ID A0A0V0T8D4_9BILA Unreviewed; 2267 AA.
AC A0A0V0T8D4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Protein HIRA {ECO:0000313|EMBL:KRX35311.1};
GN Name=hira {ECO:0000313|EMBL:KRX35311.1};
GN ORFNames=T05_10560 {ECO:0000313|EMBL:KRX35311.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX35311.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX35311.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX35311.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX35311.1}.
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DR EMBL; JYDJ01000452; KRX35311.1; -; Genomic_DNA.
DR STRING; 144512.A0A0V0T8D4; -.
DR UniPathway; UPA00886; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.520; Ubiquitin activating enzymes (Uba3). Chain: B, domain 2; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.10.290.20; Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR040676; DUF5641.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR023318; Ub_act_enz_dom_a_sf.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF18701; DUF5641; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF00899; ThiF; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 188..370
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REPEAT 1120..1151
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1176..1208
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1219..1251
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1637..1663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2267 AA; 254585 MW; 9B98675D7118BA88 CRC64;
MWSRPLHWKH SITLHAGCKR DGLSRVATSF SNRRARASTA LARPPFHEAA LSTVLRRPCL
ISVTLSASCR AFMRVAGSRR RSSQWLPPLT FRPSFPLQPL SSPAPEQSER HPAILPIEHE
VTHGLIRRCH LRQLHAGMFQ TLAMLRQRYW IPQRRSRVRH VIRGCLQCRW ATSRLLQPSM
AALLEDQTNP APAPARVGMD FTIPLFVGVT KKATAPRYAC LITCMVSRAI HLELVVEMST
VGVLQTLRRF MPRRGRPATI QTDNFRSFQS AASELRRLWR EIDVDQVQRY LAGQRIQWKF
IPQRAPWMGG YWARFVRTTK ESLRNVLGQA LLDDEGLRTL LCEVEACLNA WPLTLLLTGR
TYADLPEVKD QDPIWHPPER GRREWNSRWR YRQQLLAKWW RRWRSGYLAT LLPRWKWTST
TEGPKLNDLI LILEDNVPRA RCPLGVVTEL FPGNDGVSRA ARLRTSTAEV TRLVAKLVVL
EPARISDGRT ISIGGYGDET YLTFPPFQSC QYSRYSPLRS RANMYHSFTS KKLLVVGAGG
IGCELLKTLV LSGFADIEVI DMDTIEVTNL NRQFLFRKEH VGLSKAKVAV ESVSVLNPNV
KLVYYCKPIQ SREFNVNYFK KFTAVLNCLD NIEARSYVNR MCLICHLPLI DGGSLGRKGQ
VDVIIRNITE CFDCHKHSPS HDYPSCTIRN TPTEPAHCVI WAQHLFNQLF GEVNSDQDVS
PESLVTGEEF EATPQVQPLT NIISLQDLAK NHNYDPEVII KKLFVNDIEY LRTMEKLWEG
RQPPTPLNLR WFRIGLDESL QGTEQKDWES RDQNVWTLKE CFKVAVSCLS VLKERAKNAP
LIWQKDDPVC VDFVTAFTNF RCHVFNIEKI PRFEAETIAG RVVPAIVSTN AVVAGLMVLK
LYAVLERRKD FYGSVAISSQ EGMPRVLSIA PSTEVTGCEY CVAVKEVEVS LNVSTFTVEN
LGKIAKELSV MKPEIMLEVA SPRLLFAHDY KLSAEEGKKT LSEISVKHGS LLRCEDGATF
TNIRIIISDC PEIYDSEENC RRNLFIKVIF DSIELIGNEV HKAELGLPIY SVDIEPAGNR
FATGGQSVTG IGLIVLWSLK PVIDVENETN DKIPLLLCRL EAHSTCINCI RWSSDSRYLA
SAGTDQAVKI WRFVSYIPNV QSRVTAVEHW KCVSTLHGHA GDVLHLSWSP GDRYLASCGI
DNIIIIWNAK KFPEKITSLV GHEGFVKGVC WDPIGKYLAS QSDDRSLRIW STVDWNVVHK
FRRPFKEAPC ATHTLRLDWS PDGLLLATAH AVNNGGPVSK IIERNGWKCE LDFAGHRMAI
TCVRWSNVLY HRNRKVFLTE KSNVCSCCAI GSKDRSLSVW SASENRPVVV LTDIFESSIS
DISWDSSGLI LIAASVDGSV VCLVWTTDEL GVPLSLDEKI NNLRRYYGNV DVGLLGLQRK
SDQNSNKIIE DADYVMTHAK VIANRSNENG VNGGVCASTT AVRTAPPPST SDSNWNVQLE
TRTKSGKRRI TPINVEVVAE VDTDNNSQPP WIREGVGLGV AGKAKGLIDE KMTVIDNAER
WSGLNSTTVE PLVASSFSSA SAFKSTLVKS RKGDNFDAGG KSISKSSEDH SGGIVEEFLE
KSKSELKFDK KKSWHQKGKK ALKHAPRESP ISQTFPSSET EVEVETDFQT HQTVAVSSSS
KQKTPTHRLE ALKVVQLLMS SVVVDESESE VLLQLSNNIG SKPKGKFAEL LCMKNSNCVW
KVLLETGAVA LKANRHLILV VFENGMFDIL SPLDGRMMCL TNVLGDSVHY VNLDGKLIAL
VTVCAELYVW SFVKSLELVC QISLKALLRD PKRNLSRIVF SAVGMPIISF NDGSLFSYDA
SSKIWQKLLN PSDSFIKYSP TSMLASTKAY LKTKGRFQNL CKNLFSSVTF TAERDSEMQE
RIREGFLERF SLASRAVGSE HEYMYWLSEY VKLLVKAESE VKLRCLFRTL VESDEHMKTN
SMLSRDKSEK RSAVTDLLPL VAANPKLQRL YSELSFLVAE KSSNEQADDL YSEIAATTTN
SLKLSCDVMS VEKFMKSAPE EKSSHMSMAV ILLNKMNKRC VGYVLKSDKD SSSGSRFILT
TRTCSANFNR QINAPIYILP ENKERHVKAI HTRGFHESLA VIEMQDKYAF KLASESTCPL
EFPEISEECF TVYAVESQVN KRDIVAEPYK SSPKSSCEKY WITFNEESFA CAATSQKGKR
NGLGLVCSQG GKLALVGISS ENQQTTSVTS FTLLYPYAKQ LEALIAS
//
