ID   A0A0V0U211_9BILA        Unreviewed;       744 AA.
AC   A0A0V0U211;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   03-MAY-2023, entry version 20.
DE   SubName: Full=Rho guanine nucleotide exchange factor 16 {ECO:0000313|EMBL:KRX45264.1};
GN   Name=ARHGEF16 {ECO:0000313|EMBL:KRX45264.1};
GN   ORFNames=T05_613 {ECO:0000313|EMBL:KRX45264.1};
OS   Trichinella murrelli.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX45264.1, ECO:0000313|Proteomes:UP000055048};
RN   [1] {ECO:0000313|EMBL:KRX45264.1, ECO:0000313|Proteomes:UP000055048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS417 {ECO:0000313|EMBL:KRX45264.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX45264.1}.
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DR   EMBL; JYDJ01000079; KRX45264.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0U211; -.
DR   Proteomes; UP000055048; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000055048}.
FT   DOMAIN          384..574
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          677..717
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          259..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..275
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   744 AA;  85180 MW;  2598F447B4F60D45 CRC64;
     MDTYTRRQNG IEEGKTGFEF TFFTGKPTSQ KCSGVGGRFF LFRPRSSFSN FSTSPHLHTV
     NCCSNDRSTW TVFGDPNSKS TTSPMRFSFK FEKIELVRSK SSRVQIFLLS ISNFSSNRSN
     VPSINFDQIQ IRIEINRECN NNLHCKIGPI EEFRSDIGKS DLKKEIGDEN VTCNRVDWTP
     KRRRKNNLLG LDEAFSKLKL RGNRQHCDQS ISKEKCISNF PPKFVPKQSN NRNSDNRTIF
     STPPPELVVV TFDSNFPQSN NNSAEQQSIS PRNFTKEKYN GKRNLNESEE CKLRVKNIKQ
     HKVFPFESYC SSLWRRKRSK GLPGSAEVSY MKNNKSQQIE VSHSLLIVML KVPPVCRLAN
     LEAIVLCGTI DLGVLQTMGK DSIYLQEKIF EIVTSEASYL NSLLILTVHF MQSPKLSGKT
     DSESVITAQD HKELFSSVHA VRHSSERLFK KLKQSVETSV MLDNICDILA DHLQKDENVF
     VNYCRDLAYQ QKKLHYLKEN NAKFVEEIAL LEKSKFVKNQ DLASFLLQPL QRVTRYPLLI
     RAIRSQLNAN DKRIASVECA LSIAQRVVSL CNESRRHFQG IEELFELHSK LIYNHQSPKQ
     FPVITRKRRL IMKGSFCASE IKKSKTSSAN ALLITKQTRD NFLVKDYCDR KSIAVPSFSF
     DPGTNGQTLL RFSASFEHKF LVVLKSNHLN AEVRILLATN SQEDKEKWIR ALNDPSYHCT
     VDISSSVLCE NLPNLFSKIK QSTN
//