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Database: UniProt
Entry: A0A0V0TGF5_9BILA
LinkDB: A0A0V0TGF5_9BILA
Original site: A0A0V0TGF5_9BILA 
ID   A0A0V0TGF5_9BILA        Unreviewed;      1283 AA.
AC   A0A0V0TGF5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   22-FEB-2023, entry version 29.
DE   SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|EMBL:KRX38030.1};
GN   Name=RAPGEF4 {ECO:0000313|EMBL:KRX38030.1};
GN   ORFNames=T05_7226 {ECO:0000313|EMBL:KRX38030.1};
OS   Trichinella murrelli.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX38030.1, ECO:0000313|Proteomes:UP000055048};
RN   [1] {ECO:0000313|EMBL:KRX38030.1, ECO:0000313|Proteomes:UP000055048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS417 {ECO:0000313|EMBL:KRX38030.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX38030.1}.
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DR   EMBL; JYDJ01000284; KRX38030.1; -; Genomic_DNA.
DR   STRING; 144512.A0A0V0TGF5; -.
DR   Proteomes; UP000055048; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 2.
DR   CDD; cd04437; DEP_Epac; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.8.1240; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00027; cNMP_binding; 2.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   PRINTS; PR00103; CAMPKINASE.
DR   SMART; SM00100; cNMP; 2.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055048}.
FT   DOMAIN          97..187
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          459..541
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          611..712
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          746..894
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          1049..1278
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          314..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..359
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1283 AA;  144916 MW;  3958EB903624B89E CRC64;
     MRNVICCKFD YFGRISVACK NLEWLFAVSG DMLKKELYMS SPKSNSRDEQ AMPPKTKNIF
     KTALFAMAFK RACSKSIKKV SHADCNSVAD RIRGVAAFEH FSQQLVELLA SRGLYEELDA
     GIVLFCEGKP SSNWYALLDG SVDLYCYDPE KLSELVKIKT LHSGCTFGEG ALNKQLQPCT
     AIVSQRSQFI RLDFSSLSLI WEQYENELMQ NTVSLESIVK NKFVKASSSK MSKGVKQADS
     VSLSAFKSET SAFAAATNYK PSKEDAVNCD PKQTAASVGE QMSLKANQPF PMSRGVVASD
     SSALLSSRAK YSPLMDTTSS TSSFLSDTDQ STTDSQVSSK FSIQIKKKKK KKKKPEKRKG
     LKNNFQSFHS IYCTMPADSS VDPQREVSTL RKSSSVSDKL EVKNPATSIG DPMAEPANGI
     TTNATATARP DDSQVNNNLI ELKNLLTPDM QISWASRVLR SAMVVRSPNM IRDRKFQMTL
     YKRCMVGTEM VDWLLRQSNS VVQNRMQAAG IWQVLLEEGI IHHVTHEYPF LDKYLFYRWV
     EDERSTDAAV RALNLSDDDG IYSENDFLLA ISNLSIMGPD ALFRMVLRKA PNERSNEELE
     VVFEELLNIK ALSNLSTMVK RELATVIMFE QHQNAGTVLF RQGDQGKSWY IILKGSVNVV
     IHGKGVVCTL QEGDDFGKLA LVNDAPRAAT IILNENCCQF LRVDKHDFDR ILRDVEANTV
     RLKEHGHDVL VLEKVPIRVN RSPIAYRYSV MAGTPEKMVE YLLETRIDCA KDEDIADTFM
     EDFILTHLIF MPTNELCNAL TIYYQQGCSS INGNSALSES ILTESVEHQL SFRKRVIAFL
     QAWIQISGHM FYEDPVGAAF IEVVVVEMYC AILEDSRDHP QLLPELTVVE KLMREREQAL
     GSSARPPVIL SDNNFIRELP ANSPVLPFTF DKNETLLLLT HAGIVKVNSS DSLRTSTLKI
     RVDQTCETIK RMASQKLGLG NGEGVELVEV KSNREKNIFT PNDTGIPTSM SHNGRLFACF
     KDQVESLSPL PEQAGPSESV HSVILETLTS TELAQHLLIY HWQLFINTHE YELLYHVVGR
     NLFPGKVPVN LDLLIRRFNE LQFWVITEIL LCGSVSKRAH VVKKFIKIAL HCKANQDLFS
     FFAITLGLSN VAISRLSQTW EKVNAKFRKL FFEFESLLDP SRNHRAYRLL VAKMKPPTIP
     FIPLLLKDLL FAHEGNKTYF DGMHMMAQTL RNHRMYKSQM LQIDSSKIPT DAQHLVRNFR
     IIDDQRKFLR LSQLLEPKQK DTT
//
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