ID A0A0V0UXH7_9BILA Unreviewed; 1381 AA.
AC A0A0V0UXH7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Metabotropic glutamate receptor 5 {ECO:0000313|EMBL:KRX55974.1};
GN ORFNames=T09_4028 {ECO:0000313|EMBL:KRX55974.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX55974.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX55974.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX55974.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX55974.1}.
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DR EMBL; JYDN01000133; KRX55974.1; -; Genomic_DNA.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15285; 7tmC_mGluR_group1; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF134; G_PROTEIN_RECEP_F3_4 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRX55974.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1381
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006870497"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 608..869
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 879..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1348..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1018
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1152
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1381 AA; 153937 MW; 26520AB6F0871FE0 CRC64;
MLMVVVSIWL AVSLTAVLAP KSASHTRVAR IPGDVEIGAL FPIHRKIAGT ERCGEIWEQY
GIQRTEIALK TVDAINDDNA LLANLKLGIS VRDDCWTERI AMEQTIIMVR DAVGGPNAHS
KQQRCCCCPE DKHCQANDGD EPTSNLVAVI GPGSSDVSIA VQNLLQVFHI PQVGYSATTK
ALSDKTEFKY YMRMVPSDSW QAKAIVDIVK YFHWSYVAVV YTDGNYGEKG FEELQKNFDK
EDNLCIGVAE KIKSLAPAAD YDALIRLLMT HRPQITVAIC FCEGDTIKRI FQATKRVRES
LQPDGNDTYQ GLQWIGSESW SDRKDVVAGV EDVAAGGFSF RIYSPRMTQF DSYYFNLTPK
NNFRNPWFVD FWEEKFHCSY TESTRNLYPK ICTGNENVSY GYKPDPKLSQ VTNAIYTVAY
ALDAMYNDLC KGSKEKGLCD AMTPVDGTVL FQYMLKTMFR DPSGQEIYFD ANGDPPARYD
ILNYQGKVAS YVTAGEWDHS FHSDKFNHQS GIYYKSKLRI DRDKILWHNH MSGLTYTPTA
RCSYDCKVGE IKKIQTLKCC WICVPCYENE YLLNEYACKR CPLGYWPLEN RTACYKLEVE
YMRWSDAEAV VCVVFACVGI IATLFTIVIF ILHNSTPVVK ATTRELSYII LVGLLLCYMT
TFFIISPPNM VSCIIRRIVP GTAFSMIYGA LFTKTNRIAR ILAASKKITT KRRRFLSISA
QVTITGLLVL VELITIVVFL IFEPPKADFD YSLPKRVLLV CRTSGLTFFA PFGFDLFLVG
MCTLYAVKTR NLPENFNEAK FIGFTMYTTC VIWLAFIAIY FGSAKKDTTM CICFSLSATV
ALILLYFPKM YVILLRPEKN ARSYFKTTTT IRCHFGSNAK SSSSDGGGGG GGGSSGSRIS
SVQGSQRKKR WAAVRHRTQI LHSPAGRYVA RNDSHSSYSA QSTPDPAARG RRHSGRFAAG
DELTSRDEQQ ADESACKPDE CSSDSQRLLR AVDEMPSVKE ETDDDGGDDD DDDDDEPTTS
SEHPVSSRKF LDRTGSLWRR FDPFQQNPQL NRGWRSLRVP AGRNDGEAAP TLLLKIAAER
LDTVRHFIDV DPPASGSTGT TAAVAERQPR SNVSTISGRA SFARRKGTGH VWFSSSVGET
DDDEEEDGDD DHDKMDTDRR GTTEETLLHS HKDRLVVCRN SQPESGEKQT AFSNGGFPVI
EFDEVDMRRT VVLGRSTNKT TAGEDPLPHR RPWGRKVRSN SDTVAWLLQR QSQLSNFTWN
LTRSESEQLL GPVRGNSLKT LFTRKPFAKQ QTKSMPCLRF DATVDTAGTA KQQYSSPGSS
SLVTTALTGF SRAGSMSGSL LLSPIEELSN SSSSGSAKSS NGSSPTSVTV SGYDFSTISL
V
//
