ID A0A0V0VS56_9BILA Unreviewed; 793 AA.
AC A0A0V0VS56;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=UDP-N-acetylglucosamine 4-epimerase {ECO:0000256|ARBA:ARBA00031827};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE EC=5.1.3.7 {ECO:0000256|ARBA:ARBA00013175};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN ORFNames=T09_10201 {ECO:0000313|EMBL:KRX66330.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX66330.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX66330.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX66330.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC galactosamine; Xref=Rhea:RHEA:20517, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:67138; EC=5.1.3.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000014};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX66330.1}.
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DR EMBL; JYDN01000011; KRX66330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0VS56; -.
DR STRING; 181606.A0A0V0VS56; -.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:InterPro.
DR GO; GO:0003974; F:UDP-N-acetylglucosamine 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF00858; ASC; 1.
DR Pfam; PF01370; Epimerase; 1.
DR PRINTS; PR01713; NUCEPIMERASE.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 441..711
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 793 AA; 90001 MW; 0F9769621705F3CB CRC64;
MGSVNTWYSS LSLTERLLWA AVFFIATGFI LYCWTAIDWT FSDNGPGTTI LHVKKQSMHF
PPLLLCTRQP FNSKYIRQDP IFNNRFDKYA EKLISFSSAV KIQDLAGNEI EKLEKLYSTS
FNKTQERETE VNCFLPGDHF LKCIQIIKNV TSGAEILDVS SFCQNSSTLI TGFLNPCTVI
FPSEQKIPSD LGALKIELEL QKEQLTVSPA EFSGFEIYVG DLTVEAPFLP KITLKNNQAA
SLKLEIIEYI SSVSSKDFEE NRQALFKIET LKNCLYQSIK DECNCVLPFI CTKPDDSISI
PLCTVNDYKN CTASLGTNTL EIINHFDQFQ MPCLMKESTV NDIQFNCIAT RLPDIDTQTL
RYRATFSIYY DHFDYFQIKE AQLDSIKIFI LYGIPLAVVT ALLLITLKYN MVKRVGKRPY
SDDYLETSET SMYIMPTRKS ILVTGAGGFI GSHVVLELLE NNYNVIAIDT FDNCVRGERY
PVSLERVMEL TGKRFRFYDA DVLSKETLLE IFKQHRIDSV MHFAGLKAVG ESISKPLEYY
WTNVGGALTL LRAMKEEHIN NLIFSSSATV YGPPKQLPIN EEQEIGCGLT NPYGRSKFFI
EQILEDFHAA NTYAFEKEWN IISLRYFNPV GAHPSGLIGE DPTSMPNNLM PNISKAAAGK
IPALRIFGND YDTVDGTGVR DYIHVVDLAK GHVAALQKLH ENAGYKVYNL GNGKGYSVLQ
LVEQFERSCG RKIPYVIENR RPGDLAEIYC DNTLARNELN WTPKYDLQQM CVDTWNWQQK
NPDGYVSSEM ESE
//
