ID A0A0V0U8L0_9BILA Unreviewed; 706 AA.
AC A0A0V0U8L0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Tubulin alpha-3 chain {ECO:0000313|EMBL:KRX47530.1};
GN Name=TUB1 {ECO:0000313|EMBL:KRX47530.1};
GN ORFNames=T05_3023 {ECO:0000313|EMBL:KRX47530.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX47530.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX47530.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX47530.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000256|ARBA:ARBA00011747}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX47530.1}.
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DR EMBL; JYDJ01000041; KRX47530.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0U8L0; -.
DR STRING; 144512.A0A0V0U8L0; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02186; alpha_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002452; Alpha_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF417; TUBULIN ALPHA-4 CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01162; ALPHATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048}.
FT DOMAIN 287..502
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 504..649
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
SQ SEQUENCE 706 AA; 79459 MW; 0F0BE5A422B7C310 CRC64;
MLELTMFRTV KLFCYFINIF TLQEFIYKIA VSANPYLLSN EDIYSPWKMW PKSIFLPGSY
PFMHRTDTNY ILPKPFLTKF SNGIATGSSR IQFLRGNLKI PNLRQGAIWD FNGQLRAGPT
LAHFNHDNEV QPRNPLNLSP KAKSILENDP AFHELSNQGL MKGVLQSPFW PNRCNSPYCS
PDLASFDSST VYQGQKNFYY DGRIEFPVFT GKHGQGYRFN QGGDFYAGKH PTVVTVGHHR
EVISIHVGQA GVQIGNACWE LYCLEHGIQP DGQMPTDRSL GVADDSFTTF FSETGTGRHV
PRAIFVDLEP SVIEITQMKI PPTYVFSEID INEVRTGTYR QLFHPEQLIN GKEDAANNYA
RGHYTIGKEI IDLVLDRIRR LADNCTGLQG FLIFHSFGGG TGSGFTSLLM ERLSVDYGKK
SKLEFAIYPA PQVSTAVVEP YNSILTTHTT LEHSDCAFMV DNEAIYDICR RNLDIERPTY
TNLNRLIGQI VSSITASLRF DGALNVDLTE FQTNLVPYPR IHFPLVTYAP VISAEKAYHE
QLTVGEITNQ CFDPANQMVK CDPRHGKYMA VCLLYRGDVV PKDVNAAIAA IKTKRTIQFV
DWCPTGFKVG INYQPPTVVP GGDLAKVPRA VCMLSNTTAI AEAWARLDHK FDLMYAKRAF
VHWYVGEGME EGEFSEARED LAALEKDYEE VGVDTVDGNG KEADEY
//
