ID   A0A0V0V4E5_9BILA        Unreviewed;      1069 AA.
AC   A0A0V0V4E5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Solute carrier family 12 member 6 {ECO:0000313|EMBL:KRX58406.1};
GN   ORFNames=T09_2136 {ECO:0000313|EMBL:KRX58406.1};
OS   Trichinella sp. T9.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX58406.1, ECO:0000313|Proteomes:UP000054681};
RN   [1] {ECO:0000313|EMBL:KRX58406.1, ECO:0000313|Proteomes:UP000054681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS409 {ECO:0000313|EMBL:KRX58406.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX58406.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JYDN01000086; KRX58406.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0V4E5; -.
DR   STRING; 181606.A0A0V0V4E5; -.
DR   Proteomes; UP000054681; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF53; K+_CL-COTRANSPORTER; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 2.
DR   Pfam; PF03522; SLC12; 3.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        78..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        391..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        496..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        521..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        554..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          80..253
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          358..636
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          651..774
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          784..873
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          996..1069
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   1069 AA;  120245 MW;  3FBD7353A1787EDC CRC64;
     MDKMETDEEI TTVKMNTIEE SPSKKASDAS MRISQKALAL YEEDGPANIN SVSMYLKSLS
     GVATDETGPK RAKLGTIFGV YLPSIQHILG VQMFLRLIWM VGVGGLIESF SMVFLCCLCT
     FLTSISISAI ATNGKIESGG TYFMLSRNLG PEFGGAIGIL YYLANTVETA MFLVGGAEIL
     LIYMAPDLPK FGSNDVTDPQ MFNNFRLYGT AFLILIFIIC CFGIKFVQFF APFSLACVIL
     SVLGVYIGAF VGHDTESTKL CLLGDSLLNP LYIMDENHTL ICNRTQQMND LYCINSTETS
     VKNCDEYYAN EEIHSETGIH QFSGSLLWSN LYSYYMYEGE SYPGRKGNSP FEVTQDIRSS
     FFVLLAIFFP STTGIMTGAN MSGDLRDPDK SIPIGTIAAQ LTTSFIYLSF VILYGGTMTR
     SMLTDKYGVS LEGKMVAAKL AWPNDWIVLV GSFTSCIGAS LQCLCSSPRL LQSIAKDNLL
     PFLNPFSVMT KYNEPFRALI VTALIAEASL MIGGIDYVAP VVQVFFLISY CFVNLACALQ
     TLLNVPNWRP RFRFYHWSLS VLGALLSLFI MFSTEWYYSI LVLLFFAFLY KYIEYKGAKK
     EWGDGIRGLA LSTAQYSLLR IEDSETHPKN WRPQFLILLK VDQEHSDTNY KLLHFASQLK
     AGRGLTMVAT VIKGSLANAE DRKNAERIKN LLKEDMKAAK VKGFTEVVLS EFVNENVSTL
     LQCVGMASLR PNTVFVAWPV SWRTSYEEHS HEFYSFLDAV CRSTAADKCF LMVKGLSMFP
     DVGDQLSGNI DIWWIIHTGG LLVLLPFLLK QDRVWRNCKL RVFTVAQSND NSVEMKRDLQ
     RWMYNLRIDA TVDVVELDES KVNEQAYERT QQMREHHSRP GLKDFSCWNI DTKNNDVANN
     LPKPEKLENA PRPIKQSISE QHLSMDPEDV KAHHPLASFI RKLSVKGQRA EHLQMAQAAG
     MPLSHIGYDN PNFEFCDKLP DDTKTQTDFE CLTFSSRQMV RKMNTALLLN NVIRERSSTS
     RLVVLSLPKP PQSKSEFKNY MEYMEALTDG LPRVLLVRGS GKEVVTIYS
//