ID A0A0V0U628_9BILA Unreviewed; 5180 AA.
AC A0A0V0U628;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Retinal-specific ATP-binding cassette transporter {ECO:0000313|EMBL:KRX46692.1};
GN Name=Abca4 {ECO:0000313|EMBL:KRX46692.1};
GN ORFNames=T05_13155 {ECO:0000313|EMBL:KRX46692.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX46692.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX46692.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX46692.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX46692.1}.
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DR EMBL; JYDJ01000053; KRX46692.1; -; Genomic_DNA.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 4.
DR CDD; cd10014; TFIIA_gamma_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 2.30.18.10; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009088; TFIIA_b-brl.
DR InterPro; IPR015871; TFIIA_gsu_C.
DR PANTHER; PTHR19229:SF185; ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 3.
DR Pfam; PF00005; ABC_tran; 4.
DR Pfam; PF02751; TFIIA_gamma_C; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF50784; Transcription factor IIA (TFIIA), beta-barrel domain; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:KRX46692.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1296..1315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1592..1618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1638..1665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1677..1699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1706..1726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2840..2860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2881..2904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2916..2934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2941..2962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2974..2995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3016..3040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3812..3833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3853..3880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3892..3917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3923..3943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4008..4030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4473..4493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4505..4525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4531..4550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 838..1067
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1847..2085
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 3095..3328
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 4070..4306
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 5082..5108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5143..5167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5082..5097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5180 AA; 589944 MW; D38A5D328B310AE0 CRC64;
MILGTFGHAL VEHLLHGCHT FLHLSCTVAP CALVLHTASR SAASIPCSLC HRHNNPKNTN
TSAFVIYANI LDLNYPTFRQ LLLESSSILL VTELLWPLIF FLFLLLIRHS TVLMNRKLCQ
ALDGFHCFNP TFVHYPTNVI NNFIANIRLA FYNESVLRET LSFFDDVEDV VNKFSMLDSF
QGNFNGVNIA DFFTKGDDMM IDLILHDKGL EYDAIESLLN STLTRKSNSN VSESNLEMEK
LLQNFMCKKF PIEIFYRRNV MNRTAYIEIT NLILGNMTGL KINATEANSL YITTSKFFEK
MKSSELANNA LALWKHFLLH SATNSSLAKN STFKNLDLAS HMFCGGTLSE QLREQMIRTD
PRYIDTMRQS GVQLGDDPNI VLPWNLYNQT VICDHFEHEI IEDKCWLWLQ QYNLPHDFTM
QLFTLFRGYI LVAPSSPIVK RVMSDMSDQL VLIDYFCQSF LHWYDNMEKY AENFARFFIT
FHETANIFQN YTYGEAILKL FYKLSENNWQ NETITYMREH LSHLHNMIKC FRQDRFVLMK
SENEVERAAS CLTKTYQYFL GIVFDELDNN STALPKFTKY KIRMASYLVD STSQIMDSLW
NPRPRDRPFI DLKYLYFGFS FVQDIVDRII ISFHTNKTAP RVGIFIKSIE RSFPMFMTLS
WMFSVAITLK NMVEEKQYRL KDQANLAAAV GALIYFALFL PYPSVLPYLK NMTFLQQCSL
CLIAQVAFGW GCSFIALYEE GMQGLQWSTL FLPLTTDHRL SFGFVLIMLI FDGILYLIFT
WYIENVFPGA YGIPKPWLFF FQQKYWSRQK STLPVACDGI NSETVTVIHE SSCNPVGVAV
RHLTKVYDNK KALSNLSVNF YDSEITSVLG PNGAGKTTMM SIICGLFPST SGSVIIYGKD
ILSNISEIRQ SLGFCPQHNI LFDNLTVEEH LWFYAKLKGM PTAELNEEIE NFLLNTKLRY
KRKEISKNLS GGMKRKLSIS IAFIAGSKTV VLDEPTTGVD PYSRRSIWDM LLKFKKGRTI
ILSTHYFDEA EILGDRIAII SEGSLKCSGS AMFLKTYYGS GYYLTLIKNS LGKLHLEKAQ
PEELIKFVSN YIPNAKLVRC SAQEVKFMLP SVNLLELKSL VTALDSELKN IGCSSYGLSE
SSLEEIFRHE ITESVKANNT HKKQKLTMPS FKYLRERIRS MLSSISKSTT TYNAQSKYFK
AGNTEKIAVY IDECNDSFDR RQRQQLKSDV KRTSKSEIAC HENDMIKNSS PALLVRRHFS
ENYPITFYES IWRCILLQAA ALFRKRALNF FRDWRTILSV ILLPILLITL ALYLMSLRFS
SSYFEKEYQP LILDSDLYGT SNYFDSKQQF LYPYITQMER HGPGNICMNR FSLENSVSHC
SPDISESDIS WNISKLSYEN SSKCFCGKDN TYICSENAYS FQPPVLKSPF GSIVNMSTLN
ITEWLTMTEK TYRKKRYGGF STGLPSVITV ENSYTDLNKT VQLLKERILK FFQSTNINMT
ILQNSGIHIP TFDTGVFINL MEDMIPQYNV KVWFNNQGWA AFPAYFSAFS NAYLRGNLPS
DSDSDEYGIT VTNHPIKGYQ KSSLTQEKKN SVAAELAMCV AILLAFCSVT AGFCLPVVED
QNSDSKHLQF ISGMRPWVYW FVNFAFDMSV YIFTVTLTVI ILIAFNEEPY VATSYAILFM
FTIFIAFGLG MLPIVYLLSQ LFKSPSLAFV TVLIIGFFIG SITNVLTTAF EILGVEDENL
HNLSMHMKNA FVIFPQYNLA RALSDIKITY HFYSSANRIL DRHYFADLIS WQVSGKALFI
TVVEGFVSFM ELQFSESNKL SSLEDDDGNV TAEQRRALKG ACADNALKVV NLSKVYHTCS
SIARKSQVVV NDLNFEVLQG ECFGLLGHNG AGKTTTFKMI TGKCSISQGC VYFAKTHAPR
SNWKSITDIG YCPQFDALDE RLTGREILQF YADIRSMCRK CKDAAVLYYI WRLGLNSHAD
RLIRTYSGGL KRRLSTAISL IGNPRIILLD EPTASMDPES RRLIWDVILE RINLGQSVLL
TSNSMEECEI LCNRVGIMSN GSFKCLDAIQ ELKEKYGKGY VIAISLKAGY EWQMDSMIQE
LKDRLKVAVL TEKHVNILAS DHTKVSDIIS CISALKEIFC IDGCALNQTS LDDVFVSLVE
QYDECKDDNV LYLQLLFVDG LYSSELCTVF YLHGVCQTVE NVAVEKLLNS FSSQSVYEPK
ALSSAGIFSM FQSYFCTLPN KCLNYTTDDW DLGPVSRKLP INDFISGFRK SMKKQIAFNK
TIEILDYSKL LIDQFWSFSE YQNDFESVEL MKLYNLTGAS GALRLLAITL GIENVNVSRH
FFEDLLKSYS ETFAVDKQEV VETFNKKSFK LLCEESKAER YFLVNSNKTS TTPRDVHKAL
CLLSGFADTK STPNLDMFLI DHILNNLTGY EIGFQKFLYL ANVLESYVQI AKKFSFIPAG
VDLVEQFLNY NAPTNLKNDS VMKRLDFLSH IFCGAELTGL DEILKSQKKL EQLREDMVRT
DPRNIDARRE QLFSRKNENG LPWNLKNSTV CSRYKHSDIG TREDKCWLWL QSYSLPHEFA
AQLYTLFRGY IFVSPRSPVV EKIVEKMKSR LDVVAAFKDI LLSTFENLEI YRTKFESSKL
SKASKNFARL MKNINSIVNL FENDTRQDEK LKLIDFFSNE LWRNASLENF NSSFFQTYNI
LKCFLCDRFV IVDSEKDLEQ DGSCLTKTFH FFAGIVFPQL NSSSLTLPKY TKYKIRMSHY
LVDKTAQISD KIWNPRPRDR PFLDLRYLYF GFSFMQDYID SIILSMHVNK SAARFGIYAQ
QFPSNCHRID TFIKAIERSM PMFMTLSWMF SVALILKNIV HEKQFRLKEF MKIMGLYNSA
HWLAWFLQSF IMLLISSLMI VLVYGNVLKY TDMGCLLVFF VAYAFAIIPQ CFLMSTMFNQ
ANVAAGLGTL LYFALFLPYP AMLPYAEYMT NAHLFFSCLI PQIAFGWGCS ILASFEEAKI
GLKWSTFTHS LSAMSYLNFF AMISMLLFDG ALFFVLTWYI ENVYPGTHGI PKPWHFFLMP
SYWTGCKTDK ENKSKVVYSA LESKTQENCN LEVGVSVRNL TKIYGSGNKS KCSLNNLSVD
FYANQITAVL GPNGAGKTTM MSIMCGLFPP TSGNVLVYNQ DIMSNLAEVR RSVGFCPQHN
VLFDTLTVEE HLQFYASLKR LTGTEQKLQI QDLLKQTKLM NKRNAYSKHL SGGMKRKLSI
AIAFLGSSKT VILDEPTAGV DPYSRRSIWD LLLKCKKDRT IILSTHFFDE AELLGDRIAI
ICAGKLKCCG SPVFLKQLYK SGCNLNLALS QADLKNNGNT TATLVDFVCG FVPDAKLVKC
SPQEIQFTFP TVDLLELKSL ITELDAKLAN LKCSSYGLAE GGIEKIFLQE VALSKEDEQL
PSQQQGFSAQ KSLSGKEEKL ASKLSSDKTP EKKQSPHAVN GLNLEKENFF EDRFYHSSLP
DSKKSAVDGF LKKRMLNLVR DWRACVAVQH CYVFKIILPV FLVALALYLL SLRFSEVLFN
LDYRPITVDE TVYGRNTYMF YSSVGNEHNS VNKYFQAIIE DIMKHGMGNR LPHFRLSNVK
QNRTFSEPVT EMKKENLTKC FCDEDNTYFC PKNAYPFKPP ERITSFGENL VDMTNLSIAN
WILMTEKKYR MKRYGGISLV TLPHEVTEIS ATKTGKDWDR LYTHLMEFFE SMGFNNTSLP
VDGTPIPEWN MTRLETVLNQ VTPKYNIKIW FNNQGWVALP VYTNIFFNAH LRAALPEAEN
PDDYGIEVIN HPIRNPLEVS VSDGSSVAAE MALSVSILIA FCSVTAGTCL FTVEDRSSEC
KHLQFVSGMR RWLYWIINFI FDLIIFMAAV GLLLVILHFF NETPYIGSAH AILATLAHLM
AFGIGIIPIV YCISQLFKSS TLAYVSVMVA GFFIGSITNV LTTSFEILGA EDEYLNYLSK
MLKAYFVIFP QYNLARGFTD IKIMYHFYVS SGKPMGYEYY VDLLEWDILG KFIFAFISEG
VLAFFILLIL EYHYELIEFW KSICINISIH KDCDESLEEV YLGNASSVAL KVTDLTKIYG
NWFQNTNKQF TAVNKLCFEV HRGECFGLLG HNGAGKTTTF KMITRRCSVT SGSVLFPAKK
RDSMKYQSEI GYCPQFDALD PRLTARETLL FYAKIKGIQK EFQNPVVNYF IHRLKIEAYA
DRLVGKYSGG IKRRLSTAIA LIGNPYIILL DEPTAGMDAE SRRFLWDVIL ERVHCGHSVL
FTSNSMEECE VLCNRVGIMA HGKFKCLDTI QGLKEKTMNK ALSTKVRSKI QFRAGKLCTY
RFCDNVWTFV MEQIEFRDSH EIAKMSGFVD QSGWYGAGGE WSGYEMPSDA QKDYSHKNYL
YSNKLNSGNY YGTNFAYDQL NEMEQNNYLD EPPLLEELGI NFHHIWQKTM SVLNPFKEAE
PAVINDCDLA GPVVFALLFG SALLFHGKVQ FGYIYGVGVV GCLGMFTLLN LMTPYGISLI
STVSIVGYCL LPMVLLSTVA AIFSFKDTVG LAISAFAVLW CSASASKLFV TALVMNNQWM
LVAYPCFLLY DACLQSSQCN GMALCFRRQC ISAEVLHGQT KMCRRDIECR RQLPAHERLI
VGCKNGVCAK LITVPHTSKC VSRNQCPGQS ICFRRHCIPA VPRNYSCQRN AQCHPTERCI
GGLCFGLLDV PLSELAGKVR EYCESMINKI DAENVFTNVL VGLENYFSVN FCCTDDDSLY
GIMEEDDECS TSTSNSVKAV TTVKKISERV ARFLEENIVC SFSAFRKKAS NLPCSAFSKA
QQYKLQGFFY LAVLLGKTKE DKVADYFQAL TLLEGSKALN KILENFVFPM LSKYLPRHLT
CLYMSLNVSL PSKLKKYRKF VESDSEDDLT RIGEDTVFSK LKILERISQE EKIPARRTDK
TKSTLPFEKM CNPLKKSCSL LEIPHHRFVK VAAGQEHSVD FTKYRMKSPE QSSFQSLYSV
YRGLSPTTVK LSKELEEMLS SSGSFCDDSL LKTPEKHTEM LKRLSKSLSS PNFATISSDA
NEPWSPETRK SLIMGINRVK STPNFSNYSC IFSDVSESSM PAVQLEDDSS SDCMSPLPAK
RSKTLSDQDA DKVLAPATPL FKQRLPSLFR RAKSRLEKFG VQTVLETPPD KTNSEEDGKL
SSTAASNASR NRVITRLNFN
//
