ID A0A0V0UEZ0_9BILA Unreviewed; 1829 AA.
AC A0A0V0UEZ0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein crumbs {ECO:0008006|Google:ProtNLM};
GN Name=crb {ECO:0000313|EMBL:KRX50084.1};
GN ORFNames=T05_7119 {ECO:0000313|EMBL:KRX50084.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX50084.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX50084.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX50084.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX50084.1}.
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DR EMBL; JYDJ01000009; KRX50084.1; -; Genomic_DNA.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 12.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 22.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 8.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 3.
DR SMART; SM00181; EGF; 26.
DR SMART; SM00179; EGF_CA; 17.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 21.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 8.
DR PROSITE; PS00022; EGF_1; 21.
DR PROSITE; PS01186; EGF_2; 16.
DR PROSITE; PS50026; EGF_3; 25.
DR PROSITE; PS01187; EGF_CA; 7.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1768..1792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..109
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 111..153
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 187..227
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 231..267
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 270..306
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 308..344
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 347..383
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 404..442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 443..482
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 495..529
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 531..571
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 573..616
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 619..792
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 797..833
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 839..1058
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1054..1090
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1118..1305
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1307..1344
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1346..1382
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1384..1420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1423..1464
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1466..1504
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1506..1542
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1544..1582
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1584..1621
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1623..1660
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1662..1698
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1699..1745
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 77..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 99..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 143..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 217..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 257..266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 296..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 334..343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 373..382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 432..441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 472..481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 519..528
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 542..559
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 561..570
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 765..792
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 823..832
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1080..1089
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1334..1343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1372..1381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1410..1419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1454..1463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1475..1492
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1494..1503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1532..1541
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1572..1581
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1611..1620
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1688..1697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1735..1744
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1829 AA; 200132 MW; 483BCDD8BE115D70 CRC64;
MTLRGHLVSE ACPTHCPSVF HPIDQQLTTT VRVLHWNRTP EVAVVVGQQP TVARISFAYR
ESSRAELKGI VLPPSECVHH CLNDASCRAA NGTILKCICP NGFEGSRCEI RSGKCPADYC
VNGGTCHVIS QDSYGEVIFG CHCLDNFSGD YCEIESKCET ACTGDSVCRA GSCVCRPGSE
GTPGKCVPKD CNLDPCLNNG TCVVIDNDDD RTATCNCQHG YSGLLCQLDF VTVDCPPNTC
PDGHLCEKFQ DEIRCICPKG FAGISCNVPL GSDCSIDLCM NGGTCVKGNP VSSCRCLAQF
DGPFCQFDVN ECLTIRPCGR GNCTNTHGSY TCNCEPGWTG HNCVEKIQHY CQNGTCQNDG
LCVEQEEGFR CVCSDRYAGK FCEIDSAAAF GKKSTSSPLA DDPEKTSCSS SGKCFNGGVC
KVEAGKGSRC ACPKGYGGKW CEIELSCNNI PCLNNGTCIK MPGNAVGVGC KCLPDYYGSF
CEFFAPKLAI RLKPTSNFCF YNPCQNDGLC DESTQSCVCG PGFQGLLCEQ DLDECDHRGA
YCPVQFSVDC VNQHGDYHCE CKPGYAAKNC SIRLNACDDY RCGDRQICTV TWDSRAEKQR
AQCECAPGYT SMPSCSQSTV ASFSGQSMMV DITSNNHTAT ETYQLELEFR TTLESGFLVF
GDDLFNSNIF QVLLLDGQIQ ALWSGKRLRI EQKVNDGSWN RLSLNWHANS MLLRLERTTT
GDVHLKRLPS EGGLLASTVA STKFGGTPLE KQHPYYPDVG NFVGCMRDVI VNGKLLVPEN
MGASAVNVSW TCPRRQNHEP CDETQCPARS HCVDVWNKGR CVCDRPYLMP NCEKSLPEVT
FGFGRNNSFA MVDIARAYSI GLHDRLDLSM LIRSTALNGV ICYIGTAIDD QNFKFDEHQA
GCCFIGLELK DGYPVLVSSW NSTSPTIITS ANRLNDGRVH LIEIKYRPHV LKFFVDSQPA
LVNWFDNGQT ANPLSPEQLI IGTHPILVTN RTIMDPFTAV EPFSTFTSFK GTIQDVRIND
DIVELTPVAD VVPSMLGKVN GRVSRHSLLL GTQSDDLCAS RPCANEAHCT VTFNDYKCQC
KPDWVGKNCS IAHPCLGEPC PVDWQCLVKP HTYEHVCLNS ITFSEQSRAL FQALNAQDAD
HVSFSIRTRT KHGPVVSIRG TAPTNEMQIF LKDGRVLVSR LVAGEKPILL DSLRPIADAQ
WHHVRVGLWP NLTMELDQDV MMIAGSAVPL PAETVWHFGS VTDQDRSAER SPQQVGTDES
FVGCLRAITF GTDAYVPFFD DDRGSSHGFQ GVFRKISSDH LTQGCRSSVQ CGLTDICENG
GTCSDEWNLA TCTCPPGFSG LKCENDVDEC EYGWCKHGST CRNLIGDFAC DCLPGWTGKL
CEIDVDDCAF HPCMNGGTCV DGENTFHCLC TTNFTGPTCE QRHYFNCSSG PCENGAQCED
VSLVWNAKPF VCHCGAGYTG ERCELEIDYC ATVNCLNNGT CKTSVDRDTY ICNCQNGYTG
KHCEHEIDEC ASSPCQNGGT CSDLMNNFTC TCAPGWIGAT CEIDVDECSN DHDLCQNGAQ
CINMPGSFYC QCPPYVSGDL CEEMIDFCDS NPCHNVGGVC HSFVGGYNCT CFPGFKGEQC
EENIDDCINR PCKNNGKCYD QINGFSCDCT GTGYEGLFCE LDVNECETLD FCNGGNCTNL
PGSFKCSCLK GDSGDRCENL NPCDSNDTHY CQNGGICKEP YVDYQRGMVL HRCDCVGPYT
GQFCEIKMQE AKSEVEAIPS QTDGWVEFVV GPVVGFILIL VLLGFTLLVI VAKKKNATRG
TYSPSRQESD NARLTLHRMI KPPPEERLI
//
