ID A0A0V0W4Z7_9BILA Unreviewed; 934 AA.
AC A0A0V0W4Z7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Major facilitator superfamily domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040619};
GN Name=pi4kb {ECO:0000313|EMBL:KRX70808.1};
GN ORFNames=T06_1102 {ECO:0000313|EMBL:KRX70808.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX70808.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX70808.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX70808.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX70808.1}.
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DR EMBL; JYDK01000266; KRX70807.1; -; Genomic_DNA.
DR EMBL; JYDK01000266; KRX70808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0W4Z7; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0043625; C:delta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17340; MFS_MFSD1; 1.
DR Gene3D; 3.90.1030.20; DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR019038; POLD3.
DR InterPro; IPR041913; POLD3_sf.
DR PANTHER; PTHR23512; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23512:SF3; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF09507; CDC27; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 454..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 647..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 826..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 129..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 106019 MW; 8E1EAC2240A48768 CRC64;
MNSRDRLTLD EAVFAEKRQV TFLWLSGQLN VHVNKAKELL KQYYIDHLSD KNITAVFYLS
GYKYLGVHRI LRIFHAREEQ LDLLKSHLDE ILSCHIYSVQ CCPLKDICGL FASDMQSIMP
SNDLLPISPL HTDYSESRTE QSKTNEQQPT AEKCKAPKVV ESTAEAEQFE SQRKQTEQKK
RKADDALLEA SGEKEKLQKI SSKKGKDRTK GRAVDKVEQE GVVHGNGSEN GGSLPSVHKT
VKRRKRNKKV EEEKLVHIGR GRSSTPSDDE NDQQNVKADL INDDEEEIKL HKKNQNTADN
GDLNSSGESE ANNPGPARIK RMKTTYKTYI DDKGYLVSKR IREMETVDVD KCDVIDKHTD
VADNKKLTST VKGPKKQTLL ANNISLKYTE KMDLKVLSES RVNESQQQLT AEENNEQQQH
VISECDLQNT CDTVDRDERQ ASPFLAAKFP HDRWYFRFYI LILVCFLNLG NYLIYDAPAA
LSSDLRKDMN VTISSYNLLY DVYSWPSIVL AFVSGVLIDR FLGLQYGGIL FALIILVSQI
VVSVGAFENL LWIMVFGRFI FAFGGESLGI IQNAYLVKWF RGKELNLVFG ITLSFARVVS
FFLFSHYVVI IYIYILNIKG STISMNILKP IYNAIGQHFQ SYTCLGYTML ACVAFAAFSL
SCSIVIAFHD RQHDRHLKSL QSAEAAEPSE QDVVKIMDII RLPLSLWILC GICVSYYMTI
FPFIANAQEF YITKFHLTPE SANLCNSLVY MMSIVMSPLF GALVDLSGYN IYWMFVSIIM
ALIAHILLIF TSLTPYVAVA ICGFSYSLLA ASLWPSVSYV VAENAIATAY GVIPSVQNFG
LALAFLYIGE MLDRWGYFAL ELNYIVWLIG KMCELLSSFF NMCCLVSLLF AIALLFVDKA
NGMQFYRREE IVYKSTKHVP NDEMVQLEKQ SLKH
//
