ID   A0A0V0VQ85_9BILA        Unreviewed;      1609 AA.
AC   A0A0V0VQ85;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   08-NOV-2023, entry version 31.
DE   SubName: Full=Ras GTPase-activating protein gap-2 {ECO:0000313|EMBL:KRX65627.1};
GN   Name=gap-2 {ECO:0000313|EMBL:KRX65627.1};
GN   ORFNames=T09_13555 {ECO:0000313|EMBL:KRX65627.1};
OS   Trichinella sp. T9.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX65627.1, ECO:0000313|Proteomes:UP000054681};
RN   [1] {ECO:0000313|EMBL:KRX65627.1, ECO:0000313|Proteomes:UP000054681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS409 {ECO:0000313|EMBL:KRX65627.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX65627.1}.
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DR   EMBL; JYDN01000016; KRX65627.1; -; Genomic_DNA.
DR   Proteomes; UP000054681; Unassembled WGS sequence.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF125; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054681}.
FT   DOMAIN          690..882
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          1151..1193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1280..1347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1510..1541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1394..1497
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1151..1181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1286..1334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1510..1524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1609 AA;  175264 MW;  EE506269F7CD698D CRC64;
     MTSINLHQLM EKVKKVQLFS KQPGKGMVQG DRVGFVCLAS AERGSGASVC RNFGSNSSRV
     ELNFSAEQCG KVGGVDVIHV SSPCRHLSPT VICRSAVYAV VECKSRTLAC YASEQDARQA
     RKTTSCMPHC NGGKVVPTKA NPTTNAGGIF LLRHFQPSSS RHFLKSSSSS SSSGNLAFTS
     TPGSTFATAS TSLTPVCCEE KVFNRFKFHS PTNSGRFRSD FNVVQGRSSP LCIWSGPACD
     SFHLHPAVVS MFSVSLFSFC FCRHCLSRAT TAEAEIESQS NGNEKATSRS QSLTILPYHF
     KEWSNNNGDL SSKHPIEVDS WSLDRRPALH NNNNNSRTAA IGSGKLTMPQ PLPVMCTPES
     RRIPSHPTAT YSASAQLFTS STPTSSSSKL ANFFARPFRN SALKRTKSVS KLDRKRSNFE
     VPVKNGALSS TSAWNDLNKV RNSRSHDSLL ISSGGSSSAA ACLLPQTGGS NTNTNTNCCN
     TVVDLSNAGC SASSVHSSLL ATPNCFRITT VNSAGVATPK YFSCGTAAER DRWLYSLNHA
     MQPNRDQMRR KEKSLQVWIL EAKGVTAKRR YFCELALDSQ LYSRTSSKLN QDICFWGEQF
     VVNNLIKLDE VKICLYRESE RKKRKDRNTY VLNGQEKSAS KGETISLRVK ARFQSISILP
     LKAYSRLLQF LTDKYLETCL ALEPVLGVKA KEDFATSLIR IMHSQNLAKH FLCDLIMSEI
     KTLENDHLMF RGNSLATKAM EAYIKMIGEQ YIQRTLASFV QNVQDSGEDC EVDPEKLPAS
     ADIVKHQEAL LTTVHAAWGR ILNSFYEFPI ELRLVFHELR NRLADCGRGE LADNLISSSI
     FLRFLCPAIL SPSLFNLVQE YPYGKTARNL TLVAKTVQTL ANFTKFGAKE HYMEFMNRFV
     EGEWQHMRQF LRRISSPLCT NFPCKTTEWS GVIDLGKELS LLHSYLIEVL PEAVAKKSNW
     ENLNRLCKIV DDVSCAYNMS DISCCSSASP GSAGSSDYEN KGESPCVALS FDSSGDERSK
     ALTDDDLWYN AVDENIGLRR MGLMVQQSRL KQQLSLSKAN GFELGRSIST QSTGNNTALP
     TTITTTTAAT TTTADGNISA GQQQKQQLVA GGGDFSFGGC ATAAAACSDD ICYVDETTSL
     LFKSSSNAQN PITVEPSTVG TSDYNSLSNS PVGSADSSSG CSEKRLPAAD QASSSATMSN
     DISLAVANPL YSLQHVPVVW SSSAKTNKLD NSASTSSAAT ASSTTVVTTT SATATTITAA
     APASSASDVD RLLRRAPPLR PIDSVDTFHT ATNSSTSSSS SSSSSSTSSS TNHHTSSQME
     TVSSNNNNNK YPRPRTNPHF AGGHHHSRAM SLSIAAVNAV PPISCPIASA SGEQLNQRSG
     GCQQTAELLL AREVQELRIR LDESQSRLQQ AELRERTWKQ KYEESVPIKW SSDPVQPILH
     RLRLVEEELQ QEMNSSAQKQ QLIDEQRDRI QALLATNERL ALNLSKLQEK SASAEQMLLL
     TSLHKRPLDK SVSVNGHEEK KPTSTCGKFA PQRANQQQHR RSWDPCASSS ICFNSCSSNS
     SSSSSSSSSS SSPAATTADT NNVCCQATDV VNTVITAAAE FAQLKTTQC
//