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Database: UniProt
Entry: A0A0V0W4C2_9BILA
LinkDB: A0A0V0W4C2_9BILA
Original site: A0A0V0W4C2_9BILA 
ID   A0A0V0W4C2_9BILA        Unreviewed;       888 AA.
AC   A0A0V0W4C2;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   13-SEP-2023, entry version 28.
DE   RecName: Full=Methionine--tRNA ligase, cytoplasmic {ECO:0000256|ARBA:ARBA00018335};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE   AltName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
DE   Flags: Fragment;
GN   Name=mrs-1 {ECO:0000313|EMBL:KRX70434.1};
GN   ORFNames=T06_7029 {ECO:0000313|EMBL:KRX70434.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX70434.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX70434.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX70434.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC         methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC         Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC         ChEBI:CHEBI:456215; EC=6.1.1.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00001234};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX70434.1}.
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DR   EMBL; JYDK01000285; KRX70434.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0W4C2; -.
DR   STRING; 92179.A0A0V0W4C2; -.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07957; Anticodon_Ia_Met; 1.
DR   CDD; cd00814; MetRS_core; 1.
DR   CDD; cd02799; tRNA_bind_EMAP-II_like; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 2.20.28.20; Methionyl-tRNA synthetase, Zn-domain; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   HAMAP; MF_00098; Met_tRNA_synth_type1; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR041872; Anticodon_Met.
DR   InterPro; IPR023458; Met-tRNA_ligase_1.
DR   InterPro; IPR014758; Met-tRNA_synth.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR029038; MetRS_Zn.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR002547; tRNA-bd_dom.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00398; metG; 1.
DR   PANTHER; PTHR45765; METHIONINE--TRNA LIGASE; 1.
DR   PANTHER; PTHR45765:SF1; METHIONINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   Pfam; PF19303; Anticodon_3; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   Pfam; PF01588; tRNA_bind; 1.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF57770; Methionyl-tRNA synthetase (MetRS), Zn-domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR   PROSITE; PS50886; TRBD; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00209};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW   ProRule:PRU00209}.
FT   DOMAIN          726..827
FT                   /note="TRNA-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50886"
FT   COILED          634..665
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KRX70434.1"
SQ   SEQUENCE   888 AA;  101399 MW;  DF581C0C377EF4F8 CRC64;
     LKPIEMAGND KIIYNFEFSF PVPGERNILI TSALPYVNNY PHLGTIIGCV LSADVFSRYC
     RLRGYNTLYI CGTDEYGTAT ETKAIEEGVT PIQLCDKYYE LHREVYEWFN IKFDYFGRTT
     TKQQTEIAQH IFKKIYDAGF TTTKNVDQLY CEKCQRFLAD RFVEGECPFC GYEEARGDQC
     DKCGHLINAP ELKLPKCKLC SHPPIIRTSE HLFLDLPKLQ LNLEKYLEEQ WASSDCCWSH
     NAIAITKKWL KEGLKERCIT RDLKWGTPVP LENFSNKVFY VWFDAPIGYL SITANYSPEH
     WKKWWMDDKH VELYHFVGKD NVPFHSIIFP ATLIATNEQY CKVKNISATE YLNYESSKFS
     KSRGVGVFGN NARETGIPAD VWRFYLLYTR PESQDAAFNW DDFALKVNSE LLSNLGNFVN
     RALSFVERRF HGVIPEVDES LLDKDRLQVF IHNVNETLNN YIDCFDNLKL RDSVKCILNI
     SRLGNQYMQS ERPWELIKQN ERQAGSVLAI VANVVAILAA LVHPIMPEIS TTICKQLQLE
     KLVFCSSFQF LLKPGHRIGQ VTTLFVKFEK ETVEQFRKMF AGFQTNSEVA NVKKSPSSGK
     NICKAVKGSQ KYCEIFAEIE ETRHRISALK LFLTQRAKRR LAAENAELEK HLEKLKLDYQ
     ILMDRRELYS KLGLNTVSNE NISLENSNEK FTTTKDVVKD KKEKPKKKVA EKMDKVTASD
     QKNAVNISSL DIRVGLIKKA VKHPQADTLY VEEVDVGEDG VRTVVSGLVN FIPLEKMQNR
     FAVLLCNLKP AKMRGVESQA MVLCASTKDA VEILEPPEGA VPGDRIFCPG YEGTPEAQLN
     PKKKIWESVQ PLLLVNADGQ ACYANKPLRI VGKEGCLTAP TLRSVPIK
//
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