ID A0A0V0U8X8_9BILA Unreviewed; 574 AA.
AC A0A0V0U8X8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=TWiK family of potassium channels protein 7 {ECO:0000313|EMBL:KRX47235.1};
GN Name=twk-7 {ECO:0000313|EMBL:KRX47235.1};
GN ORFNames=T05_11085 {ECO:0000313|EMBL:KRX47235.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX47235.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX47235.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX47235.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX47235.1}.
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DR EMBL; JYDJ01000046; KRX47235.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0U8X8; -.
DR STRING; 144512.A0A0V0U8X8; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF333; TWIK FAMILY OF POTASSIUM CHANNELS PROTEIN 7; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01095; TASKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:KRX47235.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 251..309
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 375..445
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 40..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 66319 MW; 36A35502825B3FB4 CRC64;
MAADRTVPAE PVPDYPSVLR LFPLPIPWIG QHHMCDNRWN SRRQEERRQR RIRTKKKHEY
NKSNRKANDI ANPEELIEFI DEDDEPMYKT TDPADVKVPT TIDDSTTSPS ELAIKFPSTS
NYQDEEDDDD DDDDVISSST DNWRTKMRVI LPHIGLIFIT VVYTMIGAAI FHRIELPHER
LMKRYSLNEI EASRLVLIRQ IWNLAKNHTD NEQVEFETLA ARSFDNFTDL LFTSFHKHYL
TAKEIAENRT IDEWSFSAAV FFAVTVVTTI GFGNPAPVTL TGRAVCICFA LFGIPLTLVT
IADIGKFFSE YLVWQYERYL ELKFKLRERF ARWKKRLTGR GKEHSTSFLV CEQCKQKRML
ELEGGTVPAS VVIVILVGYT ALGGFLFCST EMWNYFEAFY FSFITMTTIG FGDLVPKRGT
NMAGILLYVI LGLVITTMCI DLVGVQYIRK IHYFGRKIQD ARTALAIVGG KVIYVGEWYN
QMLARYRNGL TGEQLKNGFI LHDVYLTKHQ VPFIPKDIRR IRYIDWSSES VSSVDSAYEN
RSCKYCHCQR CPKVITTTTS ASSPKAKRRR RFFL
//
