ID A0A0V0TMQ1_9BILA Unreviewed; 3260 AA.
AC A0A0V0TMQ1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 28-JUN-2023, entry version 35.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN Name=Smg1 {ECO:0000313|EMBL:KRX40301.1};
GN ORFNames=T05_13690 {ECO:0000313|EMBL:KRX40301.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX40301.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX40301.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX40301.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX40301.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDJ01000204; KRX40301.1; -; Genomic_DNA.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR031559; SMG1.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF119; SERINE/THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KRX40301.1};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1906..2193
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3228..3260
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1343..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1686..1713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2887..2917
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1355..1371
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX40301.1"
FT NON_TER 3260
FT /evidence="ECO:0000313|EMBL:KRX40301.1"
SQ SEQUENCE 3260 AA; 372478 MW; 07DA8DFD519E2202 CRC64;
LHITVALKQW WTLMDEILLS YQSSIFYTVS MLRNLLFIMY SDSSSLWLSN ADSMTEAVDL
STLWSKIRTI LYATDGDVKE LVQACEQFKT LFESQANSDG HVQTSISIID VAVGFNEEFL
RCIQSLLLPL TMNAAGGEIV KLFKYLVDRI YDLRFECKQA MLLKIVSELM TTSRVILCFA
DSLYLLASLF KMQCMGFYYP NTLELFLEIF LRCFGLLIPI VGMPDDFFQI LLRLLVVLQP
RADKKKQSDR LIRVGRKVLH LYFPEDFQRG TNILLALIKV AQDDAERFKN GLNFNERCKY
SRRIWRSVSL FNSMISIFST EERQWNQHRE FLQFLNTMVP MLTSIAVLML HSSEGRRSAI
VDLATRSIAQ LHELLPAGDK SIFLKSIVEF GFLFLDPNLT LLYLDIESIL ELIKQIVVHK
DRCLFAVHIS ALIGPNGILP KLRFHQEATI VRLTMEIYRS LLLLKGDLCS IMSYRQHKIT
SVSIFNRMIV GELVVSLEML ACRGEVEGLD QQPLKIEFDN IWNGQLESDV QLSELKFILH
FNASLLMLVC RSEAFRWISI ANVPDIYSVL TGNSLLSSKW LTVFFPSVHY ALLMLLRIYC
TSYRHFSSDE ILCMLRKQGT YNFHDYVEMI KQLLMNDGIS VAVRKLLYEW INCIFSVVIK
DDDFKSAYSA DLVELAWAAV TFHCDIIKCK DEFFCMLVQI FYSQFSYPKI VREKLYATIL
LASCYSCDEC VSRGLQDILP EFSYDDPDER AIMLKMANNA QLSSNDQQPV SSHLFATLMD
FVLLNIDASE LTVFHLKYFT DTAKFMIQYC STRTEVEVLI NEYPGSVWMM ALTMLANCCI
ENRLKTIYGP KSSIALGSVT RVASSSDRTQ LADQLSAERL HSVQCNFLLY FVEILYKMMY
RCYTNIDPQA HVGLGSFYRI NWNSFDAYFR KIRPSIVGLA SRQGEYETVL MWISRLSSSD
PILDETPPWG IYSFLLNVVD AYVMLQAAPS VIGFSHWIEN KLKIDDQLIK ICSHKASERY
EITASMLTDW VMSVESGNNS NPDVVDVLSI QIKYCYEEIV DCFVKLGDWS MAATWLKRGK
QSCGVPVYKW QPLVDYIERM ANLAANLEKR EAKIDGGDGD ADQQQLVKKR PTDYRNFLCY
VDCTFLNIME NNEFGSDGME EKLHILLQDL ETRRFLCSTY MKPLSLCKDY EIRLDIIKVL
ENACRWKNWI LGPVDTSQLR IDQLTVMYSI FCMTNVLPCG REVCLSDFCT SFAKRARKTG
NLNLCMRIWR RHFGCNSTAE LCSFLLVLIA RYSQALDCAV EVAKLLWEQG RGAGCEQRVD
SALKFLTQAV AVAVWANIPS TDGSTKSTPT TADVDDVDDD RDDDDGYDDD DDNIPLAKGL
VVLASWLGDV QFGKRHLPPP NNDDAEIAFQ ALFQSKLQQL QTEFDLNDNI ADGVALSLAV
QFCRTSVKAH HHYVGWLNSI IFSLVEEKEG FHAFRLSSKE KQFITSLLSA KSKVNLDNVL
LLLETVRSEQ NQLTWNVICP DVRKVCTSSF ALEKLHEWWE ARHGHLFNLY NTLCESYFVI
LRNNYPDDFI TVDATIQIIR LVTSHYTDLK DCLHDGVLFF RDFFFSHSIY RFVFQAVIPQ
LFAHLGHRNA GVRTLFADVL CSMAVEFPAM VIYPALAGLS GDGKHYRPAD FYAEEMDSKL
NSSADVSFNE SEAEEEEEEE NDYRNELIES QFRQNCCKRI LDCLSELYPQ MVRDTTEFVA
ELKRIILLHD EVWYSLLTSM RPEVARRLRD FYQNQEQQLP ISDERKEQLK RGKTLLMKKM
LFQILVDLHE VTSKLPQTKS EKIFSETFSP RIGKIVEQVE DENCIDLNKI WDQFCQLHAD
LAEQTKNKSW LLKMEEISPK LAEMKDTMIP IPGVFENDQP VMIKSVCAEV KILPTKTKPK
KFSFVGSNGV KYRYLLKGAE DLHLDERVSQ FLNFSNILFQ SSKKSLGEAV YHARSYAVTP
LGQRAGLIQW VDNFVPLFLL YRKWQLRQGG KNVTRPSELF YEKLRTLLSN EGLHVTSESW
WKAQVNFARS MAVVAIIGYV IGLGDRHLDN LLVNLETGEV VNIDYNVCFE KGKLLRVPET
VPFRLTQNIV NALGISGVEG EFRISCENVL RLFREHKNTF VTLLETFVHD PLIDWRKTYG
IGPNGLVVHS ILSTIQGDMK LRKYVEQSRD WNKRFFLYRY EECKALWIEN RNSFNETFKT
SSEMLDQMEI ICNSIANTRQ RCAIYEAVLK LISQATENPD HSLYKFLENN QDFTGVYEEV
IASYAELMSK LKKNQELNVT YSNSISQLNN LHGFRQKVDD AFSKPPQCFI ELAVEFLRAT
GQTQKIQPYK NLESKIVPSF SALRELCNNL LDLVEAYRSA QLLVPAVDRK KHRLHVWLEL
LESVSKCSCD SGGGGGGGGL EANVQQTERL LEQIGQQQQR GGRTSPEQFY ANACRTVRMF
QSVLDNGEKM PTIRAGDLKK IFANTTDMGP VFIASSETAL VNWLASIANE MSRLEEGNCC
TKADDQGNSA EQQARGMVSF GWMDIYLTVL KYLQSVRQLL VLPAFEKFSN QSILQRLDAG
QRLFQCCVSL VEQISTSLVP TMYRMTVDNH AELSSWLMGV VDACATASTL SMDKAWQTLA
DEQLPVGMEW LEADNFDSHH LLDQLQRIND ELRVRKPIFS HRVGDEAMTV FRHCLDSFMA
IKDHLKLLLD CLPQGGGRGG SLPLPTVDYR WSIVLDFIYN YTMYRCASVA VSYAEGDQSA
SVSAVFVDLP DAVGTMLWKK LLLNSLPSAL LNNVVDLVNN FRLSTPNDVP VSDAHPMVQQ
YQTDIRNFVQ TVQIELTKDA CEVLKNALVP LNGLVRSYAW HHEIVLKRAV DPLSSPLVVE
PTCSTVLIGL NEHLDQLRNI VNELKESREE LSTAAKDTIS RLTWAAGANA TWSSKLEEFE
RAKESDLGQF NIAVELCDRF ILIADSLYNY ESLKLDSEQL VKLDNAMVEN VKLYLKQLKR
YMSIAAGMDP AEIELAKLKP SQEEHVTEKW LLSILADFEK RHSEANQALI KVQDEFFAKK
TNFHAITESV RLLLNEHRKF TAEARAYMKH LAFSGDEIEA KLANFFLHLQ KLHTLAFSDV
LRTDITSLPD TWDFEATKVA FKRAAYLTNT IFDVLIDFVD PEAASSHSKA RVCRLNYLIL
KFTVGNQSKS PNLILDVKSR SGKLNALALN AWKCVRAKLE GRNSNSEIPL SIADQVDALI
SDATNLDNLA LMYEGWTAWV
//