ID   A0A0V0TID9_9BILA        Unreviewed;      2930 AA.
AC   A0A0V0TID9;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Metabotropic glutamate receptor 8 {ECO:0000313|EMBL:KRX38793.1};
GN   Name=GRM2 {ECO:0000313|EMBL:KRX38793.1};
GN   ORFNames=T05_10947 {ECO:0000313|EMBL:KRX38793.1};
OS   Trichinella murrelli.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX38793.1, ECO:0000313|Proteomes:UP000055048};
RN   [1] {ECO:0000313|EMBL:KRX38793.1, ECO:0000313|Proteomes:UP000055048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS417 {ECO:0000313|EMBL:KRX38793.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX38793.1}.
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DR   EMBL; JYDJ01000254; KRX38793.1; -; Genomic_DNA.
DR   STRING; 144512.A0A0V0TID9; -.
DR   Proteomes; UP000055048; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   Gene3D; 3.40.50.2300; -; 10.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24060:SF172; CELF35-1; 1.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 3.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 4.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KRX38793.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..2930
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5006869219"
FT   TRANSMEM        2610..2635
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2647..2667
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2673..2694
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2715..2735
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2768..2786
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2798..2817
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2829..2847
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2639..2814
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   COILED          1561..1588
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2930 AA;  331788 MW;  B01721156338E198 CRC64;
     MVNVNCSLIV LFFTYGAVFG GNIALEQCAS DQLPAEKSAA AIITLILDVR RTLNNHDGPS
     CGTVSEEGLQ IEEIAQWVIK ILNQASGTVF GLPVTDSFIP GIELGLQVLD TCGIASRAIR
     LSAEAFSDLQ SPKHKCTFND TRISLGVIVK ADDSTMHHLA DFFHQYKKSV IGLGSRSNML
     KQKQIFAVQP DIDTIVQTIL KTAETMEWKH LWLIYENTDY GNEGKTLLTN MSAQQQSICI
     LGTEQFSHGT NSNGNIKLIL KKILSKKEDS YLIILFMSRP VALQFLQAAF EEDLIADSRR
     MKWIMSDGFD GSFVDIFDLS KGVIAISDEN PYRVPEFLSH WTEADPKEHS KFWYKEFYQH
     RHKCRLEDDT NPAFYRFGIC KNKKSAINHT DSELFLTPSA VHVVDAIFTY AIALKGAWMA
     KCRGRPGLCP QLVQMDNQDF IRFIKHVEFS YQKENRSPPS FISRQVSHRK PKSQVAVFQV
     QSDEQANLLL KQIFRYDRFR NNRLLQLSAP LYYDNFGKID MEKKHSMTTN DKSRRCMTFQ
     KRKACHIIPG DLYMIAIIGM QEKGSYFDYC GQVNVEDSLA DIVFFNHALS SLNKKLLPDL
     KIGSIVVDSC SNAIFAAQQI GTCLTNMEEI IFSKTENDAS ISKHPLFIGA LIQADGLESA
     EISHLLSLTL PSLPIVMYGK NVVPGIAPNI INFGTNFQNI ADGVFNVIQQ FPCHYKQFIV
     SRKYAPSVSV IESMAMNNSI GNFKTLLTNF GSNFDGISAM NWIERNANLS VVVLFLEEAE
     LLEFLKTANQ SATSSNHIYL IILDHNWTFE KLRNFSHLEG NMIIFLHTDN DANYSLQDHI
     IHEAVDGIFN SKNIWIREYI ENNLNCGKQN EKNEHNAIVA SCKDETLLYL KKLALRHSIK
     TNRLLASVDM LVATLHHVVK NNCFDGFATG SNCSQFLQSF LNLKENRMLN YVTKHYEKIS
     ENDMFVLPAK IGIYFQSQLN NEKFQQIGTF YFNSNKFEIM DLSLFKNLSN QASSYCLNGS
     SENQYIEQST VRKSEELLTT VLPVTGISDY LLQSENIKEM HVFFESTVMN IPPLSTGESV
     LIGVLLPLTG SANCGHVDYN KVKNEDAVYA LEALLWARKK IHILYNMDIQ FIIFNTCSSV
     LKTNILLNSF LINPRQFFGE KFGLNYTEDL VVGFINGYSA GPASVASEIL SEASIINADI
     RNNVQNQNSM TLHFSDNLNS YISAALQFLE QFQITFISIL YSNDEIAVTF TDKFRLKANN
     YNVCMAYISQ VDSTQSLNTH IDNLEGVRNA GATVVLVVLE FQKLLAFERA LEKQSHGLTF
     FIISFRNEIN AWNSNHFPVL LNSSILLKRQ ADLPKDFMNH LLQLRYDNND GNYLWSDFVK
     KKFNCTTECN DRLPDVSDYA MLNADQVLSA VNALSALVAG VRKLGSTICK NQTIICKELK
     ELPNFGSELL HILQKEPFPA VDDISRKIRI DETRQMNEKL TISTTLILGS NEAPLLQPIA
     VYENEKLTLN RIGTEIKNQP VFTSQCLDIH QCKQCWKSMD KLLNSYLRKF SPALEVHTGS
     SDDVEEVLSI SEEEAENVEK KTNKQIEESK SFVCIKSTSN IYLMAVIPIH NREQKKLTCG
     AFSSNQYQRW KAIQWSLERL NYYLLAQNGI NLGIIAVDSC SDQAHTIKQL SYLINGDMQL
     NSCIRGNFSD QVIAAILVPY NQEDASHEAT VDLLTSNGIL TFNWDSSFAY SANSMLFSTG
     LIEQSMVNGL VKFLAKTKWH YVAYIYSNNK NSLRRRHIFS SLANDNGICS EYILYPSHNK
     QSCGEMTELF DQLKKIKLNG LRGVVLGLSM NKLRCFLDRM ERLVASGQFS TNQFTFITAL
     DANYKQAFFR YESVAAGFVV VHPTAVELDE FHQYWKALKH LNVSNDIWWK ELLATDDWPE
     RQDEKLLYLA NAAYSAGHAV YETKQQLCGS GMVASKKCNN LIMHHSFRNA FRENVATSKF
     VDESGQMFTF GKDGLATQRV SISLLVLDLD IVQWIEIGRI ENDVFDTKQR GNSPFQNYEP
     MLYLQKLTSK CTNATLCPQC SRCPSPVQLS TCPSVHCKNE FEKSTTPAQS DVTTEKVNLP
     APNLHYSESK LHWIVPSPNG IYAIALVPVH FPSEELFSCG PLDIFGGFRQ ASAFMHSVEN
     LNKQLPKHDQ IGLIIIDTCN AKSDLAFSWI YHLSTNNRSV QILAVLDAGY SNSNELAELM
     KNFQIPLFTI DPKLEMSKNE WNLQFKFDLN WYAEIACSVI HRLKFITPLV LFEQSNKLHS
     SIMEKFIYCL ESNNFNNVIT KIPVNNYREL NAILNGLSNR PTAVFVLFMS STFISAFRRA
     VVQQPYNIGQ TIVLGYGLER IFTTASPIEQ VEQQHSNLVT WLSIELLIEN EADTSEFLLS
     KQLNNYQPIP QYWFEEYWQQ MFTCKLSNSE IVGNFHFHKN CTENEQINST ALSKNLESDM
     SVWFLMNVVV DGYKKYVDND CAQVSTAAQP TRLVNCLKNG NRSNLLKYLK SSRWNQIVVG
     NEFSNYKTLE NCKIVLKKIY MDKNQLLAES VALWKQTFTL TINGKPTSSS ASFSSSKDII
     CKTSSVEEDC WKRFDFAVSN LEETNRMNEI WIVIAISLAG LGMTVCIITS IVLVVTDHAA
     NDMFNHLTLF GLFNLYAVTL AFTWQLSDIV CTIRLYATGF AWTLVFAPLS VKVVQMRLFP
     ENGKKQAYCW KKRNCIMVIL AVVFVHGIGV LQWMIVSKST KIPVLFKQAK CAPVGSLATF
     ELSLTFSMAY PILIILATMI TAMTTTTTNM SKYNKSSCGI AVTCMLTIII WLFWNITSTM
     EIFQLSDPVI AMGILINASV LFVGLRLRDN KNTSKQSRRS YNVNMIRNEA SLQPDPALVP
     YGVNFSKSKL GTFDSDQSYS TYSTVPKTKR YFNVMTYDGS SEFSATTMVN
//