ID A0A0V0TY85_9BILA Unreviewed; 1962 AA.
AC A0A0V0TY85;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN Name=CACNA1F {ECO:0000313|EMBL:KRX43957.1};
GN ORFNames=T05_15844 {ECO:0000313|EMBL:KRX43957.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX43957.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX43957.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX43957.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX43957.1}.
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DR EMBL; JYDJ01000107; KRX43957.1; -; Genomic_DNA.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 146..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 981..1005
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1078..1097
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1188..1215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1269..1287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1299..1319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1387..1412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1549..1583
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 92..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1830..1854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 431
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 764
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1161
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1962 AA; 223272 MW; E1D23DBBC0FA1F97 CRC64;
MHAWKEYLCW HRESRPEQVV PSPIAEPRVA SIQTMIVRQV RHHARSEANF NDDVNIGKEL
SGNEAAALLH GDEARASRAD LWQQTLQAAV AAQTESSTTT KKRQQQRKMQ RNVQQERPER
SLLCLGLKNP IRKLFISIVE WKPFEWLILC MICANCIALA VYQPFPAHDS DRKNAVLLCA
IGKTFFDFVP AELRPAIDRQ PGTAFQNRKH KLNPQPGQRT ATVAAVGHTG WGVGLFSEEQ
VEYIFIVVFT IECVMKVIAY GFLFHPGAYL RNGWNLLDFL IVVIGLISTA LSTLNIHGFD
VKALRAFRVL RPLRLVSGVP SLQVVLNSIL RAMVPLFHIA LLVLFVIIIY AIIGLELFCG
KLHKTCVDQW TGEHVPDPGP CGESHTSFHC DRSKNLVCTE NHTWPGPNDG ITNFDNFGLA
MLTVFQCISL EGWTDVMYWV NDSVGREWPW IYFITLVILG SFFVLNLVLG VLSGEFSKER
EKARARGLFQ KFREKQQLED DLKGYLDWIT QAEDIDLVNE EDEEQEAMDR EEFGADGEGG
EEGGSKEEFQ RQSWFSMKIK RLKKLNRRCR RSCRRIVKSQ AFYWLVIVLV FLNTMVLTSE
HYGQPEWLDH FQEIANLFFV VLFTLEMFLK MYSLGFVNYF VALFNRFDCF VVIGSILEFA
LTFAGLMKPL GVSVLRSARL LRIFKVTKYW NSLRNLVASL LNSLRSIASL LLLLFLFIVI
FALLGMQVFG GKFNTIDPNM NKPRANFDTF VQALLTVFQI LTGEDWNAVM YNGIAAFGGV
HSIGVIVCIY FIVLFICGNY ILLNVFLAIA VDNLADAESL TAAEKEEENK RANEADPEDD
MVVKATADED AVSVGQFHES GEVKLPFNEP TDAEDEHLAS GDDDQEREME NQSQFKPTAR
PHRQSELNLP KKTKPIPDAS SLFLFSSTNK VRIFCNKVIN HSYFTNSVLV CILVSSAMLA
AEDPLQASSF RNEVPKFVLN YFDYFFTTVF TIEISLKVLV YGLILHKGSF CRNAFNLLDM
LVVGVSLTSF GLKSGAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVIV AVKTIGNIML
VTFMLEFMFA IIGVQIFKGS FFRCTDRARL TAEECKGTFI EFEGGDVTRP HVRNREWTNY
DFNFDNVQNA MVALFVVSTF EGWPDLLHVA MDSSDEGIGP QYNARVSVAI FFITFIVVIA
FFMMNIFVGF VIVTFQSEGE REYENCELDK NQRKCIEFAL TAKPQRRYIP KNRFQYKIWW
FVTSQPFEYA IFIIIILNTL ILGMKHYKSS AAFDEALDVL NLFFTTVFAL EFICKLFALT
FKNYFGDAWN VFDFIIVLGS FIDIIYGKVS VPTGEAWQLI MLSCANTPAA MCDPESDDRG
QPCGNDFAYP FFISFFMLCS FLIINLFVAV IMDNFDYLTR DWSILGPHHL DEFVRLWSEY
DPDAKGRIKH LDVVTLLRKI SPPLGFGKLC PHRLACKRLV SMNMPLNSDG TVCFNSTLFA
LVRTNLKIYT EVSSNIEEAN EQLRAVIKRI WKRTPQRLLD EIVPPSGRDD EITVGKFYAT
YLIQDYFRRF KKRKEVEQKE TNMQGNITMS LQAGLRTLHE IGPEIKRAIS GNLETDWSKE
FEEPQHRRDH SLFGTLVHAL QAHYKPFIEG NLTNPAYSNV NGDLKSQEGF LNSNPTNLYA
TSRNGAVIHF SPTYVVEWTA LVLFDSDHDS SEHEMQERVR FVPRGSKPTG LSFEGSRWLP
RKLSFRRTPI GGAAAVSNLQ QGNNKRLQFS NAIILDDSDP DSVLHSENVV DLTESGDDSK
LSVSPPLELR DDAYYLDGID YNTWRPAPMG QGVRLRGRGN GRRKSRSMPL PHHEHQRNYA
DVLVEKVLAD QGLGRYADPN LIRTTQLEIA EAYNMTEAQM HSAARSLMQR SPKYFEHMGG
QRPADIKDFN QYSKTALLKP REINSSEEVD ISDDMNMFMS VV
//
