ID   A0A0V0VZF7_9BILA        Unreviewed;      1130 AA.
AC   A0A0V0VZF7;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|EMBL:KRX68850.1};
GN   ORFNames=T09_13732 {ECO:0000313|EMBL:KRX68850.1};
OS   Trichinella sp. T9.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=181606 {ECO:0000313|EMBL:KRX68850.1, ECO:0000313|Proteomes:UP000054681};
RN   [1] {ECO:0000313|EMBL:KRX68850.1, ECO:0000313|Proteomes:UP000054681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS409 {ECO:0000313|EMBL:KRX68850.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX68850.1}.
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DR   EMBL; JYDN01000001; KRX68850.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0VZF7; -.
DR   Proteomes; UP000054681; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054681};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        168..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        213..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        489..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        514..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        547..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          139..626
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          638..1130
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1130 AA;  126334 MW;  C71F94A88CF0AE8A CRC64;
     MSEQNFDNKV TEEAKKEDTA VVEPSAVSET LQTPKQGDDL VQNLRVRFKV ENEEKESASC
     THSTKLDENN VYINLEKEPQ FDHYRNALSI KRLVIPRRPS LKDLHYVAQT AEIHDPPDSS
     KCKPNAEYKE PRKLGWIEGV LMRCVLNIIG VMLYLRISWV VAQAGLGFGS LILLLSSAVV
     FLTALSMSAI CTNGKVRAGG TYFIISRSLG PEFGGSIGII FAVANAVSAA VYLAGFADTV
     IDLMKGYNAS IIDGAINDIR VIGWIAAVLL LGIVSAGLNF ESKAQIALMV ILIVSLINYL
     IGTFLTPTAL QRAKGITGYS FETMKENFYP DWRGETFFTV LAVYFPAATG FLAGANISGD
     LDEPEKAIPK GTILGVSITS VLYMAVLWLT GITCIRDASG SVSDLVNGTI TACAANNTCL
     YGLHNYFHIV EIEGAWAPLI TAGVFASTLS SALASTVSAP KCLQAVARDK IFPYIGVFGK
     GSKKNDEPIR GYLLTFAITV GILAIGEINE IAPLISNFFM ASYALINYAC FDASFAKSPG
     FRPAFKFYNM WLSLLGAIIC IVLMFFISWW NALITLIFIM LLYVYLVRRK PDVNWGDSMQ
     ANLYRNTVHN MLKLQSTQDH VKTYRPIILL LTGNPKKRSA LVDFVYNITK NQGVLLCGHV
     IQSDLHLKAL QARQQLPGLV IRWLKQRRIR AFYYSYICPK LDDGVLALLQ LCGMGKLNPN
     IMMMGYKKNW YQMDTAAIRE YFQLIHYGFD FHKAVGIVHL HSALTTEEKQ NPLNGGVEQS
     QICATNRLPR GNSMTTISIG SVDTLSMTND NFPVHHSRIE RESIRHDNAK FNSQNGSESS
     NADIKSMNLQ VNTENNCTSS EKLKLELCKE EKIGESPNLS SYFHDKQDEE TLDDLVFDDG
     DEENDRPLSS RFEKIKNFFL KSRHKPSCSQ EPIDNFRKRI KKAVIDVWWL YDDGGLTVLI
     PHLLTQAGYL ECAKVRVFTI SQNFEECEEE QKKMALLLSK LRIDFSDVTI FPESQIQPSE
     ATLALFNELV GKFKVQSREI YKPDDPEMVV MVDEKELEAL RGKTSQILKA RDLLLQYSRN
     SNLVIVTVPV PRKNFVSASV YLSWLELLCR DLPPTLLLRG NQDSVLTFYS
//