ID A0A0V0UMZ7_9BILA Unreviewed; 934 AA.
AC A0A0V0UMZ7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Uridine 5'-monophosphate synthase {ECO:0000256|ARBA:ARBA00015047};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN ORFNames=T09_11723 {ECO:0000313|EMBL:KRX52751.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX52751.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX52751.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX52751.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the OMP decarboxylase
CC family. {ECO:0000256|ARBA:ARBA00009769}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the purine/pyrimidine
CC phosphoribosyltransferase family. {ECO:0000256|ARBA:ARBA00006221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX52751.1}.
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DR EMBL; JYDN01000228; KRX52751.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0UMZ7; -.
DR UniPathway; UPA00070; UER00119.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 2.
DR Gene3D; 3.40.50.2020; -; 2.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014732; OMPdecase.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR00336; pyrE; 1.
DR NCBIfam; TIGR01740; pyrF; 1.
DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00215; OMPdecase; 2.
DR Pfam; PF00156; Pribosyltran; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF53271; PRTase-like; 2.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 2.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681}.
FT DOMAIN 703..915
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 934 AA; 105008 MW; 3A79850009DC30CD CRC64;
MGATGLGEHR ITVHLSSCHL LFTTTLLKMD PRYETFLTDL FHLGAIQFGE FMLKSKHTSP
IYVDMRRLLS HPTLLNTVED LMYDYAKELE YDVICGVPYG AIPLTSALSV KRSIPMIMQR
KDAKAYGTKK IVEGLYKPGD KCLIIEDVIT FGSSIAETAR VLRAQGLIVT DALVILDRCQ
GASRNLENLG ITKWSLFCLP DVLLLYEGRG LISNADCQRI SSYLFNVTDK IAPSALGNGL
QEGAKVDKTG VLSVKAASNT ASLSHNLAKH LWQIALDKKS NLCVACKSSD PKEIIAVAEL
AQKIGKFICM LIIRSDLICK VPLVDFISEL KTCAKSKNFM IMDDRKFCDV SSIVEMQLTG
GEWSIAKWVD FVTVLPFSGR GVFSAIRKVS AENKVACFSI LSLHAKDSLI PKEFSEQSMK
TAEKDIDVIA GVVCSKPPVL DSRFLYMTSA DESDQALLRF EDFDEMQFLE VEYLEMNHGI
QYADIYKVWA FIFIVLLGSI NITAIFKFET VVMRSLYETP IFVDFQLAVS YPEIMNEIEE
LVHSCLLSNL KFHSICGVPE GGLPLASIIS VKRNIPLLLY HKTKETTVTG KVIDGVWKKS
DNCLIVDDVL MFGHSLADAA DVLRQHELEV TDAIVLLDRC QGPENFLKSN DIRRHYDLAG
KFVDQCTIDE RMEPLFFSPD RLSMILHPKA RKLWEIALSK HSNLCFACDL CSPREILRLV
EAVAVNICSL KLHADLIAIK EMPDFFSRLK RLAQSKKFML INDGNYCDDS DVVVELMLNS
ATKPASWADF VTVQCLNGSS VFEAIKRVNS DYSVACLPVV EMSTSGNFFT EEYKKRALSL
AQQYRQIVAG FICQKRPIND PSFLYISPGV HYKRRLDDQN WRTPDKAVRF NRDDIVVVGR
GITKEKYSRV WAYTYQQISW DAFIIMNNAA ANVE
//