ID A0A0V0U1G2_9BILA Unreviewed; 3208 AA.
AC A0A0V0U1G2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Lysosomal-trafficking regulator {ECO:0000313|EMBL:KRX44743.1};
GN Name=Lyst {ECO:0000313|EMBL:KRX44743.1};
GN ORFNames=T05_15545 {ECO:0000313|EMBL:KRX44743.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX44743.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX44743.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX44743.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX44743.1}.
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DR EMBL; JYDJ01000090; KRX44743.1; -; Genomic_DNA.
DR STRING; 144512.A0A0V0U1G2; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 2394..2497
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2504..2803
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3015..3049
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 2804..2827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2804..2821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3208 AA; 365171 MW; 8EB34D9886792E64 CRC64;
MSDQFTTFEN AFLKKVAISQ PYLCQFLVEK FEEYLYVLNE GILTSQQAWP VLNEDYLPLC
CVLSLCKWKN VQKPNSMAEI VWNVIKTLLT DEDESVTFST PLSEANLKLL NLLFHYAGDQ
DLLEQKRKLL DYSSVVRRTA EDSKKSNFFI KERRAYVKWK RSRRMCLDDS NFSNERQSNI
WKPLYCTSTS SGDVSESGRP HGRISRMKHD SSSQPCLETN LWYWFVEDSD GFLWDSSVIF
HAADLTHIIG RQLRRQCRLF QSCSFDQLDK QTACCILLNL LARCINWCST EDAILSTIIH
DCTEWILQSC GVLSELHHTD GYLWLVRFVC KLISWMPVSG DYYFPSIRIA QQVNNFVWKL
LQCIVVDQLH NCIPSTAADQ SELLSGVIFT ACRAVVDNLL ILIFQMSAQR HLCDRMPALV
DLIDSSLSSR MLLDIPLQVV SSDVPRLLSS LDAWNRYLRD ALVAIVDRLL KLNRLAQHQG
WCSKSKHISC GLLAVAEEST DCITSVGSCC VILRIEEIMF ELVRRTRDNA PDDRFHMIRA
LFEFQSCSCS GVVRYLDLLV EMLPRCGSAV DRRMLRRCIF GKLLKQRSNN TLWNDCERFD
LASSFGQLFD QLNLCEQLPL LNLLTEAASK LTSDYKAQLF AGFALPQLLN ACRTDNFPVR
LVRALYRLCS TTITASNYPT LVEHFELFES HLREIELDLV SAELLIEAAR VERHVQEPHL
VSISDRILMQ TIRVLNLVIS DVRLLAMDNC NDRVTFWSAP ARLTYLCSRL WSLPHFAVSF
CQRGGVELIH GLVASVIHYS TRRRLDLDAT FFSYVEHLLY ITVGFCASIT PADSKIANTF
FSRVRNQLMG DLTERNPNNL LAVAEILLRT FVAVQLAESG NLLDRIKVDS GSSSGMSTQS
EEDVAAYSCV SYSSAKETAL QIVGNSYSIE KYSLAIGQWS IIIVAGLLKR GIENVGKFFQ
RLQRYCVRYP TMMKTLLEHP TSIENFTTIL KTIPQCWTCE HVSPILEAML TIFLSINDHN
GLRLAFQLAD QYGSHTVLTL LRILDQSLQE CKFDPKYLLP LNFPWPDDYS HSSCSTTASA
LAAACEKKSS GQQLLDLSFN STCSSYYTSM LRMIRMKTSA PVMINLKKYV KRANMRQGLS
VGIWLRCGIV GNFFNQACKR REQAHVVSIG NAKLLCSVNV GLPGLELILS LNFNGQQVVS
YKCGSLHADR WCLLFLQMRY ANQKLFIQLN FNDSRIFRRE THWNAEGDDD DDDDDEEEEQ
GVEDGTDAFR HFAIALFGRR KLFRLFGHVA SINVFNECLS DNYCTLLYEL GPRRCNLALN
ENGELLNLNL YCCSSKRKLY SLFDDEDALI RLSERLVAVM TGQKMIQFCA YPNKRYALNC
LCNVVVDHDD TTLSDRQQQT LLIDIVDPCG STQLYNFLQS CGSVMILLYL VIQVIDCPVV
LHKPIDEQSR SFALRFLVLC VQRNPIWRDE FVKMLGPAML SYFTGESQFP VGSDFVKTLF
DLCVSCSHSG CPLICEVEIL FQMLTSFQLW RNGLEQFAEA LLLLANLLEA SSENVTICNQ
FSLIKRLLNL ICIYIRITGK DFSSSLINAI TRVVQAVLSA GIWFTEVSVV IEFLFYCHDA
SRVTVQYPFC NAFTWINLSL IETFVNGLLK IRDECENELL IKDDCGFMSS MHLYDAASIT
KQLHNTTISD VFSKYQLFAS AGKMFFELIE PSLRPSSKGI ETFPAFVRLK CEILHLLIAH
MNNIENGEQL TNVPNCDIRW EYLIVMLRQQ VDRQTVGYLV ELLAVTLHWF SDDQKEQFLN
ARGFDLLRNQ LYQLPTSITV ISSLLQLVLG GQTSYFSNNN KFEDQQLFQD HISNLMTIDE
FQTEALSVLV AQLECAIVDC TTFNNLIDLL TEISKNDQIA STLWRVGLTD CLVAALMKLP
RLNVEKDEDR QQQVMVNVRG AWRRFAVSVF RKALLSAEEQ VFKCAAVGFL ELLMLADLQL
YVGGKVVKQR LIRDELVNLL GELLTTYRQV SWLKRWDDRK SSTSCRRHRC SSGEAGESEI
MASRLEDRLV ECLELCNNFI LFMPPNVGPD NDEELLLFQS YFSFLIDLIP DSFLLTKDPP
NGPKKRLAIF ALVKNLFVFL VHPSILLTFR QLWDRLHGNF RQTAGNCCDC SRRFVMVEQL
QRNPKAREVL KSFLSTLPEY RDLLLHIFCD FSVCTTLTEA DKAALAAFLR LDFLQASSVS
SSKLSSSGQC KIELAPAKSS LKKFYHLTCS WVSGMFERKK RILQDSQARL HSTNEQASDV
NRFTVYMHDV ITSEYASFEH NSNRLAENVL WQWRFIEKSL CHPQGIFYSP KKWPNRWYLD
PLHLPGYSRV RFTPDVMDND SEFYRSQETG SSIKGCSSFW LDKLFATSTL LPFDTEGGVL
HSFNTIMVTL FFEATGTLLL YRDKIHFLSN NCCTVQKRIP LNKKVSTSWN YSQLILLNCL
RFHAADSAVE MFFDTLESCL FVFDSPANRA EAVDHLKTFS PSLQQQASLQ MLSTFTEAWR
YGRMTNFDYI ITLNELAGRT FNDITQYPVF PFILNDYLNY TIDLKQPTLY RDLSLPVAVQ
NSKSRTYYSE RYEALSSASL DQNVPLSEPY HFSALYSNSG VVLYYMIRVP PFSNLALEYH
DNTFDMPDRL FHSINTTWNM ASWDWRGDNK ELIPEFFTLP EMFINTQNFN LGIRHNGERV
HDVIMPNWCP EKDPRLFVLI HRQALESDAV SKRLSHWIDL IFGYRQSGQA AVEAFNVYHP
CTSWKNVRFE ELGDEIFSSA LHAMVKTFGQ LPLQLFTKPH PPRTISINND SNSTTASAAA
PRPPPTSEYS FCPARGLRWG NYVGSPEGQA PRLICAPTVV IDAPSQLAHV FILPCGNLVF
VPDKVALVAV YPCKLNPNRT FFSSVRQQVR LRTPVSIVSL RFDFADCVIK LKFEHLPTSA
GRISESDSSE LNDLMLAYDF QVTAYSSFVE TTVFCFGTDL GTLNVVRLKW DYLPNVVKHL
QPQNLQANCT VLKTLYGHSA SVSTVAQSTE HGIIVSGSAA GELFVWDLNR LCFVRKLTGH
EGTLSLCAIS SGSSSSCDIV SVSDEDVGSE LILHTVNGRL VGRVHSSVTI CSLALSTLSE
GVSINCIAAG LQNGVIKIWD RWKLSLIQEL RSDEVLRPVI SLAYTCNCSQ LVALLNDNTI
ICWDKNADTT KSATNHFKER LSRALRIT
//
