ID A0A0V0TGF5_9BILA Unreviewed; 1283 AA.
AC A0A0V0TGF5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KRX38030.1};
GN Name=RAPGEF4 {ECO:0000313|EMBL:KRX38030.1};
GN ORFNames=T05_7226 {ECO:0000313|EMBL:KRX38030.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX38030.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX38030.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX38030.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX38030.1}.
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DR EMBL; JYDJ01000284; KRX38030.1; -; Genomic_DNA.
DR STRING; 144512.A0A0V0TGF5; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048}.
FT DOMAIN 97..187
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 459..541
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 611..712
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 746..894
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1049..1278
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 314..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..359
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1283 AA; 144916 MW; 3958EB903624B89E CRC64;
MRNVICCKFD YFGRISVACK NLEWLFAVSG DMLKKELYMS SPKSNSRDEQ AMPPKTKNIF
KTALFAMAFK RACSKSIKKV SHADCNSVAD RIRGVAAFEH FSQQLVELLA SRGLYEELDA
GIVLFCEGKP SSNWYALLDG SVDLYCYDPE KLSELVKIKT LHSGCTFGEG ALNKQLQPCT
AIVSQRSQFI RLDFSSLSLI WEQYENELMQ NTVSLESIVK NKFVKASSSK MSKGVKQADS
VSLSAFKSET SAFAAATNYK PSKEDAVNCD PKQTAASVGE QMSLKANQPF PMSRGVVASD
SSALLSSRAK YSPLMDTTSS TSSFLSDTDQ STTDSQVSSK FSIQIKKKKK KKKKPEKRKG
LKNNFQSFHS IYCTMPADSS VDPQREVSTL RKSSSVSDKL EVKNPATSIG DPMAEPANGI
TTNATATARP DDSQVNNNLI ELKNLLTPDM QISWASRVLR SAMVVRSPNM IRDRKFQMTL
YKRCMVGTEM VDWLLRQSNS VVQNRMQAAG IWQVLLEEGI IHHVTHEYPF LDKYLFYRWV
EDERSTDAAV RALNLSDDDG IYSENDFLLA ISNLSIMGPD ALFRMVLRKA PNERSNEELE
VVFEELLNIK ALSNLSTMVK RELATVIMFE QHQNAGTVLF RQGDQGKSWY IILKGSVNVV
IHGKGVVCTL QEGDDFGKLA LVNDAPRAAT IILNENCCQF LRVDKHDFDR ILRDVEANTV
RLKEHGHDVL VLEKVPIRVN RSPIAYRYSV MAGTPEKMVE YLLETRIDCA KDEDIADTFM
EDFILTHLIF MPTNELCNAL TIYYQQGCSS INGNSALSES ILTESVEHQL SFRKRVIAFL
QAWIQISGHM FYEDPVGAAF IEVVVVEMYC AILEDSRDHP QLLPELTVVE KLMREREQAL
GSSARPPVIL SDNNFIRELP ANSPVLPFTF DKNETLLLLT HAGIVKVNSS DSLRTSTLKI
RVDQTCETIK RMASQKLGLG NGEGVELVEV KSNREKNIFT PNDTGIPTSM SHNGRLFACF
KDQVESLSPL PEQAGPSESV HSVILETLTS TELAQHLLIY HWQLFINTHE YELLYHVVGR
NLFPGKVPVN LDLLIRRFNE LQFWVITEIL LCGSVSKRAH VVKKFIKIAL HCKANQDLFS
FFAITLGLSN VAISRLSQTW EKVNAKFRKL FFEFESLLDP SRNHRAYRLL VAKMKPPTIP
FIPLLLKDLL FAHEGNKTYF DGMHMMAQTL RNHRMYKSQM LQIDSSKIPT DAQHLVRNFR
IIDDQRKFLR LSQLLEPKQK DTT
//