ID   A0A0V0U217_9BILA        Unreviewed;      6188 AA.
AC   A0A0V0U217;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Intron-binding protein aquarius {ECO:0000313|EMBL:KRX45260.1};
GN   Name=AQR {ECO:0000313|EMBL:KRX45260.1};
GN   ORFNames=T05_13004 {ECO:0000313|EMBL:KRX45260.1};
OS   Trichinella murrelli.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX45260.1, ECO:0000313|Proteomes:UP000055048};
RN   [1] {ECO:0000313|EMBL:KRX45260.1, ECO:0000313|Proteomes:UP000055048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS417 {ECO:0000313|EMBL:KRX45260.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UBR4 family.
CC       {ECO:0000256|ARBA:ARBA00009970}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX45260.1}.
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DR   EMBL; JYDJ01000079; KRX45260.1; -; Genomic_DNA.
DR   STRING; 144512.A0A0V0U217; -.
DR   Proteomes; UP000055048; Unassembled WGS sequence.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd17935; EEXXQc_AQR; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   CDD; cd19671; UBR-box_UBR4_5_6_7; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR048966; Aquarius_b-barrel.
DR   InterPro; IPR048967; Aquarius_insert.
DR   InterPro; IPR032174; Aquarius_N.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR045189; UBR4-like.
DR   InterPro; IPR003126; Znf_UBR.
DR   PANTHER; PTHR21725; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR   PANTHER; PTHR21725:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR4; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF16399; Aquarius_N_1st; 1.
DR   Pfam; PF21143; Aquarius_N_2nd; 2.
DR   Pfam; PF21144; Aquarius_N_3rd; 1.
DR   Pfam; PF13764; E3_UbLigase_R4; 1.
DR   SMART; SM00396; ZnF_UBR1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          1503..1572
FT                   /note="UBR-type"
FT                   /evidence="ECO:0000259|SMART:SM00396"
SQ   SEQUENCE   6188 AA;  712728 MW;  4EFC158D7A232D3E CRC64;
     MPPPCDVWWD VMVPMLNPSR RSINAAYLGA LSRVINANIE EFMKHDDEYN SFYNSFMILA
     LEHLSSNLDK VSVADYSEVK IACKNGLKYL FLKERAVNSV ELKYMIAVLK SCLTGESGLE
     RTDIYYLVAS IKKAKTPSSF SQPDRLAVGE TAMSVVTGSL IHQVWFNHRD DRIDSDAAVC
     TNAKSADELI SRFAYKSFVK NFTNENTLLA EELHCSELLL KHFMNFKVIR QMRAACQEAV
     KRNLPIWGSV SGDDGRSSTF SKLLEMNNIC MLSVGCLGIA VAIDCEKESS TDPGRIEKAI
     VVANEVFNTR KFYAECEAVR LTVLNFVSNR ILLIAKIVSE MLRYSKGIMK LSSWPLLLEI
     FCETMTSFNF SRPEFTADDD GTGGESIHLF SLVLQIMRTF LLTIFAANEY KLQANREFET
     AASRENVTKE EDDDNSEDTD PAIGRWLSAI FEEVPAMIDD ELEKCKLKLE SQQCIVADMI
     TAFGKVMQLL EIAPRKQFIA GRYLFVPTES DAVTLADIVS DLCLLKNSES YKIEAAVLPL
     VQNLLCESVI DRSFILAFLN RFGINFESSG HLIWPLQLNS IKVNLLAYVV LCRFMSIDPF
     TNERIARPIW NRVMKTLELN YKCDNNQVDE PFDANIMHMN IEHMQFLLLL FYNEPAESRR
     ELTLLSLRTL ENLLLCDKSC AVALAVLSRL LQIVDCILRF DENPPVEYLK MVYENLFPVP
     IKSEDGELLP PETPTSVPEV VHCMKKSETM LGYFYGKGSC FFYNLYHDEP GNECRVRRIM
     FLGDDAILSR NLQLALADTQ SRFLSSSWLR VDGSAPFAAY CCYYIRRILL YLAPSPEVTE
     ICNVDRPLLY EHQSSCLLLL ASRRCYLTPN VSVDFETTDD SDAAHKQRAE YLKRFDFRAL
     FSCFMRCFDR RKKTVDEIEF EDSYLMENYQ YGNCAVVVDL MLIELRCYLR DLLEYNDEPA
     FNFQLDFAET MNMVCLLVRQ CVEIIRYLIS CVDVPLQLRE QSLSRWHKHC KQLLNIVGDY
     GPDVRLLHKE VVGAFSASLR KALRVFKWDE YGSGSSKGGD FFHHNYEEIS HFFEVDQSAY
     ISVVFSQHLE NISGASIWDL LNSWKHVLFT ASAVLHDYLN RCSPELSVST EIWENLRRYF
     VLDTVLAFWP TKNACMERSF HLVEINRVSA FYEKFFNFLR HSVTTWVKPC SISEFIFANL
     LSYLKDEELG EKFFQNRSVV ELIMPLTNLK SSAIINPIYV IKYLSVLLKI AINSLNRESL
     QGMSSSNTIL KTKQTISALL NNATVLSDAM QVVFQHTSDF IEIEDQTKQR SHCESAFLVG
     VDFVNSLTLC LISLKEAEVG ELARYFVHLF LSIDGVDEYF FNLPNSSTYS LEQPLNSAAV
     KWYCHLLRLA KLNPGNADLL IFEHFCAWVK KFLQMDSLRS VVENKYWKRD QMELMDLMLF
     LTCYFTFLIG PADAFLIRKD TSANGQLCTS SADDSDSVTN VQETNNENSK VVAIDCFAAT
     RTGCCSFIVT GRHMCLQKKY YCYDCSVNGK WITVCSACAV KCHNDHDVVY VGNEEMFCQC
     TDTLKELCKA SLNWRYYYSK YLHEMDAISN VHTISDANNI HSLNNECKSS TILFDRDCAF
     SFGELTTEKE FLKDKNAHFA SIHKSMIRLF HLLRRAIIVT KEAITPVGHM ERLTESFSQF
     MRRGIHSFET TRLITMRLAQ LPAWRKQLVR DDDNLLLCRN CGENATERPK YFYKFCILNS
     RKSLIAVSAY KKCITVFPVK FPLSRAALKY KSGNWKIDVE KELEISLTFK PTFMQGINGN
     AAIFLIGGAY DVFIIALNYE GLLDSKKMLK LDMDNGETVR RAFWMPNSAS EVVLVTTQRV
     SVYYLWYSYE LPVYCYRLYS GAVADATVAY YEENCQSEKC LTRFIIIMSS DGRLYVENIG
     QSQTIPKQDR LKYLRDPLNF AHPDWQGVVV ENLENCGLSV HYSHCLSTLF FSYSNGKNYY
     CSFSMGSLRN IRAVEFSDAR KQLVNIKSWE DVDNLPGFIC ARPVEYGPIL LKFDGPKILV
     DLQCFSSSPR VVDLKSCLVW EQHTQPVNNL VCTVIATLSA TCSLTLWDVD DNCRNYWSGI
     PLTSSALCST QFNQLEECAP SILSCRKSLY PAPVDIFERS SLLDNVKLFS EDVLDVATGG
     GWFINKQPLH FVKKTGAATL HICNTDKSME ISGVKVYIDC SEKERVPSFL AVANQLKYVS
     SDVSRWYDFP LTYEESVNCC SEITLWVGEC SGDIMMVHSV HLYGRSRRLQ LSALCDNLTD
     SRQFSTFGKD DSTVLELFNG LHCKQQYTMA CVGLQKAELL MGAVCNFIRL YHMNDGMQER
     KKFFFKNLNL NLDKFHQLLT FNSTLFLKNQ AKCFIDHFLS MPDMNRVRIY KQMLKNMEFL
     LSDPEILDMI VKRLRKMVEK RPMNFLRLVF RNNGDSQLLD RLMVLFWEAV VNRKHFADTA
     PIGSVVFHNM KSFVGCIVDI LFSSMHLASF AQLKKFCAIL SDMLIGDRTE RHLSYMCSQA
     IQRNVLQAVG YFCHKQFYCE NGVQCEEVSD SQDGQEHASE LFTVDVISLK EDDIVNYDFS
     TLGDYLQKMK RHASNQDSHS VLFPEEQQGS AMNFRLMVDT SNFTSLGEHT DKGLLIFSSD
     NYQFNILLML HYLTPYFGEC SGVENIHFLQ TLLALISAVD ASNLKYAKPF LSLVRMWISF
     IDFKNSFCQR TPEAEANLMK LRFINILLNR MNDKISGTIF SFLMDEGILS FCYDVLENMH
     PKLANLVIND ELDDEKDVVV GHHFADDLWP FFLHDYVEKN DSNLFVLFDQ LAVEIALRLP
     YQLKRLVVRP EVKERLFSSN WIHLLIKYVR CMKASNLCIQ VRKLLIYICG SAELCRWHTD
     RCIFDDMLNN VLRHSRYIFS ERTCVSASQL NNVYHLQMCS MMWRLKICLR IATGRPLSFQ
     KFLLANCKIL QELLFAVAVR IHRNITKCIL SLLSVAFDAG SNNTVSGSFA FSPEMARTLA
     IAVITNSGFS ALEQFLSTLV LHTREGPQNI EPMQFFQNLM KFAPAHLAKD FVLYMWRKIV
     PRFAEYGCRL VHLIPLLSET LVFLTDSEVK IIMNDIVDYF TEERQALLTD PIFALYSKIG
     KQIPIDGFSF DKRPCFACHR HLTSSTELEL STLVKFAWYN STTEFLELRC AYEIERIVLT
     ITQKMPVKMI KHMRVYYSSR ESLSYVDITT MSYWSLAMNC ELVKDQQTVV IDFAVPITAR
     YLLIHYCEFY HIKPKPPPLQ TFFNCENCMN SYPDLCTGCA HVNLVCESCD EVNMNERAFL
     CRFCGRSPHA TLNYTVRARE SASLSPVTNR SDVQSALQEG NLLLAKIENA LTAMANELKE
     VEQLLEVSVL SAEHDVSEGT ETQASTENSV NQNVMKASRY EEYLNMYQSR CKSIHRAIIL
     NYETLILKRM AVFEFEHGKL DDSSLTSQYL KCRTSCYCCT LWSCNAVLIL IDQLLRKVNF
     DISLFTSNVV TNAFYFFSHL RKYYCFPVKQ GFHGKIVTIV LNCTPLRSDL VCQSILYNLS
     QKYNFISFDI SQRLAEKLFY LLVNGTNDCI GDYLDIMYNC AIAEGRSSDV WSTTMADVFK
     VALCREQTPT AQSILGVCLK LFASCKFIFL NAEENPRLNY TDADSSEYGD LANLKCDLRQ
     IFKSVIEKPP YRKVQSVSIH GFIAIVIKLL TYEYSRFIRK MTAKYLLTLM NEPGTLRVKI
     FENLLNRMIP LLSKCEDRID EFFGLLSELF DDPSWRSFFF RRGFFSTFLQ VTSREVERLH
     KLDRSPLSQV DLDYGCLLLN VLKIFDKMRS YDELKDHLNR RAGATFLYGH AVLRSLVFKR
     SGSVEYAQVY FKVLMDCMKS GGAALVRSYA EAAFELLRSE SAARNWQHVL HICDSIRSVI
     YPETKRVEQF QIRILQDSFQ ENYLRSSLHN RIYLSTDNGM GPRMRDIKNK ICRDCQMIPF
     IEDDNTLELI VLGKVIALYL DVAEVYKYLW LPERGRSPMI ITYRIRGLSD GAGEEYVWEL
     PTTEETDLSS VALIHQIRGE AALVKCLDAV DVFEKHGVCS VIVDLLRIAS MVRENRLALL
     SPEINAIPVI MTKVLLILMD DIKMQGMISD TMLRIICRLY EDADLFSAPE FEKFSRYPLT
     ELVISLMDVV RNKRKSIDER SEELVMRAVA LVTMGNKERI DAVLEYFDTF TDFSRYDKSS
     TPDEQKMGRM LCFFANGLPV LLFVESANGS RIREAFFNRG FTRRAVDYLS NNCPSVVHQL
     SSSSSEMEAF LRKPALDYVV KFLNDICRSC ELNQVLVADN CLSIVHTLEL TPNNERNLGN
     LSHQLMVQLN ENRMTSHKVA AVRERTRLAK KTIATESRKV QLTKLGMRMS KDGIVQIASS
     VYLNVDLPDE GHFACVICQE GFHVSPHQEM GIYVFMKSLS VRDVLLDSVD GFIPDLVGPS
     TVTQFNLVHY QCHSNSVEHA SSFRYEWDSA RLHNANTLCN AILPYPGPEI ELNEQLFMMK
     RYEMQFNEVF PGKLLSCDLV INDLKCLLIR FCWKKSFSTD SHGGGPESNM HLIPYMLYLA
     GLTLIARDKD DDDDGNRLRS NLSQFLANGS EFWFANAFDA NGLFFQSTLF ILYHDHAAWA
     AHRLDILKRF ICAGHHHALF HQDSQKEEPI EFKNYIPYLI YFALINSIYT HMFKSVSSVL
     PGTDDSWLKL LLMYISANYL DLYDSSTQLF TTYENHLLRF TSFFEFCRIC GLLESIPDPD
     AFFNNCLSML PSEFGNRRPG ASTMKSKRSV PTVEEMAHEK LTRIAASYWA NFGNAHRPFS
     AKVVADIYKN ELLEKNFAVR PIVLLEFSQY LERFLWPNFD VNTATVEHVM SILVMANEKI
     RECVPLWPIF FTREKEFEKF FTRVLEMSLD DELLTIAEQL HVVIFLNHCF TSVEIVSIRT
     VVQKIISLPM WICLPEAARE QCLNENMKLK KYWKYSQKQF DKLDEESKRK TLFYWRYICD
     LIKKFLKILH SIPPEDEQCD LNSIRYCERF LEMLIDMESL LPIRRFLNVV LLESRILCHG
     ALSTLVKRQD GGLFTELLST LKRCVYFEID DLTGESLTQK DMTIIHVERI TKLQELVFQK
     YKEKMKTFYL STVSEVDNRK NLFKYFSVLS DEELLNLCVD LNLVDPNNTD DSTLNRPLLM
     EMMVCHHEKQ PSQLDRINEM SLYPSEEILW NEKMVPVGYF KNATCLALPK LGLQFLTLYD
     YLLRNFTLFR LESTYEIRLD IEDAIFRMQP WKHEIEPNTL VCGGWARMAL PIMHFVVIEV
     GRPRVGEKAP SVVRADVQLM LDVRQDVRTE WESAPNRRGI FVTIFTFFPI VDLRKHDVGF
     LLTIRPTALP GTLYCPSEPF LPQIPVVYVR GCEIEGMLGV DGNVIEEYAP PEAKLGFTNN
     VRTFRVLLDC QQYRLDMMQH EKGGEDVYQT FNVFVRRKPK ENNFKAVLGT IRQLMNSDCV
     VPSWFNDLLL GYGDPSVAHY SKMEKQFTVL NFDDTFLSVE HVKESFPDEY EIIANENDLK
     PPYRISVDET DKKVCIFQEK DESRGPYPFC RRRFNAVLFT KAQVDGIYSG MQHGLTVIVG
     PPGTGKTDVA AQIINNIYHG WPSERTLVVA HSNQALNYLF QKITERDVDE RHLLRLGHGE
     EFLGMGKDFS REGRVNHILE KRLQLLGQVE RLQKSIQVVG GDVAYSCETA LYFYEYQLQP
     RWFEFQRKSK QLRRVGEIFP FGAFFDDLDG PLFLADDGDE EEGELNYEQN MQIAHSCWNY
     IRNIFDQLAE FRAFESLRTR YDRVEYLLTS QAKVIAMTCT HAALRRKEFV DMYFHYDNLI
     VEEAAQILEI ETFIPFLLQP TVQGKNRLRR LVLIGDHYQL PPVVKSPALR RYSRMEQSMF
     TRLVRLGVRT IHLDKQGRAR QQLAALYSWR YDNLGNLPHV LANEEFLTAN AGFAHPFQLV
     DVDDFNGDGE TTPVAYFYQN LAEAEYAVAI FMYMRIVGYP AEKITILTTY NGQKHLIRDV
     LRKRCASNIF FGKPAKVTTV DKYQGEQNDY IILSLVRTEA VGHIRDVRRL VVAFSRGRLG
     LYVLARVSLF ENCFELTPAF RMFENRPRKL IIIPNETWPT KRLVNEPSPY SELTIDGMSQ
     MVNFVYDLYV SNFNVIRTEQ MKQHGESLTP TESCLPVLLD NEKDEVKPPE EENQQAEDSA
     IVFEVLDE
//