ID A0A0V0W4N9_9BILA Unreviewed; 913 AA.
AC A0A0V0W4N9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Major facilitator superfamily domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040619};
GN Name=pi4kb {ECO:0000313|EMBL:KRX70806.1};
GN ORFNames=T06_1102 {ECO:0000313|EMBL:KRX70806.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX70806.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX70806.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX70806.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX70806.1}.
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DR EMBL; JYDK01000266; KRX70806.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0W4N9; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0043625; C:delta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17340; MFS_MFSD1; 1.
DR Gene3D; 3.90.1030.20; DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR019038; POLD3.
DR InterPro; IPR041913; POLD3_sf.
DR PANTHER; PTHR23512; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23512:SF3; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF09507; CDC27; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 454..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 854..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 129..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 103445 MW; 8E47A93C5DF321A6 CRC64;
MNSRDRLTLD EAVFAEKRQV TFLWLSGQLN VHVNKAKELL KQYYIDHLSD KNITAVFYLS
GYKYLGVHRI LRIFHAREEQ LDLLKSHLDE ILSCHIYSVQ CCPLKDICGL FASDMQSIMP
SNDLLPISPL HTDYSESRTE QSKTNEQQPT AEKCKAPKVV ESTAEAEQFE SQRKQTEQKK
RKADDALLEA SGEKEKLQKI SSKKGKDRTK GRAVDKVEQE GVVHGNGSEN GGSLPSVHKT
VKRRKRNKKV EEEKLVHIGR GRSSTPSDDE NDQQNVKADL INDDEEEIKL HKKNQNTADN
GDLNSSGESE ANNPGPARIK RMKTTYKTYI DDKGYLVSKR IREMETVDVD KCDVIDKHTD
VADNKKLTST VKGPKKQTLL ANNISLKYTE KMDLKVLSES RVNESQQQLT AEENNEQQQH
VISECDLQNT CDTVDRDERQ ASPFLAAKFP HDRWYFRFYI LILVCFLNLG NYLIYDAPAA
LSSDLRKDMN VTISSYNLLY DVYSWPSIVL AFVSGVLIDR FLGLQYGGIL FALIILVSQI
VVSVGAFENL LWIMVFGRFI FAFGGESLGI IQNAYLVKWF RGKELNLVFG ITLSFARVGS
TISMNILKPI YNAIGQHFQS YTCLGYTMLA CVAFAAFSLS CSIVIAFHDR QHDRHLKSLQ
SAEAAEPSEQ DVVKIMDIIR LPLSLWILCG ICVSYYMTIF PFIANAQEFY ITKFHLTPES
ANLCNSLVYM MSIVMSPLFG ALVDLSGYNI YWMFVSIIMA LIAHILLIFT SLTPYVAVAI
CGFSYSLLAA SLWPSVSYVV AENAIATAYG VIPSVQNFGL ALAFLYIGEM LDRWGYFALE
LNYIVWLIGK MCELLSSFFN MCCLVSLLFA IALLFVDKAN GMQFYRREEI VYKSTKHVPN
DEMVQLEKQS LKH
//
