ID A0A0V0TD28_9BILA Unreviewed; 1175 AA.
AC A0A0V0TD28;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN Name=Npr1 {ECO:0000313|EMBL:KRX36907.1};
GN ORFNames=T05_6285 {ECO:0000313|EMBL:KRX36907.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX36907.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX36907.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX36907.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX36907.1}.
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DR EMBL; JYDJ01000337; KRX36907.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0TD28; -.
DR STRING; 144512.A0A0V0TD28; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06373; PBP1_NPR-like; 1.
DR CDD; cd14042; PK_GC-A_B; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF494; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRX36907.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 558..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 624..923
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 991..1121
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1175 AA; 133457 MW; A260479FF08A4CFB CRC64;
MRGSVKWLLL LLLLLLLSLL LLLLLLLLLW LLLLLLLVLF SESLYKRRAL DATPRATSAS
GGSMKADEGV GPVALLVRVV LCWGLLICDC SRAAPAQHRI QMMVAMPYEL GPPWQNPFLL
SRSVAEPVIQ LAIDDVSRKG FLNNIAIDLH FRNTNCSDTL GPYYAVEAYC AKQLDVVLGF
ASAYALAPVA RLSGFWSQGV PVITTIAQVD SLDDRSVYKL LTRMNGSYRE LGSTIIHLLQ
LLNYETVAFL FHSNLRRPAF GKSECFFQMV AINNQLLKAS GWRQPPVIDF DEFFDSNYED
LLKRASMSAN VILMCASVDT IENLMHAAAR LGMTESGKYI FFSIHIHSDM QDDFSWQLSN
VSQAEREQDL KTFASLKIVT LRRPPQSLYR RFEEDVKALA QKKFNYTQIT GKPYKVCKLL
YFELFIISTY GNKAQVTKFT SAFYDAIMLY AIALNETLSL GFSPRNGLEV TRRMWNRSFA
GIGGNVTISK DGDRFSDYSV LDLNPQTGTF EEVAYYAGSQ DKLYVVGQWY WAGGSPPPDR
PICGFDNSKC PSKNLSPWAV ILIVFSTLTV IFGVIALFVF RRYKLEAELR TMSWRIFWDE
LSGQKKQNKC RKRNDSRAFH WLYEQRNSLI CEENYDDSFT SLTDSLCTVE GLELEKEKNA
FTKIANYRGQ IVAVKMLNIQ RNRIELSRKL LIELKKMKDL SHEHVTRFVG ACIDSPHYCI
VTEYCPKGSL QDILENAGIK LDKMMIYSLM HDIIKGMVFI HSTDIRSHGK LKSTNCVVDS
RFVLKITDFG LNHIHELETV KEDFLSNSFW RAKLWTAPEL LRLDCPPMGG TQKGDVYSFA
IILHEMLFRR GVFYTSDENS FARDIVENVR MGMQPPFRPT VLETSFDGVI ISLMVRCWSE
NPDDRPDFRM IRKQVISLTR EFETSNIVDN LLRRMEQYAN NLESLVQERT ADYLQEKQKA
ENLLYQLLPK SVASQLIKGE PVKAEAFDCV TIYFSDIVGF TSLCADSTPM EVVNLLNDLY
TCFDSIIENY DVYKVETIGD AYMVVSGLPR KNGVAHAFEI ARMALALLSA VRCFTIVHRP
KEQLKLRIGI HSGPVCAGVV GLKMPRYCLF GDTVNTASRM ESNGLPLKIH VSSATKTLLD
SFNCFQLEYR GEVVMKGKGA QVTYWLLEPT ENHVT
//
