ID A0A0V0W353_9BILA Unreviewed; 2184 AA.
AC A0A0V0W353;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dedicator of cytokinesis protein 1 {ECO:0000313|EMBL:KRX70005.1};
GN Name=DOCK1 {ECO:0000313|EMBL:KRX70005.1};
GN ORFNames=T06_14945 {ECO:0000313|EMBL:KRX70005.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX70005.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX70005.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX70005.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- SIMILARITY: Belongs to the phosphatidylethanolamine-binding protein
CC family. {ECO:0000256|ARBA:ARBA00007091}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX70005.1}.
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DR EMBL; JYDK01000312; KRX70005.1; -; Genomic_DNA.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00866; PEBP_euk; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 3.90.280.10; PEBP-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR008914; PEBP.
DR InterPro; IPR036610; PEBP-like_sf.
DR InterPro; IPR035810; PEBP_euk.
DR InterPro; IPR001858; Phosphatidylethanolamine-bd_CS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF01161; PBP; 1.
DR SUPFAM; SSF49777; PEBP-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS01220; PBP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 204..266
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 677..865
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1516..1939
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 2016..2092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2124..2184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2019..2041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2042..2092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2146..2164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2184 AA; 250233 MW; 1FA8B1B80F917B1F CRC64;
MFSCKVLSLN CPFSRGILSK FCYSSMSSLK DKFEEHEIIP DVVDQAPTQQ LQVKYKSGVQ
ADLGNVLTPT QVKEPPSLNW VATPGALYTM VMTDPDAPSR QNPKFREWHH WLVANIPGCE
INKGEVLSDY IGPGPPQGTG LHRYVFLVYQ QKSHLTDKEH GHLTNRSGNN RGGFSIRKFA
AKHDLGAPIA GNFYQAEWDD YVPKLYEQLG AKHNFRPNVV GNYLPLLIGD VVRVLQFSGE
WYYGCLDDDM TKVGVFPISF VEEKHTNFEN NELGSIAQTA VYSVLTVLKE WKKMCRESFE
RRGSIDIGKI FPMMKDIINW RSQIVSKKLS LEEVKKLNYK IALKIDLGNK MLGADVIVRD
IHGNELQTEN CSVAELHKHH LETAERIATE IEQSSWNTLS HLQRHSSRAE KFMQTKRSQS
NWNLLLTFVE FHHPYMNNGE LSFMLFDGRL WHGISEPAVV VVQQNNSTRF GVDPAPLQRF
IITVRMRIFI IVVVVVDLQV GNLCFVVQDL GTKDLDREKF WIIFLATKTG PFEWKDTLTY
RKTHVSSTTV RQTFAVAALD LTELLNQAFC TDPDAGTGAG VGAFSSTIDE QEERRIFLPL
RPLVDDSVEG MLRKIVDNKI GYNSELETKG DGFWLTLQPV FASLDELKHS QPHLFSNPFK
LVRKMGFPEV ISRDDVRNDL FVTLVSGDFT HCTGRSDKNI EVKVCLVDEL TNSVLPDSVV
NVGVAKETFY TSSVFYHQDR PKWFETIKFS IPVEIYGNVH IRFSFKHRSS NESKDRNDRP
FSVSFIRLKQ SNGTVIKDGF HDLVVYRVSS KIEENDFSYH TLPASKADLE MSGMEGTSSK
FHIQSPTGGF AISPKDFFTI CTTVCSTSLT QNVDLLGLLE WETKRVNLKS SLEALMKDEG
DRAGEEIVKA SLLYFLQDIL DVLFTVLISC NDHDQLVFDA LVYVIGLVGE RRYHNFKAVL
DSYLLLHFSA ALAYQKLIPI FKDYIDKVEE CSNKLLKTLK SLEYLMKFIV RSRNLYVQLK
GSNAGKERFH ELICSLFISL TTLMLYQTDW SLLCQGAALK YIPHIVVDVL AVFDARELAA
MMANFLKNVP RDRLTKQKLM CLQDLVHSEL IKKSGAHWNS FARIIVFQYC ILYSMYSEPR
AVLLPVILES VRNQIDDNEE LELCAQILTE IMNVLFDKHS TSGAHSSTLL FIMRTILRQV
VQVVVRLIEA GENLILGQYV ALLLAILEEL DACTYRCYIA EFATRTDLMD FLTELLMLFK
DLIRRPVFSS DWFQMIFVQN SIMLKILCYA ASTVKARFLH EKFEFQVCNS FFQTVVTFIT
QKLLQLEQYN VKKRKAILER FRDMRLTCAR ELVRSMWFSM NLLEKNQFIP SLVGFVLEVT
LIPVEEVRKL TIPIFFDMMV TEFYLRANNN STTTSTPLLG NFSYNSSVME FETEFIKKLD
SLVENDYGDA KYVDTFVKIM MQLCSSHTEA LRDEGIRFTK TVEHLMFRLL EFRNVRLYHN
NVNNCMSCTV SLLNFYYEIG HTELYIRYLY KLYELHMQRD NFVEAGLTMA LHAECLKWCD
SSVHALLAHS LFPDCVSQRE LKEKLFLKMI DLFDRGELWE KAIVVCQELQ HEYEHRTYEY
DKLANLLEKM SKMYRNILKH QRAEPEYFRV LFSGLGFPIF LQNTTFIYRG DGYERLADFT
SRIQAQYPNA TLLQTLQPPG EEIKRSNGQY LLINKVDPIY DDQIKTIPTP VKDSRILWYY
KCNDVQKFYF SRRISKKDCT LSKEWPVADE QENEFGLMWL EKTILVTSCR FPGILRWFLV
SSESQIELSP LEVAVDSMKA TISDLEKLIE EVERYSERAL KPLAAKLQGM LQPAVMGGIK
NYEKVFFTEE FMSKGSRKNL EMLELLKEQI ASQVPLLEKG IFLHAKFCSS DQREFHHLLI
DCFKEYKSHV EQHYGKQASL LPENSSLEIP KSNVLVYKQN LIDGSATSND GRYPFSSSIA
SRKSNSVREW QASTSAPWLL RTGVMTTLSG ATVPRRINSK EAAIRRKAAH STEKEIHQKR
HSNSSMGSTQ SAEMSCAGST IVLTEKLTTL RPPRPDSSFS KGSFKQQSNS SINRLTSSVE
KLSISASHSL VHSDSDEILL TNDRIDDHAA VPPPLPPRRD SGQIEIPDFN ASSVTFSPLS
PQRLPSIISG PRREKPLPPL PTTE
//
