ID A0A0V0SME9_9BILA Unreviewed; 794 AA.
AC A0A0V0SME9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN Name=tag-165 {ECO:0000313|EMBL:KRX27913.1};
GN ORFNames=T07_13739 {ECO:0000313|EMBL:KRX27913.1};
OS Trichinella nelsoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6336 {ECO:0000313|EMBL:KRX27913.1, ECO:0000313|Proteomes:UP000054630};
RN [1] {ECO:0000313|EMBL:KRX27913.1, ECO:0000313|Proteomes:UP000054630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS37 {ECO:0000313|EMBL:KRX27913.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX27913.1}.
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DR EMBL; JYDL01000002; KRX27913.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0SME9; -.
DR STRING; 6336.A0A0V0SME9; -.
DR Proteomes; UP000054630; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054630}.
FT DOMAIN 76..220
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 389..633
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 794 AA; 90715 MW; 728D3EF74F393C54 CRC64;
MPEPVSQSTA GDVCGLKRGL PVFARSAGHV QKFSLHFALE LQAICENLTV VSDNIDIDID
IYTCIYLYTK FMLNNFLIAY GSQTGQAKAI ALRLSEKCQA HNLTHRIHCL SANEKEFCIE
KERLVIFVVS TTGDGEPPDS AHRFFTCLKR QVRQKQKSLS NLKFALLGLG DSNYNTFCGA
PKALEKLLFQ LHAKAFYPTG YCDEAVETAT VAEPWICGLL ELLLSNNNLD SIDKTLPLAK
LSLEMENTEI ASLGSTPERL NGIMTPRSNG RESQAIRCHM ETDPNYRYDY YYDDDQRRRG
DQSTVDPTIA HSPSMPSRRP RFYTFEECQC RWAEPSVVGC EQLRNVIELK VPSMALIVPK
LTSIVTHEDY TQLNFPTTTP ETEYAGQASP RYMAKLLKRT VLTAPTAKKT KVLLEFDLSG
FDTPYKPGDA FSFICSNPQN EVNWLLYRMN LSVLADKRCT LKLLPEAERR GDKLPPYLPE
VSSLRYLFTH CLDIRQSPSR ILLRLFAEHC KTFGEKRRLM ELCSSQGQQQ YQRYIRRAGL
SLMDVLHAFP SCLPPVDRLI ELLPRLRPRP YSLACSPLVE EKRCNIVYSL VSVTAEEGRF
YARNGLATGY FETMQIGDQI EMFLRQSSNF CLPSDILNTP IVMIGPGTGV APFISFLQHI
KALSTEENRW CERWLFYGCQ FESLDYIFRK QLEDFHDSFL LTHLVVSFSK EEREDKAKYI
QDSIRDNGFS LVRLLTEMNQ SRVYVCGDVE NMAKEVFQAF IDILQSHGEM SADDAKKFMS
DLITNERYIL DYWL
//
