ID A0A0V0W1A1_9BILA Unreviewed; 1993 AA.
AC A0A0V0W1A1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Notchless-like protein 1 {ECO:0000313|EMBL:KRX69454.1};
GN Name=NLE1 {ECO:0000313|EMBL:KRX69454.1};
GN ORFNames=T06_7237 {ECO:0000313|EMBL:KRX69454.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX69454.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX69454.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX69454.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX69454.1}.
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DR EMBL; JYDK01000356; KRX69454.1; -; Genomic_DNA.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR PANTHER; PTHR46089:SF2; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 5.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00415; RCC1; 2.
DR Pfam; PF02204; VPS9; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00698; MORN; 5.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 4.
DR PROSITE; PS51205; VPS9; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 7.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 113..185
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 186..236
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 421..472
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 473..524
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1376..1528
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REPEAT 1618..1653
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1659..1700
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1702..1748
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1749..1789
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1876..1917
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1918..1959
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1960..1993
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 280..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1993 AA; 225277 MW; 4D23F7D01A052520 CRC64;
MKLNVHITIY YFVMKTCLWT RRRGHSLTCL NIDIPYQPDQ LTVYCRDCCA KEANVVFVKD
GIISEATLNV LVDEEGTVFE KRREPLQNVI LSGLRVQSIT FAYETFGAIT SSGNIYMWGR
SNYGQCGIIA ENVVKPEMSV NHVIVEVEIY AVDDYCMHGE RREPYDIQIV QLSIGGSEVL
AVDRNGALWA WGAAFQNGDS TAWQPICLPY RVPGLLGRRV LSVASGRTHH VALVEYIAGV
DELHGLDEYA FLGNSSNCFQ SNLPFVESCE HCQRGRRSVL TDGESTKSSS TDEPSSSPVG
RCPLGVKLSF ADDAECFLEP RPECKPRSKP QARQRKLYSD AHCRGDEVEL YELPRSKQQH
QASSSRLSFI SFDLIMPSSS SSSSLSEQTI ALDDSNALVG CVSGQSIIPG SSNLTGNICL
AELWTWGGNE FGQLGLNDFE PRCEPTRISG SSAFGIVKIA AGAEHSIAMS SSGEVFVWGS
NENRQIKVAD QRRVAVPMLF KAGSCAKVID IAAGEKFSAF LINGIDYRPE CYICGYDRSD
KDGTPVLRLY FPETCWPASL MCSDDYIICG CLEDTDAALC NVFYQIQFIL IRHVQILKQL
VDLINEIREE STFVDRFDES LFRRFAAGLR RYHLILANKS QSIKQYLFVL DVKATVEKSL
EILLDSRFQN FLKQLNADYL ILLSGDAFSL LKLNESVEKK LRYLCELNSV EHHKQSRLLQ
DVFFLPFTVF SDLHLIIAQF NGDDKFTKNT LKMLKSVDRV FRFYKNIASD TRKFRLKHAH
SSFLAEMNEK AQFLVKEFQR GQEPNEFVDV TENGRTVHCY LLAIFSGSFL VVTKSSFKNY
KFPLVWTHNV QDDANLLVKV IVPEGELMIK FRDPSGTKEF VIAFNNALLL YLSKPCSETP
LLCRPPLIRS GTHQFSAQNK TFPGAVYSGS WLLGKPHGNG HLTTKNNCVY GGHFRDGLMD
GYGEYKIVGE NGRWQFNKGQ WRAGVLSGLV FIEYSDGSSY EGYFENNVRH GHGVHRQGSI
LYVGAWQNDK RQGYGVSDEC RSKYLGMWEN DLKHGLGTLV TLDGICYKGV FEKGAFKNGM
MLLTDGTMAK GEFSDVECLN GKASIYFPNG DYLEGFLSGR LQEQLKISSG NFYKNGCCSS
DGIKSEKDKQ NNVHDFENSG FPPAEQKWND IFAHVYHQLN CAENTLLTAD TDKCWQSLVV
VCERFRKYFP THKLQTTSSS TNTADFIEKI PNYSMPCGEQ YYYMVKNYCF QAFQLQYHPL
GRLINGLSDI FNVSYSGVSV HSSLLVEAIE EIRSLLKRLY FVIKVLFPHL PGEQDMESFV
SEFNFDLPLS SCLTTYNTFL YDSYLELVYP NIFTLFVIKN EELDRVYWMN IRYVNSKSDV
MLLDYLGVEK QFWPVIFTDT SDLDKPLACA TARKKYYADA IDCFQRLSSE FFPSAKLKII
VETFEHINKC VSQGACVEQE LTAWTADSLV PVTTYVIVRA QIQRLGAEIN FVQDFCPQLC
NVGEMQYIKI KLYTTKLLFD VRRLAIRFQD ESGNPVGTVY DMPFNITPEQ LETVCNMEFR
KNEEPLKYSF FVHDLEIESS LEETIDMNKI NMEQVLLIRY QAHAIYKVQT VTRCTSSLPG
HAETVISALF SHDGRYMASG SGDRTVRFWD LNTELPQFTC SHTDWVLCLS WSPDGQRLAS
GCKEGKICIW DPETGKQIGK TLVGHKLWIT CLCWEPLHQQ GTARLLASSS KDHDIRIWDV
VLNQTLRVLS GHTASVSCIR WGGEGLIYSA SQDRTLKMWR VDKGILCRTF QGHGHWVNTI
ALNTDYVLRT GAFDPKDSGN DGTTLPATNP QELKNIALNR YKKFTRNEPE MLVSGSDDFT
LFLWSPSTSK KPLARMTGHQ QLINQVLFSP DGRIIASASF DHSIKIWCGK TGKFLHTLRG
HVQSVFQISW SSDSRLLVSG SADSTLKLWD ISARKLIVDL PGHADAVYAV DWSPRGDRVV
SGGKDKVLKI WRN
//
