ID A0A0V0TIF8_9BILA Unreviewed; 1603 AA.
AC A0A0V0TIF8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 2 {ECO:0000313|EMBL:KRX38809.1};
DE Flags: Fragment;
GN Name=scube2 {ECO:0000313|EMBL:KRX38809.1};
GN ORFNames=T05_10778 {ECO:0000313|EMBL:KRX38809.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX38809.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX38809.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX38809.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX38809.1}.
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DR EMBL; JYDJ01000254; KRX38809.1; -; Genomic_DNA.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24046:SF5; EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SMART; SM00214; VWC; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 906..1060
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1398..1456
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1457..1518
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1519..1558
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1559..1600
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT COILED 1369..1396
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX38809.1"
SQ SEQUENCE 1603 AA; 180798 MW; 917E2C8046BD8B2C CRC64;
LKSDLLPLLK FVDHRILEHW CKTTTSMAFV WLLSFFATLI IVNSDKPPKM LMHSNEKVVV
NLKTGNVSGT GRFVRVEESF EYSKSNAGSD WSLTGDCNRR AVLRINLHSS ISLVKIIGFY
NRPQLWTLHI SQSKMQSGGC GYLWTNDLAQ SEMCIQNRRI TFHCNNKHSN QSSCRLFENF
LPSRRRPVVK LEITEKRSKF YINDAKRKRF LPIAEMVSLF PENSQNRTLY LGLNRLISEP
GQYGTGLCKV IISLLKSREK RDECTFENRT CDGEKGECQF ASGRYFCVCK PGFQKHGNRC
RDVNECEHMN GHCVQICANT IGSFKCSCYV GFQLADDQKN CLDIDECKTD NGYCEHYCVN
TIGSYYCSCE RGFVLAADGF SCILKKPSQI CDQLGCTHGC VKEFGSCYCK SGYHLHSDGR
TCISTCSIGN GGCQHNCLDT RQGTICMCHS GYFLASDEHS CVASCEIDNG GCEKRCESTE
NGIECYYIDE CQNWNGHCEQ ICINIPGAYE CACENGYLLS NDRLSCKDID ECQSNDVCDH
ICINQPGNVD ECSIGNAGCQ QICHNTPGSY YCSCHTGFVL HSNKKDCIAV DYCLKSSDET
SIISSSLNCR GNMCTLICHK NAEFVAKKMK SSIKIACSKN ISAVTSIKAA GSQWHYMDVS
FLVDRCILLN RLFRMKTNQK NFEAEKGILL IENSGKIDRY QQCGKNPEFA SIEITCLKRA
AEMQQANNNR SLSVFSAQGW YRIADAITSQ HFINFFSEIV QINGLKLRYR SSEMMLRTIS
KSSLHLLCNH KHPKKECRTL SKDSVMKTFK NMMPVACEPG NFYNTTVGLC FPCPTGTYQP
MSNSLSCIKC PSVDYKKNQS AGRDAIENCA TPCLPGHYSS TGMEPCLPCP YGFYQSESGR
LACTACGEKL TTYDFGSTSF SNCSVPELCL PGFYFNVDEN KCQPCPIGSY QFEYGKNYCI
RCPQNLTTEF PASKSQNSCI TPLGKRILLF IVQLHLAADH CGDYLVIRKN RSPLSPMTLE
ACSSKAAPFA MLGQSRRLWI YFRSDSNNSN TGFKIHYVFY SDEHHSLVED FVRDARLQAM
ASREAFFKSD HYLQLFMNVI AEPENYPAYM QLAIQDISQP VTLTKSETAE VASLLMTKKF
SILLQFVQIE HTRGTLFYVS TGNVKVFELY SSGLKGELTV YWRRQYRIAN LHVKYEFDDE
NMHTIIFELV NEDLRLMIDC IEAVVGDYPE IDFRILQSNK TTSAHVGHRG RGNSKFAGEI
RRFVITNESL AGKLCSIRTQ DYDQWKSAAF EKRITETPMQ DPILPHEALL QAENICKKLQ
SRVEILEAIA LDLKPEKGAT LKLINLPEPS EVKIDGQCPN CWEYLRFKIN YLEEEFKRLR
KNMKDMDERL KNVLLRQRGC VINDTEVDDG YHWLDQQSCT ECTCHLGKVF CHPLGCPKLK
CDHLIKRPGQ CCPECGQDCH YMGANYKHGD AFSPKQCVQC RCDNGDMSCT YATNSCPKLS
CSIEDQITPE GHCCAICKNA DFCAAAPCHP DADCINEEHG HKCVCKKGYF GDGTNHCFDI
NECQPDDGKS YPCSSGSRCI NTAGSFHCNC LPGYRQQILQ AIA
//
