ID A0A0V0VWQ9_9BILA Unreviewed; 1164 AA.
AC A0A0V0VWQ9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE Flags: Fragment;
GN Name=epha4-a {ECO:0000313|EMBL:KRX67871.1};
GN ORFNames=T09_10439 {ECO:0000313|EMBL:KRX67871.1};
OS Trichinella sp. T9.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX67871.1, ECO:0000313|Proteomes:UP000054681};
RN [1] {ECO:0000313|EMBL:KRX67871.1, ECO:0000313|Proteomes:UP000054681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS409 {ECO:0000313|EMBL:KRX67871.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX67871.1}.
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DR EMBL; JYDN01000003; KRX67871.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0VWQ9; -.
DR STRING; 181606.A0A0V0VWQ9; -.
DR Proteomes; UP000054681; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.1770; ephrin a2 ectodomain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR027936; Eph_TM.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF14575; EphA2_TM; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRX67871.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 17..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..273
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 394..499
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 502..618
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 743..1004
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 775
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX67871.1"
SQ SEQUENCE 1164 AA; 130158 MW; AA0BA814E106A820 CRC64;
LLPSFARHFH LADHRNFVAS ALMFSLTCCC WIFFLFTTQL QSIVHSKRVL LLDTTQLSYL
KWKTYSSSTS SQEGETNGKM TQLCSTQQQQ QQQQLSSGWS EESFANVKEG NNWRTYTVCD
FYKDSADHWL RTPYIARGNA RRLFIEMTFT MRACKEFPQT ALTCKETFTL LYHEADHDVA
NESTSLPWNE RSYRIVDKIT SNGARYAHSA AGEAETAAAM ATPIMAEHAS KTTVVRSVPV
SKNGVYFAFQ DEGSCTSLLS IKVYYQVCEE VLANFAWFDE TPAGPELTSI QETVGQCVDN
AKPTGESMPK FVCKADGSWD LLSGSCQCNA GFEAFDSHCS ACKMGHFKDV KGSVGCRPCP
LHSHTVSNGS VFCQCEPGYY RAQVDALSEP CTQPPSKPQN ARVEFVDQNS VVIAWNRPVS
NGGRSELWYR VDCRDCPAGI RYGSELMSSN RIHVTNITIS GLEPSTLYTV FVYAENDVSA
LLNGLPMYAV VEVTTTALAP VILSELRVES VAENEVSLAW HAPEVPLHLG SAYEPPTLQR
NRHGKPKLHV QYYLVDYAAR RSVATSRTGD HIRITTQQPH AFVQGLLADT EYGFKVRAYT
SRGWSAWTDT KWIRTSASSQ YNSVAGGLNP HGSSSTKYLY AAIGVLLFII SVLLTLAYRR
RLPFHLCGYN KQPSDLDVLE YKADQFSSDY NTIDIYNHKF NSAIVQLPRR SGSAYKPYVD
PLAYEDPKQA LREFANEIDS TAVALDEIIG EGEFGEVYKG KMCVPGCGVE VVAIKSLKTG
LSVKAKLDFL SEASIMGQFD HPNVIRLRGV ISRSEPAMIV TEYLENGSLD NFLKRNGDRL
DTVQLVRMLN DVASGMAYLS DKGYTHRDLA ARNILVDGKI CCKIADFGLS RELEGSTELA
YTTKGGKIPV RWTAPEAITF RKFTSSSDVW SFGIVVWEVL SLGDRPYWDW TNQEVVDAVD
QGYRLPAPHN CPATLYRLML ACWDKDYTCR PTFHQLRCML SDFLHCPDLM YSPTFLTSTS
QQNQQFYTLS ARVFAAGSFP YACSVEDFCR KLNLDRRFAQ VFHAHGVHRP VIVSELTSAD
LASMGLSRVD QEIVTRALVK FRLANANRMQ QSNAGTVGRR SVRVYEKSPV IASNTRVYTT
PGLVEQTTMD NNDSLPRRSN GFFV
//
