ID A0A0V0VUG9_9BILA Unreviewed; 1852 AA.
AC A0A0V0VUG9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Rap guanine nucleotide exchange factor {ECO:0000313|EMBL:KRX66659.1};
GN Name=pxf-1 {ECO:0000313|EMBL:KRX66659.1};
GN ORFNames=T09_7217 {ECO:0000313|EMBL:KRX66659.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX66659.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX66659.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX66659.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX66659.1}.
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DR EMBL; JYDN01000009; KRX66659.1; -; Genomic_DNA.
DR STRING; 181606.A0A0V0VUG9; -.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF249; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 71..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 152..198
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 486..551
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 616..735
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 736..807
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1067..1179
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1204..1433
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 345..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1518..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1697..1740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1799..1852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..441
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1852 AA; 204398 MW; B95B3523325D42A8 CRC64;
MEVKNDQLKQ HGEKNTHCSS ILLRFFISSL SAACKSSSYQ RIRKLSDNCS DRSNSVSVVN
TTLLFEKKLS LILFFVLLFF ATLEFCPILI LFYFFLVWGS LNFLIACWLI DASDFLLRMA
DTAVIEALRK PSKFRNLKEV QLVYFFLRRL DVFRGVDDQT LRTICQSARY EQFQQAGKFL
YKKGQRSFCW YILLSGAVFC DGRIYLPVES FGKRVRFSEH YRISDCILLE SSEMIVIDYN
STEPSVGSYP ESREQLPMAA TSLVVNRVPV ADGEPTTSST SSCSTSPSMC SSKVVLCRPI
HQTTASTSFA ASFKKACTVG EQQSSSCSVD EIEISTVAEI SSNLLPNRRL SSSQQQQQQK
HRHDGTLAMI RRSNSIRSSG SSSAGGRVSG FKPIAAIPST SSTTMSDDDF SGLPEISVDS
DDEDDDEAEL EEEDEEEEEE GCCLYAESSF TGHLRDLVRE CLEKLPTERT DDDIAILLDF
VQHMSSFASL PIYVKCELCR KMVFAVVDKA GTIVMKHGEQ LDSWSVVING EVEVVFPDGH
RYEYHIGDCF GVQPTEQVQF HQGEMRTLVD DCQFVLVAQA DYVQIISKLS DSYTRQLDSA
GQVVCEKEKR AFESRVGYVL TKAKPCKLIS ALFEDRRDCV VDPHFVEDFL LTYRTFVDNP
AEVLEKILAC FSEPSKREKV ARLVLLWVNN HFGDFESNAE MTNLLEKFDK MLEDEAMFNH
QQLLNIACSV KSRTRNVTYT RSNRDEVLHF SILGGTEKNN GIYVVKVAAG SAAERVGLKR
GDQIIEVNGH NFRNIARHRA LEVLRGSTHL SMVVKSNLLG FKEMLVADQC DAGALLAPVL
LQQAVATSKD GSSRRRMSPV QPRRSLVQLH QLGGVDGLPM PSLRPPPRQQ KHSLHLETQR
AVMPALVHAL ANTNTTSSSR TLARLNHAGK ESGGSGSRLG KLIKKLRQGS SSSALSLDAD
DDDVDNDHVD GHEPRVDDGG RKCSKQKIRQ TLDDCDATDE AVRRATLGRP TGAQSVSMPS
GVPLLGRRLK HSRSNPDLSS TANQPILPGG FGQMISQYYE PVRPQHPEHI LKVYRIDQTF
KYLSVYKETS AQNVVQLALQ EFGMCNNNNN NSGEGNDAVH SSSSSSTTTT TANGDEWSLC
EVTVTTDGLI KQRRLPAQMQ NLAERISLNS RYYLKNNNCP LPLVPDELAP DLLKDAQAQL
SCLHASIVAA QLTLQDFAAF ASIEPAEYVA NLFKLGGAPT RWPRLADFEQ SVNRETFWVA
TEVCKERNSI RRAKIVKKFI KIANHCRDFK NFNSMFAIIS GLEKPCVRRL HNTWDKISSK
YTKMLDNLQS LLDPSRNMSK YRQHLADASN DPPVIPLLPV LKKDLTFLHE CNPTWCDGGM
VNFEKLRMVA KEIRFVTKLA SAPYELSSMF ERSGNQAQLN DALLHMNTFE GGSSVATMKK
QHVQHRVPLS RKKLYEQALM VRRVKFYLTQ FEPISDESVL DKLSLELEPV TVTSGGGGGG
GAHSTSTGNL GVVTVASAGK RSQPSPSLSS GSSMSVTSSD CSRRCNGPKF GVESPHAVQK
MLSLVDHSRV RASSNNTRAI GIGSPPTSPG APLKAVRPAT AAVAHSLLYF GSNIHQHQHG
RFNNHDLNTF AIPPPLSSVV PVDLTCESSA VTSSITPSRL HGSASATSST DSVISSHQSD
LLPLSSSSSS YIPHAVSCDS TDSGHGSLDS PSMITGVGVA SSSSSSSPPS QRQSYPPRPN
TIALKAASNS TTHYDLYSTT TTGVVVSTKP FRSFEKAQQQ QQQQQQQQPQ QNFRFTAPQH
ENRASSSVAS STFLKQSQPL SSPLTIGSRR LATTADQSQS DTNNGATQVS RV
//
