ID A0A0V0UHM3_9BILA Unreviewed; 15151 AA.
AC A0A0V0UHM3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Flap endonuclease 1 {ECO:0000256|HAMAP-Rule:MF_03140};
DE Short=FEN-1 {ECO:0000256|HAMAP-Rule:MF_03140};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_03140};
DE AltName: Full=Flap structure-specific endonuclease 1 {ECO:0000256|HAMAP-Rule:MF_03140};
GN Name=sls {ECO:0000313|EMBL:KRX50593.1};
GN ORFNames=T05_14727 {ECO:0000313|EMBL:KRX50593.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX50593.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX50593.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX50593.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Structure-specific nuclease with 5'-flap endonuclease and 5'-
CC 3' exonuclease activities involved in DNA replication and repair.
CC During DNA replication, cleaves the 5'-overhanging flap structure that
CC is generated by displacement synthesis when DNA polymerase encounters
CC the 5'-end of a downstream Okazaki fragment. It enters the flap from
CC the 5'-end and then tracks to cleave the flap base, leaving a nick for
CC ligation. Also involved in the long patch base excision repair (LP-BER)
CC pathway, by cleaving within the apurinic/apyrimidinic (AP) site-
CC terminated flap. Acts as a genome stabilization factor that prevents
CC flaps from equilibrating into structures that lead to duplications and
CC deletions. Also possesses 5'-3' exonuclease activity on nicked or
CC gapped double-stranded DNA, and exhibits RNase H activity. Also
CC involved in replication and repair of rDNA and in repairing
CC mitochondrial DNA. {ECO:0000256|HAMAP-Rule:MF_03140}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_03140};
CC Note=Binds 2 magnesium ions per subunit. They probably participate in
CC the reaction catalyzed by the enzyme. May bind an additional third
CC magnesium ion after substrate binding. {ECO:0000256|HAMAP-
CC Rule:MF_03140};
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03140}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03140}.
CC Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03140}. Note=Resides mostly in
CC the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
CC {ECO:0000256|HAMAP-Rule:MF_03140}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. FEN1
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_03140}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX50593.1}.
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DR EMBL; JYDJ01000005; KRX50593.1; -; Genomic_DNA.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008409; F:5'-3' exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0043137; P:DNA replication, removal of RNA primer; IEA:UniProtKB-UniRule.
DR CDD; cd00063; FN3; 6.
DR CDD; cd09907; H3TH_FEN1-Euk; 1.
DR CDD; cd00096; Ig; 6.
DR CDD; cd09867; PIN_FEN1; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 63.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR HAMAP; MF_00614; Fen; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR024969; EIF3F/CSN6-like_C.
DR InterPro; IPR023426; Flap_endonuc.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR47633:SF7; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 52.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00060; FN3; 7.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00409; IG; 54.
DR SMART; SM00408; IGc2; 49.
DR SMART; SM00406; IGv; 7.
DR SMART; SM00232; JAB_MPN; 1.
DR SMART; SM00220; S_TKc; 2.
DR SMART; SM00219; TyrKc; 2.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 58.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 50.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00841; XPG_1; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_03140};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_03140};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_03140};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_03140};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_03140}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_03140};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_03140};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_03140}; Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03140};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_03140};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03140};
KW Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_03140};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 13612..13639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 14023..14042
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..157
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 191..281
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 366..508
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 518..609
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 665..747
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 772..862
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 897..987
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1034..1124
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1167..1257
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1384..1475
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1516..1608
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1649..1740
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1781..1872
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1913..2004
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2045..2135
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2176..2267
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2308..2401
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2441..2532
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2706..2796
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2837..2928
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2969..3060
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3096..3194
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3239..3330
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3376..3467
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3482..3569
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3618..3708
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3753..3840
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4108..4202
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4207..4295
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4306..4394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4429..4534
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4971..5060
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7659..7747
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 10389..10484
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 10492..10587
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 10593..10692
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 10698..10795
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 10801..10889
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 10911..10987
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 10992..11085
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 11135..11390
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 11462..11538
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11555..11644
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11747..11834
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11845..11934
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 11961..12051
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12105..12201
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 12200..12290
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12304..12396
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12406..12488
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12622..12711
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12722..12811
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 12975..13064
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13077..13168
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13181..13270
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13281..13371
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 13385..13473
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 14109..14428
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 14483..14617
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 3220..3241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3972..3993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4037..4064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 15131..15151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4044..4064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 11164
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 14143
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 15151 AA; 1701110 MW; 679B9572A3F7B502 CRC64;
MAGKYRNGFF SQFVLSGQLG SVDFFADHLY YFLKQKLQHF SFANIVHVYF KLLQLSKTLI
KTIVETNGRD RERETWQPLQ NKRSVVGQQV ILECQLEGQP DPVIKWLKDG QNVTNCPDYQ
IFQEGNKFKL IIPSVQMADA GRFDCQAINA AGSKSSSCIL IVAPPPSPGE RQFMTAPSPR
PPPTPVGPAA PYVVKELKHQ MLKIGSSARF ECRITAFPAA EIAWLKNGKP ITNTSKYKID
NDPDSGICSL TIAMMFAEDV GQYSCSARNA HGQAVTSAEI LYKDKYNEWL REEQIKITQE
KKRSMMEELD NAVQQPRKQK GTFYTPHSQR LLEQLYTEEK VETDTKINES EASVENVPFQ
GVPQPPQVIR PLQPVSIIEG QKAELTCQIK GNPTPKVRWM KNGVPVQNSQ RLQTSYNGAV
ASLIIKITFA EDAGMYTLVA ENQFGRTNQS ANIQILTQNS VNGVVHRGNN QNDLNTLIIY
MATVEDSGTY TCVATNESGQ AQCSCELTVK AHSQGSAAHF TEKFNSLIVH PGDSVELKCS
AVGQPRPTYH WYKDDEELIH GQCPYDIVNM PNGTRLRINN VRLDDSGCFQ CNAVNMYGTA
VHKAPVKVQM KSSSQQITPF PRDSTSDQAL IASATPELAT IRHRQRAAGL SNAAWFVEAA
SAEPPKIIGL SADHLSLLEG QLAHVEVRFQ PENDQNLKVV WFKDDLPLEQ TGRASFDIDY
VQLSDGGLYK CLVVNQKGKA EATFTISVTE LPEVDFNESH NYRENVSSKV RPNFVHELKN
VESVEGRSVR FEAKLVPTRD PNLQVDWFFN GQPLRLGNRV RMLQEFGLVS LCISAVSVTD
AGVYTCRAKN LIGVSESSAT LIVKTYEIGN YKNADNTRGY IADVDIADVE EDSCKMPCFE
VNLRGGTVKE GGRILLDGKV SPARDPYMRI DWFKDGKPLK LANRIKMQYD FGFVSLCINP
TYHEDSGVYV CKASNRVGVA ESSAEICCAG DDSIELRTQH ADSLQRIQRI EGQEVHIGPY
IEDRPEEVMS IEKPRFTKHL SNAEISEGQT AHFDGRLLPF NDPKMSVNWF RNGLPLPNGH
RFRLVNDFGY VCLDVLYAYP EDSGIYTVVA QNELGEAASE AELHVIGHKS IYLESQHPDG
MNRIQKLERQ TEIPLHEGIE RISEHSPVLK NQLRDLTLRE GSNLHLEVRV EPVNDPTMQV
EWFVNGRPLL TGSRSQMTFD FGYVALDLKS LIAEDSGEYI VLIRNQHGEV TSRCIVAVEA
KDSVLTEVQN VESFERIKAL ETEKPRQIQE SESLPQSAPV FTKVLSPASI TLPEGSSLHL
EGEIRPISDS SMKISWLRNG QPIPIGKQAV IYGTQHPNSY EQILRIEAPK QNREEVDEEQ
PDAPYFVKEL PNEIAITEGQ SVHLECIAEP KNDANRSVVW YFNGQPLKMG HRFQFSHDFG
HLVLNVLYAY PEDSGDYMCI IRNQNGEARS VCKLQCQGKK SMVLETCHPD ALRQIEELER
PTPVQEQLDK HCTEKPEFLN TFPEQTEPLL EGQAFHVKSF IRPTDDPNLT VEWFHNDKPL
LASHRFQTKH DINFVSLDIL QVYPEDSGLY TCRAKNKNGT AENSVFIACN SRKSVITEAS
QPESWERIRQ MEAVLPQTAE EMPVEKVKPS FTVPLGGETD VKEGQSVHLA CQVSPTDDAD
LKIDWLFNDQ PLKMGSRFHT CNDFGFVSLE IDPVFPEDSG VYTCRALNEK GEAFTSLKID
CKPIKSVDFD SHHIQSLQKI KELEESQPDR PPSPEIQYHP PTFTQVLQNV DTINEGESVR
LECRLQPAFD PSLKVTWLRN GQSLPLGSRF RPTHDFDYVA LEILTVYPED SGIYQCKAQS
AHGEAITSCS LKCIPSESLI LETKNENSWN KIQEIERPAI VESIAETPFI TPPSFVEPIS
GMQTVNEGAP VHFECRVQPS NDPNLSVQWF HNDQPLMNGH RFRTGHDFGF VTMDILYSFP
EDTGQWTCRV ANSLGAEDCH ANLVVVPKQS IYSAACQPKS LAKIQEIEAV PQKQDAEQEL
VPVAPSLLQP FENTERFEGQ PVHFECRALP VNDPKMIIEW LHNGLPIKEG NRFRKTFDFG
YVSLDIAYVF PDDSGVYACR ARNDLGEAIV QAELTVLSKG SVMMDTTRPE SWHKIQELET
VAPALAEAEP AAAVQPRFTQ ELNSCTDMIE GQPAHFEGKI EPRNDSSLKV QWFHDGKPLP
ASSRVSFQND FGLVTLDIAY CFPEDKGIYE CRVSNAAGTT KSTCELQCKA RSAILADTMH
EGSLEKIRII EAPKDVPPSQ DVACNERPVF TQPLRNIDDV PEGEAAVFEC RLRPVNDPNL
HVEWYFNDEP LKISNRIMPT QDFGYITLKL ASTSTFDTGV YLCRAWNLLG EAVTTASLQV
QGKENILRDS QHPESYRKVQ IIENLEKFPR QEIAEIAYEK PAFEQVMENL ENLNEGTLAR
LTCRVRPADD PNLKTEWFFN GKPLAHSSRI HLMHEFGYIA LEIDPIHVED SGVYTCKAFN
ASGEAVTSAS VKVLGSESLL LQTEHPVSWK KIQNLEAKPL VEVEEQETIQ EKPRIVQPLQ
NFSDVPEGSA VHLEALYEPA KDNTLVADWL RNGDLIIASQ LVKTKCELGH ATLDIDNAYA
EQHSGVYTLR LRNREGEVMT SCSVKVLGKS NVLNDTQHES SWRQIQELEK PKEAEGTPAG
ISYGSPVFTE HLNNVEVNEG ESASFRCQYE PVNDPNLKLE WLLNGKPLEA SSKFSVNSEF
GYVLMNIAYV FPEDSGVYTC KAINAAGEVS TSGTLKCFEK ANLILESQRS GAMAKIVELE
APKSLPTEDD TVPMLAPQFL TPLSDITDIF EGQAAHFETR VEPANDPNLV ITWYHNDIPV
EATSRMKQIN DFGFVLFDIS SVDMRDNGQW TCVAKNKVGQ AQCSANIQCS PKAGIIIDSQ
QPQSLPRILE LEAVKATPEV LPAVPPEAPK FITCFPKLDP LTEGDTVHLE AQLVPVEDAT
MKVEWFHDNK PLLLGHRLKT IYDFGFCVLD IICITAEDSG EYKCVATNAS GSDCISTTVT
CQAKGSLLLD PISQTKAQAV KDLEDSLQRI PEKDVPEVLS MAPVFTHPLQ NQSQLVDGDS
VHLEAQLIPV NDPDMKVEWF LNGNPLKHGS RVKCLNDFGF VILEIAPVYA EDSGEYHCKA
TNSQGEAVTS ATLVCQPRER IIREMQLPKE LASAQKKIEE LEAPKQKLDT TEEPSYPAPT
ITPLTETELE VNEGQVAHYE FKLEPLDDPK MTVEWLYNGK PLSHGSRLKA LYDFGFVVLE
LAPAEPHDSG EYTCRAVNAA GEASAKVSLN VKMNRGVSYD WMLSQADARN KITQLEDYLH
RPPEEASLLE QDFGQPVFVQ ELSDLGDINE GEAVQIDCRI QPVGDPTMRI EWWHNGHLIP
YSSRIQTHHN FGYVALLIQH AIPEDTGEYI CKAINSKGES SSKCILTCRS STSFPPPKFV
SPLLAIISDV NEGDSVHMEC RVIPINDPQL EIQWLFNGKP LSTAHRFKTL SDFGFVSLEI
LYANPEDTGT YTCRAWNKAG EDSTACTVSV KKRPSLIFER QAPPVSSLDI ARRISQYTTK
PCVLSAENFY QDRKCQKPQF VSQLENTAVN EGDFAKLECQ LTPINDPNIR IEWYKNNAPV
ILGQRFMSIS DFGYVALVLL YALPVDTGEY TCVATNKFGS DKSVATIACA PQKRVITDSQ
MPQGKSVASI SRNDEMLHWA DSTDAQNRVN QAPAFTIAPT HIQAVEGQPA RFSCAVTGMP
QPKVSWFVND KQAVNGSNYK LGYDGMHYLT ILKVRPQHAG EVHCVAKNSE GEVRTTTTLD
VFRVQDFRSH SLKPAKREDD MDIARREEQW KQESLGKLKD AFEKAPKADL QKLMRIETDK
QQPSPLESKE LIDKFKKKKQ DDFYDKIYLT EQSKVVPPSQ FTETVTLRAT PMLEKELPKE
QKIEYKLRPA PRTKATSDMQ TQPAWHRSSR RHLTDEEENA LYHRLPEQQK EPEIFARDLV
TLKSVKPNIA METADESHMQ LEEHKLASTP SNKSQQTWTT NQDIPSQQVT LKPSFVPRAV
ASQESGTFDV ESRKDAAAML KRPSKQPPSI IRPLQPCQVE AGRRVELSCE FAGSKPLTIV
WLKDGKRISS SFEFQTLETE NTSKLVISKA KHNHAGEYTV VIKNVAGEVK SSAGIVVGEK
ISKGFSPKFI QEIADASVIQ GATIRFDARL AGKPIPQVVW LKDDKQIIDD AHFVITADQD
LYSLIITEAF PQDAGMYECL ARNVHGEAKC HATLTVTKPT AFKPSPQVAK NVQSASLPQL
VVNKGDVATL KIPVSAEQGL SVKWYKDNKL ISPDNRISTM CKDGIVSLII KNSDIHDSGN
YKAEITSSKG TSVAVFTMLC KDSHTFYRWA SHSFPRKTPK PMPLGFTSPH SSDRISAAES
ISYDDIGSAL YFETELKDIT SEAGTPVTFA CKLVGDAERI VWRKDGQIME EGDEFVQQYN
SHNGWCKLTI SEVFPEDQGI ISCQAINKSN ESVTSCFFTV QDFKSNTKSK SAPVFPSLEM
LPPCITKHLE TITTPPNTTV CLFVEFHSTA AAEVQWFYEQ KALPNSPKCI QRRGTNWAQL
QLISPQEGCY SVKVTNDFGT ATSIAYITVQ EQWKSLEHST ESINISEMID VEAYSSETYE
KGIASMHGPY FVQKLPDKLA ILNRKLHLTA TVDATPEANF AWYFENIELK CSTSCYITSW
KNQSTIVLEN AKHGTYKVVA SNALGSCEST VAVYEDESES NRMSKFSPQF IKKLHNMSVE
AGEELKLVVE VLSEPVASFK WFMDNNNVSP STVMSADNIS ELRLIPEEGK THTFVVKAEN
EVGVAVNSGV VIVKPCRISK RISDDISWHS NDVYFEETEM MHLEMSGNFP YQATHKEYLD
GEMDLPYPLA STKSTEKVIS DQKQSEYLHH EHTLMAEALF TAQPSHTDLA PKIILPLENK
TASSTENITL SCKIYSAVAY AILWYHENHR LIDSEETQIV VKDDGSQLII LKRPSEADAG
LYTCLAVNNY GTASTSSRLT IMKPALPFTY QQEMRDLYST STEAIEICQE TDVVQQKKVT
IESTMPQLQS SGALRAVSQT EFTANANLSA NDFEVSTVIQ HSSKEYASAD ISHSVMKETN
EEMEYRAEIT KPPYDDTLNL YSMSAASTKP SFTDVPVFGM ERTIHMEIFE EIKITESRQE
ATHQTETVNI EFEFCTSPSE EVYISLDAEC FSCGSRILLK GSMPECKEIT FEQRNIEEMT
ILYEETTSIR YYSSTVTSHE EELPSASDLY IDKLAGPLSL YSEESIDGNF SFKLIVVSEC
AHTVPLCREL SFVVAVSYAE HEWNTVVRII QEETHQYEEE CLTSYFTAAT KPALMPQVDY
VSPVIATKAI QLEVTDAKEI HEKILSDHSI TLHMDVCLEA MNNASAYTLL TTSDRFVCTA
TIHTEGEQKA EEITKTVSEI THEEVLCVIE TQIRSEISES EQTIYLEILC PSSVHYCNLL
VKCGEILQTM ANVYLESKTV TLLIDNISKV REECNEQYNA PELVLERLPQ QQLIQRAASS
TEAAVHKSIN ACRMTEKFTT ITLEKKNSEE IEEVLKISTK PLEEVHVHKM VNSFQLAVDK
EEHLEETCSF QVPRRILQTV EIIEDECLEE ITVHQQRTVS TMLDMLVQLE IPSQQFLCDI
EVQLSLTASC EANILKGKEE TVKTEQSIKW VVEECAQESF VEIVLEEAKH IELRVTEQHL
DIQINCHDIN NSVAVLLMFF EWCEATFNVQ EVLPLAKVYE QQETLTTSST SVESILISKQ
TKYEYVETTI TGDVLLHRPS DYFELIVCID GVNVEAIFCK ASLVENAINF QQVALQRREC
FDVSLPVKTV IEQSVKVAEI QEIEKVVCEF EHIVFDSFQT TVDHSMEANL IVDISKPSCA
FHSSIIVMLC DSSHATLSVI NRQEESTSSI TTPYNESMFE ANLRLIISTD DSISSTTSEM
EQGIISSMEV SSIAEEAVVL SDSSVHKMEA THIVSDEGKT VAIDFHNPVS AAFSTACIEE
ISIFSVEETN VVCQDWQCSY KFACPSKVSK TLVIVESDMC DSAKFTTADK TVEFSYMELT
DICDLAITIL NGMEFSSPTM VLRKSATDKT ALFHHLTQSS EIKVLIDVEA NNSTKLLTAF
EFDTIASELQ NRSSWSTVCI IENYENAESF LAVEMARIKK QSIHEVSEEI SVVIEQPHCE
EKACEITFES KRLSSASFNF KWKDDLLYDV TLKNHLTLSE AIACVISCMD IEAAKIYFYE
VISTKMLLNN STAENSVITL QYCHPLTQLL KTHLTHADIS SLNEVLPILK TEITAPEMVK
EDVESNLLCS TTAVTELIDV TEVSASVHTR AADAEVSKDT PTVTLKETYS ENQQDSDVTV
ELLCSSKSCS AEAIICPYVW ESCMKQQDLH SINFTAVANL KSESLRTECL ISPFLNETTS
VSVRIQTGRL NQSSVTVNLS KENMKDHVHA VVTSLDFQQL KPFKACCPQK HLTSVDFYAS
KKFEMYNTLA TTIIPETCLL DYNTTLIVTK KNEIVTEETM TESTVNSFEL PDLRNAAETQ
FTSLEHTAID TFLEKMPFYG ECGATIECSD TQSGVMQHGS HVCVVEREFE CKDTPMLTAC
LIEADSDKCY TQYLHDSFKK SFYDFLLTHV ESKEECEVVL QMDTCLEEER ILYGNVVENV
SVDSFFQTVA KPHSTTELRD LHAVSSCISR FKSEESPVVT HQWIQAFSTE AMCTIEESVS
DIISANVTLR TKDVEYAECS TECEFRSAVE MEQTFGCIEN AENACLSMVY DIKKMLPASH
YVSHDISIRP ELQLQEVNVQ EITEQAEFAH KKLLDASVVI QIVPSGTILQ YVVDCAYEEN
SISFQASNII SECEMAKCLE ANQQSVITFV FSCDTSNITT HYRASSVTDT TEAAIPEYSH
ETWEFASADV CSFEKYISLS PCSSAFAEYT RAGQAYINIL SAWESASITE NITMESLSKC
DGCQHVISHL LKETYGSCHN VLSKAFVNTS SASDESQLII NFLKQTADAK DFKIQYEECS
LRTDYLGESS AVIECTVQEV QQESVFKLLK LSSMLNEKHL DLTLESDQHF RSCQCTVHSL
VMETASLAIT LEETCADFGV SPSVADELIT KSHSTHPFSI IEKQEKFTVV ATDIYLDSSV
NSSLVEYTTT ALQRMSDATV HEIVNVSNDF PCKRENTFDE DEILHKYVLQ ETIFQSAEKT
DLSVFMEKTE ESEQCTFTRW SSVVACTVPI YYSVSKMAEE IPIPALPSMK ETTVEVLLEK
PLSVLECHFN FTDFPSVISY LGLNRQLITC FNVKPEAFEK ISTSWADVGL LAQDMFLTDN
SKEETYSIEN KQRSESEIHY STDEEKCLQA SYEEVYNNVT LERTSVEALE IPMKSEEIIK
CFSEHVYCEI TFVLKEDNKS TESYMSSCNF ESESAFISLI EKDLTCTAKA CNLAENQNIL
TSELLEKFEN HVTTNYIDEV AQFQHDDELQ DAITLDAKDN VIAGLQLTTT QKFENVMLEV
SWLHQLEFGD LQSIIEQPDR IVTDIHIQPI SPKRTQEVLE VIETTDEEKF QSISCSSNFT
QENEFKNEIV CSEANKEHAM LYLHLIDTPA RQDVFGQAPE FTLHLCNTEI AEGSHVRLKC
IVSGQPTPDI QWFVDGDQLA SSEDFNIIYE DGVSMLNIKE VFPEDEGEYS CEAVNQFGTA
RTAAYLAVIP VEKQASATDK ECTECYGKEF ANDEWPVETV TMSQECLSML KPEASCEADV
AVRITDLEQL KCLSPISDGI AEIVASHLAE TNEVFVYGST KCMEDTPFTY ISEKAVESVA
EHTLNMRENF AEVNTLVSLS LDANQNISLQ AVLKQPRVAS LVFCLTSLTK PILPTLVNDQ
ETARKYGLTL HSISDDSIAL NVGNSESFAD SSDFESSSQD AFVSIDVDLV HMGARCCGIF
TLLSRPTESS SLTLTECELK ELKVLQSLLT LPLSREDCFP LIERYIRECK GYISMEATLV
RRDSELNISA CEIHLYRQFQ NVRLSLVTVH KHLEQTDNKA DLSEEFPCNE VARNFLDTQY
NHATCEMKLF NLNSEAFVDF NSVNANAEFK DTESMLVSLD FEQIQSQPHV LAFCIDNQML
SLSKNFVSRK GCYSDVDIQN IGGDLETFTN IPHSSADYSC LDEISCSVLI EKASESISCS
NTYASADMLN ISKCSLFIPF LKVDDSVVGV DVQISKDCKR TGDDIMSLPE TETNQLPCEV
AVAMIISEKI AKHVSSTAAF LSEPSFFHEM RTASLYPVTV STTFISENVN NCETEKVFYS
PSITRPGTFT VLSNTISAKY EDIEVLKLDE QHEIQTELYD MDLSTSRTNM CLCQRNALIR
KCNAENKCVC HLPSVCSFDE NFFHVEFKAE MIANNCVEMC LAQFLVEKCQ LKLLENRQST
ICEVDCLEDS EYLHAVLQYF NFESISFQLS HTVKNTLNKK FSRDVITGHC STTLPVKHTE
NYDIALTVLS FNANALSCCE VHENITVQKS ESSNSLSVSP DSILFKFTAV SDYSNVEQCL
TVQNNLENDI SFHSEFSQIE GELVVTSNPH DSYTCILTVA PFYNCEMWRS VLVCSCCYDA
LVETDEEANI TFSYNKTTIE CCTSISFANS YVEIYCPEDV ADIRVKLGCT AQQPYQQSLN
ESQCSLTVLI EKDESESREF IDFPEKVHSV TNRSFFARQT FLEETVDVQF RSSANNCFAD
HTYHEAGDKS KCTVIKVENK ADEDFQLFAQ GIKQDFKAET VEHIKQYFVP HGSDTKLMEK
LSSSENLVQW FINGSPLDSA IYSIETDAGY IRPVAELIVE DSTSPDLDNA VIITEMPFQC
VQQNLDAELH GPEQNANTDI NLSEDQHFYA SKTYEIDMLE NIMNLTATFT SEIVNDIAKA
EKITDVKRQE IVAHTDLTAD MALNLMRAEE IELSIAESSN PENACLEVLN LFVARQHSDE
TMLATNTLNL KTPEQSAALC CSEEENITSL STTNMNFLFT LGPLSCSKTA FNSEMKKMLH
CANIILSNVH MFASYDATEN LTAECCIAES DTCDTQFSSV DCGKMLLTST LDQKDNISYT
ACVHQRLKEE TSSTQSNFVD CNLIHEKSAD HKEAVASFSE QCSDTISSSV TAATITKKIV
SIDDIPIIAV GSEIMESLRK PKRKEKRKIS EITANESFNW KNDLKVERIC MEISVENCSS
SVKAESVQAL IEADHKEETE SICCLHQPHF FVESAFLLSQ KQQSQEKQTL NILFSANFAV
SESKILLQEL CTASEEAYIS IKEHYDVHLT CKQTEETVSS TLSRTVTADE VDFKNKKEVI
EESAIIEEPT KSSCTAFDVH ESLHDSGDAS FHFTLKYHQS AHIRRASDFS ELTYTINLPN
LERKQYEEIQ FQDVNYLKSP EQLFKETITT EEQVENAILE HSVDDVALKV ESQSISAKEG
ASAEIEIKDF YKGTTVMNIT ATVMKKPISE EVTKILEINQ MAENSHSCGQ LAESVTNETR
VKITCKKPQE IMAVQALFAE VTTLFSYEFH VGQRICKPLQ ETSRLLSAVD TTQRYFQEIS
AEVECRATDD NTSSTERGID LSVHSMTSSA VSKTFADIEV VLEQFPALEI TYNLENIRET
LLLNVCDQYF KLELPLKQLD AFMSILLPYT LKITQHSAKC ILGSAINFVE ADVRKKSECS
HCMKECSCAP FSGCVICISR ANVSLSVIVD KPSTSQSEAM IPIEQKHKLE YLDCTYASEF
TAPIQSEDEA HFISTAKTSQ QLQHIKSTEN VVNVNANING LEANAEVYHS VRADEMEFTS
EGFFSLKSKD QVDAEEASTL STLEVYENFK REDDHSDITF QKLIIHEIPP LDETLSFSVV
AEECCLKHAD LSECCQAVIA ENKVCLSHFQ FKHVKDHIHS CSCDIYFSKK SEVAPCTVQL
GKLLLQCTMS ESSCFLYIPN GSSLAAETEL LDAQAVKIPA LEILHTECVC DKVSSWKGNI
ELPVKEKICV SDFLLKDYIN SDFDITVRID SSHASYTIKN TCIVASDMEK ITVSSICTCF
EKGSIEEMTE EIFAESLLGI RKYRHRHLKD FTEAACYCIA LTKHQESLSC ISSYFTSVRE
SCFADIKHLK LVENYLTKLK PTTEEATEYD YVNISTAEKV DVSTIMASST FLEKETSALC
DMTFEKKADI SSSNEFVIHT KSTADAVFSV EDNAFYHVSA ELSLSHKIEM DEIYEQEDAS
YCTCSIDASL EKLSSKDYAY AFVDLSNYGK RVFTFKHFRD IIEASSVSSS LQRHPPEKPE
LFVENLFATS SDVIYTSEKV NFQLLLEAKT SITTIFTRQL LNDVCSITLP QMNQFEELVT
SVKIAPVIPT AHLTVTRLSD HSVNLEWNYS SETTEDNIDG YDVLLKGETD DEWSVVAILD
RSQTHCILED LTNSYTYKFA IRIRKEDAQS ELLETESEVY VQSRAVSLPK RPKGPLKVNV
KTMSSIYVEW NPAEAEDFMN ISSYVVLIRE SQRTTWLEVA TVGPEETRCH VSDLNSGSEY
HVRVIAVNSL GISEPLETEH PILMERIPTL LTPPSPCKPP LNVLSVHNTS VTLQWNPPED
DGGSPITGYV ISRRHLAQKH WEEVERLPEF VLEYTVSNLK QNARYLFRVN AVNSIGISEG
TQTTEPVNIR KWKDKPGAPG KPTVKELNAD FIVLQWSPPE AANNATVTNY IVERRDEGCV
RKNWLVVSRG INPNVELLVE RLIPGNTYTF RVSAENDSGI GPASEISDNI TLPLKTVGIA
PNFLTLLEDT SVFENEDITF NVQFCGQPAP RIKWYKNGRE ICSDEKHRIS TAKNHSSFQL
LKASENDEGE IAIEAENCHG TVTQSAQLKL KAVAKIIRNE ITQNELFRGI GETAHVSFEV
KGSPLPTVTW EKDHQQLTVS NRVSVQSDGP SQSLEISQCT YEDSGIYTLR AANIYGEDSI
DVKIKITGAP SSPGKPVVLE CDEESITISW TPPLYNGEAE ITLYYVESLR VGNDWTVFGT
TKQEKLTASF TVEETPVKFR VKAKNVHGIS EPSEATIWTR MLKQTEDITV DLTFQQYKEK
QQRQMSEFDS LVLSVPPTSL HKTDDQLPGN FYDKYTLCEE LGRGAYGVVY RAIENATGLT
FAAKIIQTRP GIPKDNVLHE IDIMSQLNHP SLLTLHEAFD MNSEMILVLE FVSGGELFDQ
LLEGKENLPE KEVREYIRQI LHGIEHMHQK QIVHLDLKPE NILLSTSFSK DIKIIDFGLA
SKLKENKSVQ LLFGTPEFCA PEVVNHQSAS FCTDMWSVGV IAYCMLSGIS PFAGDTDEET
LANVSVADWN FDDSIWTQVS DTAKDFVSKL MTKNKNNRMT VEEALQHPWI TEEPAEVTEI
AAPVERPVPQ LKLKKDSITK RRWSDELLPI GKLAKHSAIL RQASMDGVFE RELHLEVPDK
IPNIIAKLEN TVAEAGDLVV KLKCTVDVEI TTSKKYKIIH DNTNAELNIS NISEDDEAVY
SCIAENKFGY AETAARLAVK KVDKEDSLKR SDSVPTFFSC PYDQNVMVGE SFDLLVHVGG
KPFPQLKWYK NGKQINDTSE KYQIQRFDDK ECITIQSFQK DDAGLWQCIA INDLGTCEVK
FRLTLKYPEE FCPPKIIENL KDISVENGQS FQLQYKNNTE IHHGEHYKMY FDDKNSTYAL
SVNPAYVEDS GIFKCVITNI IGSDETSCKV TVEEYKYGKE LTTSGSPPSF RIPLEDRTAV
EGEDHTFVCL VDSIPQAEIT WLKDNEPIGT VTNQKVENGI CSLVLRNINQ NDAGVFSCVA
SNVYGTCRTD CNFSVHSEVE NAHYPEFLQI LTDVTVEENS QIALECLVEG IPFPKITWYK
NDCEIEMTNR MMYTEDISGH CVLRILNANE KDAGIYLCRA KNTAGETTTQ CVVTVVDVKC
KRSINIPDES ELESEKRIVE PLHIVQPLQD VFATAGKSIL MECEISSSPR ASVQWFKNGQ
FITENANMRL VFDGRKATLR IIEASIDEHQ GEYICRATAL DSVVETRGSV IFKDEGEVQH
SDLRFTSIPE QAAPIVYSEV EDIQNVLKRP VADDVELTWS DKETLIDSFY ITEVEKTSLT
LCWSEKGQHH EAALYKIFVR PQHASKWTEV GITKDSAFHV INLQEDTEYE FLLTAKRQKE
WEKPVQLSVP ADKSKIRTLP KLHCLSDLNV KLNVGEKLKI VCQVDGNVTS VITCYKGNTK
IQDDDRIIVQ HQNDGTILLM IESVQENDCG SYTIYAENEY GFSYQTVTVT VTSANAISEQ
RETPNIPCIL HPLVNQTLRT GKTATLTCRV RCIPPGKIRW YKNGQKIKSG NRYQLLASKH
QAYRLMIHNV DEEDTGLYQM AVENEYGRAS TECMLTVKGG VQHKAPFVEK SLEDVRTNVG
SKVILKCKIT GQPNPSIIWL KDGQKLKSSR DIQLNFDDNN CMLIIHSATV ENTGLYACSA
TNLVGTVSTE CRLLVEGPPD NILSKYKAPV FTLTPELRLA ALENENIHLQ FETYSDLPVR
FTCLKNKLPA DAGRLNTHIY EGTHMSWTIN NAMISDSGEY TCIAENDVGS SEFTFKIWIT
NLSQCSDEEM QELKEKKTPR APYFTQNLVD VQSQTGDDVA LKCCFDGYPT PTITWQFGDN
TTLKYNYECQ ILQQGHECKL HFPSVQQKHS GIYRCILENE LGKAESECFL SVGSSSLYPI
PPQFIRCLYD IWTPLDNEIT LTCQTIGIPN PDITWYFNGQ QLLESSNVRL FFDANNVCGL
TIVRVSGPDL GQYVCEARNE YGIAKTAATI HAGEPHTGKP PIFLKGLQDQ TVHAGSRITM
GVLVKGEHAY KLSKKYEETV IITGFPDGVL SLDVPTEQTE GGDSFAERSM KTRRKIPKRL
TLKEYQGEAP EFIKGLKDVE LEEGGRAAVS GRTCKRKLPK TQDEQSPSLC TSSKVKTVED
IRAIVHRRNE CPCEPKFIIR PRERKEIEEG KSLRLKAALS ASPTAQVSWN KDGVMLESGS
KYGIYNDGDF YYIEVHRVNA DDSGFYNCIA SNTHGVASAS SHVVILPGSP EKAVRPPTFT
EVLPGVVDAS VGECVSVECS FEGKPIPHVT WTKNGNTLTP SSRVQLTYDG ESASLTVNKV
EYSDAGRYCC KAVNCAGEAR STTKIKVKSA SELDATVAPM PKFLHHLVDQ TVGDGDQVTF
TLQLVDAWEP IKITWFHDKC EIQDSPAFSY VRDGDKCILI IQDAFPEDSG VYMCRAENAY
GQAISACTLT VIGKEQDPEI PSFTEIPDTA TALIGQSVTI SVNLKGYPEP VVSWSKDNAA
LSSGEKYQIY NVGNSHHMTV LNCGWEDAGT YKILATNNVG SCEGTVLMDV SKDFTTALEP
GHSHPLITVA PSGAEVAIGD PLQLNCSFTG QPCPVVVWYF NGKRVEPSDL VSVIHTENAS
FLTVKSCQEE HFGEVSVSIR NQYGEDLASA HIKHRKGSDI VDFICLSWAK LINRIDRQKL
YCSFAKNSFE FQSPAEMKKI QLLEPLVKGI KFHLTLIYGT KRCLKMKLCC SESTRLFFHD
KKEAVIKITT DVPSVSWLTV RLAHERCLTT PTVVMISRSM RSNCCRLYRT EFGLSIVRIA
CLLSVMLLLV CVVFHIPYFH IQAYDQAQKE QQACERNCEI HDTLKAYENC LRRCYSYVDY
NLVPTRFTGS TSNKTYPKPP TNITVNFNVY RENHSKHLRA TINWDAEREN IVSRSENCNY
LLDDSRTGYY LIFTAKSNSC EQKFPGYYTQ NIPANARSWD LPTQTMSLYP LVLDFGCKYR
VEMRSEPYPY GDTNYASIVT VQIPACVDNY CSCPQARVSQ PDILTLRPFW DPESNSIKAQ
LVWRFKWPKE IKDESIEFRV RLAQVIRRAG VAALSTFRFL TIVGEPGKQL FEVILGNLKN
QSEYQVQVFA INKHVCKSKE EIAEFTVNVN SSKNNTDEPA VLENNESLLL PLTTSSPDET
ETSVIVLSTT EKADIDKNTT TNVASDNGNI LQTFEQQQQQ ERYLTATLPT LAVIVLVLIS
VYCQMRFRRA VKSAETKEKF LRIPDKSSFD IDRYLELSME TNILYTEKEI SDAQRRGAAD
KFEMSYERLT FKGVIGQGAF GLVYAGTAES IINHPGPLVV AIKQLKADAT ETERNEFSLE
ISTMKLIGDH PNVVQMFGCV TLQQPNCMIM EYVPYGDLLQ YLKNVRKQYE KQLSTMASTG
CQASAINLHT VDINVVADCH CGYCLPAVEN DDTELEYRQN SNESNIPNLS YSLNPVELQN
FAMQVANGMA HLESLNITHR DLAARNVLVG YGKCLKISDF GLSRSGVYVK TTSGRVPLRW
LSIEAMRDHM YSSKSDVWAY GVVLWEICTL GGFPYRHVAD KELLRYLDSN HRLEKPHSCT
ESIYKLMLLC WSKEPENRPP FSQIQKMLTE MTRNNMIEAL LYDLEYTMSD EESEESVTVD
EEEERKPIVV RKHEKVDLPI TKVIVHPLVL LSVIDHFNRV YKITKSPRVV GILLGTVSGK
TVDVTNCFAV PFEQDYTALP PVWFLDHEYL ESMHMMFGKV NAREKIVGWY HSGPHLYSTD
IAINSVLKSF VMHPVLCVVS VKKHGIPADA YIEVEEVQDD GSVPLRTFEL LSCCIQSEEA
EAVGVEHLLR DIKDQSAGTL AQMTTRRVVG LRGFVEMLRC IKCYLEEVSG GSMPVNNNIL
YHLQEIFYIL PSLQASLSES YLSETTDELM GLFLGSLSRA VYGLHNLIDN LVKYREAEKE
WDKKEYTKRC EMARQLKKQS TNEPAQNKVI ADFSPDAITE RTMNSFFGRT IAIDASMSLY
QFLIAIRQDG SQLSAESGET TSHLIGMFYR TIRMVENGIK PVYVFDGKPP VLKSDELDKR
TERRTEAEEK YADAVQAGDS EAINKFSRRL TKVSKEHVDE CKRLLELMGI PYIEAPCEAE
AQCAALVKAK KVFAAATEDM DTLTFGSDIM LRYLTFSEAK KMPIKEFRFD DVLHGLNMTH
EEFVDFCILL GCDYCPTIKG VGPKKAYDLI KQYRNLETIV EKLDKKKYPI PENWQYKAVR
KLFLEPEVID CNTIELTWKD PDEQGLITFL VNEKNFGHNR VVNGCAKLLS ARRSSTQGRI
DSFFTVLVTK KKRPADEGSS KATAKKGKGK K
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