ID A0A0V0V2T0_9BILA Unreviewed; 1059 AA.
AC A0A0V0V2T0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=mcm5 {ECO:0000313|EMBL:KRX57533.1};
GN ORFNames=T09_11416 {ECO:0000313|EMBL:KRX57533.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX57533.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX57533.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX57533.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX57533.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDN01000100; KRX57533.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0V2T0; -.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR CDD; cd17756; MCM5; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008048; MCM5.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF42; DNA REPLICATION LICENSING FACTOR MCM5; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01661; MCMPROTEIN5.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 807..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 890..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 942..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 981..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1021..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 338..543
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 1059 AA; 120459 MW; E5F14478E11E7BE3 CRC64;
MSGFDRAEIQ YSGQDEQKRL ELALTEEGTL KFAKSKFKNF IREFNYGSFA HIYRESLRNH
CKLGKMYLEV RLQDMRSYNS DLAYIFQKNP TEVLPMFEEV TKDVAEETTY QGSSEVNTLP
NMQVIITSDE NSQPVRSLQS KQISKVVKLR GIIVSTSQVR CKATSISIQC RNCQLTVNNI
SMQPGFDGYA LPRRCNSNQI GQQQKCPVDP FVILPDKCRC IDFQVLKLQE CPEDVPHGEL
PRHMVLYCDR WQFRFRYLTD RVAPGNKVSV LGIYCIRKQH KMTRREKAGK PSAGLRQPYI
RVIGIEVESS GLGRTAPHAL LLPEDEKQMR ELAAQPDIYE RIAKSIAPSI YGSEDVKKAI
ACLLFGGSRK RLPDGLMRRG DINVLLLGDP GMAKSQLLKF VEKVSPIGIY TSGKGSSAAG
LTASIVRDAS SRSFVMEGGA MVLADGGVVC IDEFDKMRED DRVAIHEAME QQTISIAKAG
ITTTLNSRCA VLAAANSVYG RWDATKGEDN IDFMPTILSR FDTIFVIRDV HSETRDLALA
KHVISVHVGA DSEAVRDEEA TDGEIPLATL KKYIAFCRTR CGPRLNRSAT RKLIHSYTRM
RNVPVAQQQK DLHIAYQKSS IPITVRQLEA LIRIAEALAK MELSPYATDR HVDEALRLFQ
VSTLAAASQG TLSGVEGFST KEDQEQFIRI ERQIRKRFPV GTQVAEHVVI QDFITQGYQE
ATIRKVIYAM VRRGDLHHRL QRKMLYRKSE MMEKSFYKVN VTDHFELPMQ SASFVTIVRQ
VGGVLTISAV TFIEAVFLSR RRFNAEMILL AAYFFALQLN GIGYLLNGIR FSNLRKRNYF
PMVPVKECLL THPDVTLSYF NYTLRPFLLV YLAVDRMCAV LLEVKNMKKV TTYGVISVYV
LSLFYVIGAW IETFLLRSDC MIKQNCIYWS AVPWYHQKFQ KYMHIFGLFA AVAIVIMALL
RAYVKRRKEV HCTTWSFAND YLAVTSRLSV IVFSEFIFRG LPLLWGCFVT RTISMYTVRM
TLYVFSDIIE AFYGVLYCYI NKDLRESIVS LCRLFGGCT
//
