIL
FKRQDFTDLT GKFAFTTDKS DLFEICVSTK SQHTGAQGGM LREVELNIRH GLEAKDYEQI
AKAEHLLPVE MELRRLEDLG ESLLQDFAAV NLYEEDIRNT NESTNSRVLY LTLFSVSCLL
LLASWQVLYL RRFFRAKKLI D
//
