ID A0A0V0UQH6_9BILA Unreviewed; 1810 AA.
AC A0A0V0UQH6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 03-MAY-2023, entry version 22.
DE SubName: Full=Telomere length regulation protein TEL2-like protein {ECO:0000313|EMBL:KRX53545.1};
GN ORFNames=T09_2782 {ECO:0000313|EMBL:KRX53545.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX53545.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX53545.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX53545.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TEL2 family.
CC {ECO:0000256|ARBA:ARBA00006133}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX53545.1}.
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DR EMBL; JYDN01000198; KRX53545.1; -; Genomic_DNA.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.8.1120; Histone RNA hairpin-binding protein RNA-binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.25.40.720; Telomere length regulation protein 2, C-terminal domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029344; SLBP_RNA_bind.
DR InterPro; IPR038294; SLBP_RNA_bind_sf.
DR InterPro; IPR038528; TEL2_C_sf.
DR InterPro; IPR019337; Telomere_length_regulation_dom.
DR PANTHER; PTHR15830; TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER; 1.
DR PANTHER; PTHR15830:SF10; TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF15247; SLBP_RNA_bind; 1.
DR Pfam; PF10193; Telomere_reg-2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054681}.
FT DOMAIN 141..317
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 347..442
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 467..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1810 AA; 207022 MW; 677B3D4FF9CA2DBE CRC64;
MKRSMSIITV VYHIHKCRAV ITLVRWQRLD EKCPDRETID RIDLVEFNLI SRTIRAKKYL
QSIFRSIKAI VSDLCSPSRI QIVASGKTHI KRFVGFDSSL CKTRTMLKLR FKQPKHAWVL
VMEKMSEKCD GGLPEPSTET QLAKIYDEFV TSERHYLEHL DLVIRYFADP LLCSKILTQR
EVANIFGDLR SIRLVNQVLY DRLMAGLEIA EAFGDLIHFM KLYSAYGRNY SASQQLLLQL
LEKNKHFRQF CEMQECLPVL KGLKLAALLI TPIQRIPRYK LLLEQILKLL DNSSRQHLQI
SKLVQQIGAL AETVDSCIEE FENSAKIIAV QNMLDGCAPK LVMPGRKLLK EGLLNKMSSS
NSGFRHRMFW LFTDIILYAK PAMKKKNRYQ CCCILPLRHC MIERILGRSM FRLICKDEVL
LLHAEQYSVM DEWVVAIENA IRYLLECRKS LRKESSNSFP MHRQALKLHR SRSSFTEKLS
SRKTQIPNDD PKPTKKRRSF LLSLLSKLGG RWSSRNRRQS GDDSLAEVET NNSRMTNSVS
LFSTGSRLPL DNIAEETSIL GRRPKEPPPK NHRLTLVLCK KSRMKMSPIP LNWLLKSNRY
DYSRRLESSS LSTSGIKSSV FELFGECDDY VLDFGEKSWA DIMEEEELYE KEKLSRMNTQ
QNEANVIAPF VEESTSETIV PEHEVAAVDF SQLHSTYAQQ MLSKSEPSHE EPSTFARRNR
RMRRPVAPGP RASKQAEADA NEELKQGSQW TRARQPHLLN EENTLEAGDV ESDKRKEETL
PVVVKPVEEA PKKRVGPPLR YPLPATWREP TNGWEEDQAV LKRRQKDLDK GYNSEAYKKY
IAAVPKSKRE KGIHPRTPNK YLKFSRRSWD SQVRLWRKML HVAVGEEYNS DASFVSSSSC
SDASSVVSEN EVTSLRRLSE NEESVEVGRK VDPVNESIPT NQQDDETLTE SVHLICQSLE
SKKFASYGAS HSRKAMSECK STTTTLLKRL LSASSRLELR SCLLDIGNYV VENQNFGSFF
RVGEVLLQAL KPSTFNMLLP VEQDELFYSI FLRANPADVV LLLSKPPDRI SPFVVPKFVL
IVERFCQHKL DQLFTSMANA DDGHRPCDRS MQGQLCQALF AIPDRMVGLL KPREAKKRLT
VYWNNFCSAY VRSLGQIDDQ LTGAVVNKSE LEMSFHGALL GKACLTGRQR RLLEALLPFA
LRRARNARRR GRRAWFDQLF RACPADAVKQ LFTDLILLLK SASDLHTLVD DFGVVDDQAR
FVLSRSLLFT SHFDTATVPR LVIGYLKLVG GEQEKVLLQE IFLLSLQNWS FKSSIVNTTV
QQQRYVAQTL LLTAKELVRR HWMEELENQA APFVLDGMYN HLGGLSSNVQ QLGMVVGEAL
VSMLKMPVED VKFNYEEDDF VASLRAMLED ELPLSEQESA EDILSDFTVL SVDSTDEMIP
IQINLRDSDD DEDEDNSETM TDHYQLEEDE QLMRRRKGQS SQLSYIEDCL EQLLCVENDD
YDCFEMALLS LEKVLFKERS TPGVGELAGH AAKVLLHLEN KFAQQLHDQL RVKCLVGCVI
SDPLNVAAYL CQEFHSRALT VGMRVEVLRV LCTAAELLSR DANNNTKQKQ QHVENSLLKS
GALAPEQWVR DGWRAVLQQR IEAKTVRRQK YDYQSADRCR VNRFASIAAG IFDMLIDRRH
TVHSTALREP LVLGVFVHTL ATLLLAAGHS AQLRSMAKLT ITVGWPEHCN HEEPLVRAGL
LFAFLAVLSR LPVELLFADL GEQNLRERVD WLERVRTGDL DPNCRQLAEL TLNTWNQAIL
RMADQIFTCN
//
