ID A0A0V0TZ05_9BILA Unreviewed; 3528 AA.
AC A0A0V0TZ05;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Histone-lysine N-methyltransferase 2C {ECO:0000313|EMBL:KRX44236.1};
GN Name=Kmt2c {ECO:0000313|EMBL:KRX44236.1};
GN ORFNames=T05_934 {ECO:0000313|EMBL:KRX44236.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX44236.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX44236.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX44236.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX44236.1}.
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DR EMBL; JYDJ01000101; KRX44236.1; -; Genomic_DNA.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd15512; PHD4_KMT2C_like; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00249; PHD; 4.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:KRX44236.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KRX44236.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT TRANSMEM 3036..3055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3113..3137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..216
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 213..263
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 290..345
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2167..2275
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 2542..2658
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 2666..2682
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 2869..2919
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 86..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1556..1599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1687..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2909..2936
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 90..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1200..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1584
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3528 AA; 396009 MW; 9831E3FD9A719363 CRC64;
MQFNILQKKT SFLNAHATMK HWGYAFKEAY LRFKFKITHL IVVYYLSDEV DLSYSHTSVE
PISLPPQNMI TGHALPENVS RKKISTFKRN SASKGKGGST SSRSIVDKRR SQKCAKNRRN
AVQTITEILN HHLAPNVAKH KEDDEYIHSV VVTSVKDSYV FCRDMCVVCG SFGRGQEGHM
VACTQCGQCY HTYCANVTLN SVIVHRGWRC LDCTVCEGCG TGDDEQHLLL CDECDVSYHM
YCLDPPLDSI PQGAWRCKWC STCQFCGATP PNGMLDSIKN LRACFKCASL YSCCFCHLQY
KEEDMIILCD ICHRWSHANC NGLCAEDILK KGLDAGFICV YCRPGDACSS AAMHFVIEGV
LLTKSGLSTV QWRPKPAASP VCSAVYNSTR SFESLQNATA DGFSELSTSQ IMIQDGVVSA
SPDMEKLDFE FSSNSDMTIY ESQNGLDSFG SVDRQKRVRN RKLFKVGIGG FHTRLARSRY
DKLQEECVAT ASPEMMGNSL GGNAQLDNNA VAAGDSIVEE GHDKPKRRKR NRRKVVLEDY
YPSYIQEAFF GISAEESSYT NGGNVNGPAP FPMSPFDLQE QDIAFAIPRS PDTEINSEVI
KNAESSSQVY KLRNANVLPE VCLNEAIDMN ENEEIFPHEL QNHDFTNLLD MLMQADMDPI
VSNTDISAID SVEMDTLMDN VFDAELKRAS ELTETQLLAN SAAAAAEMHQ PNGRCLKDLT
AMCGDNAPTP FVSLPVEIGT AASQQMAPKN FNEQQTDLIG NMAGNIFPNS NNSSNSNNVN
SDNMIGGGMV ESTAVRPRMC ESPPVEAKNY LDRWLQDEPL GDRSSIAAVL YANLNAPDLK
TRYPCWPDRA KCIAKIWRSL NQDHRQQYVQ MARENRSLMR QECKARRQQQ QQQQQQQQPC
LLASSPAVRR SSSSGGQLMK LIESSSPPSM VNCAATSDTA SNPMSGATPA PMPLNISVAD
ETSHRADIPM KPHFPVIRDF FPFQQRLHNQ HHPNQQHFPT HLIHHNHQPQ EDQQRQLKNF
TMNFSQREFF QNHDGTAGTV AHHQHQQQRK FSLPEDGLAF AVQKNDVIKQ PVDHQYGMMV
NSGESFRLGK AEPLDALGRR ASCPSSAEAL VGMAACCNNS LSSALAPAPV LSPSQAQILT
REMRSPPVSW SQANRIDHHH QQQQQQPQQP QQQGQFGCAA QAKLLPRTPV VGDGHELMTG
MRNQQGQNHS NKQQQDNKLA QVAQSVETTM HEEWLMQTVG SLEHQQKSLE SELNQLRRTK
KNTASKQRQM RKNGVEPPQA DQAALASLTQ TIGERQKLLE RIRKQLKTHN SLVQDYQQQD
KRVDGALSIA GGGSGQSSSY PAPAQSPVPS PAYQPAVSPM DCGFAAEPGH TAPPRSEQAF
MAPTAGRQRH FNFVQPMLVD HHQHLPQQQQ QQQQQQQPPH YPQQQQRHYE QQHPNLHPQS
ALTAANFGVL AMNGASGLVA GQTVAPEPSP SAVGAEMMKP TMMNITAPPY YQRMVPVRVP
LDSTVAVAPG LAPPPPLPDP PLPPEFAAAY VNEGIIHYSM PGRRFAPHPL GDVAVGAAAP
PPSLPVQPPP AQAAPPPPPP YHHHHQQQQP EVKKRKRIRR KKSEIKEQIL TCCKAYDGIP
DDETVLSRTK CLNLCSMSRC YGSEVVATVK DLLDRVSDDE YGEATEAVLH MFSKIYPTDQ
CYDFDGSRRK GKGQLSRKRS RRSNKAKSFC GNEDAVDEMG ELTDHQWFYY LQQLPPLTIV
EPESRFDTAI THFYGVTPLT DCKGLVEGTL GKVTLSFAED YYRRSCGGDG ARNNSLVRMA
ESTTRGQIEK SFSNVKVEND FLFENRSSNS PDELIYSDGS GDEENLPCYP YLKPEMSADG
RLSPNFRLVA PVPVRAVPGD PPAGALNKTI NEYVQSQQSR VVTLTLDSAA ASNVSNVLRN
LACLLNVDVP ELFDLQIDTP PHTPDRVLSR EYAETQRRFC CYCATALQQA MVKKNLAELG
FTPKNDDSDE VVFCSDACFV QFAVSRKMPI SPGNPSKVLP NKTVITSGFE NALERSNSSS
MSICTANQLR IAESENSRHR LVNNVKLDEI IRSVVGTSKV YTGTSKESVV HVRDLPRLKD
TVEVESENQD ASHYESKIEK KLKGARWQLY NNCQKSLLKV LACNTPEALW KEMLSIFWLP
QSLPQDTRIC ELCSRMGDGE TEVCGRLLNM DAGRWVHVNC VLWSAEVYET MDGGLVNVEQ
AVRRASVTRC VLCDLPGATI PCYKMKCGSN FHLHCAVDSR CTFMMDKTMF CFEHPPLCRD
KILYNLAVFR KVYIERDDEQ LLSKLYQQSE SGEYAMRIGS LLFHHVGQLL PEQLNRFHTK
DCIFPVDYTV SRIYWSTFHP RRRQIYQCHI GEFEGAPLFS VTAKYPGTPE VRYQSKSINE
VWQNNILTPL QGLRNCNDIL KLFPSYISGE SFFGLFEPSI QKMLESLPGI DSLVTYEFKY
GRSLWMEPPL VLNPSGSARC EPCFRTYIKR SRKLNAMSAH SIQSLLAFSG MPSDGYFYSF
GNKQSLVAKC YQYRKLKQEW KSNVYLARSK IQGLGLFANR DVEMNAMVIE YVGEVIRNEV
AERREKSYQK RNRGVYMFRL DSDHVIDATV AGGPARYINH SCDPNCIAER IDFDRESRIV
IMSCRPICKG EELTYDYQFD FEDELNKLPC LCRAPNCRNK EAVYMKMQTG CASCVRFTTF
AEGTILALRM VSSQSFGYYT GGQHVENFAP NNACMASSPN EEFYFAVPDE QQQFVSSGPQ
ATTYWDNSCN LNVVNPVEFQ WTTDHYYPLT NWNSAPTAAA AYTHGVGNVV DEGAVPARTF
IFNGQSCWNL MAEDSAIAVV KNNQIEEADE EELASADTGT VSKNRNPCRR RCAHSVIERR
YRSSINERIA ELKTLVIGPS ARASKSTVLR AAIDKLKQLK QLNDSLRAEN EQLKACCTCS
PFSLSMHSLD FGQNNFDISV SSTEELNNNS NNSSVSTNSK FTLFLLFACV VIVNPFHMVS
QISTVGVAPL GKLWNAPLLK SVDISRIRAE IIENNILRIL LLSVINGLVV ALVIVKLRFC
RRLILKDPTC PKVKSRSLTV LGDDRGREDS PPPVPAPMVM RCSQFKRTFA EQLLQILLTF
FHFILLPVNL FCLLSNVDDE EQKSADMGKF HYSNPTTLLQ HFTDDKPHLS RFADKKRYSS
IELALNSVKL AAKVDNKLEK PILVNVYCMA ALQIRLLPWI GNSLAKLLYN RANQEYRKVE
SDLNVCWLFT SIGKKFFFNL NLNDKQFWLL KRALLLNSKE TEEYLNFVKH SRDEFKKKRL
FGVTMSNQET DYFWYVSFIL FGFGQDHRAS LMDERNLLKD IQELATSAVQ EACCKAAIAC
HLGTSSENKE NIVCEILQLC MDVHQSMMSS SVADYPLENI TLVLAVDWCL KALIVSSEMN
VHLLVNKNCT NADVNGKHMF RLLLKQKRRF ISNLQPFLSR ETIRYEAIGC LLDGMNPTFV
QKLLMKYAKV DQFDRPWTCT NNSGGIEKWL FSLGPQQWLT SLLLSEEN
//
