ID A0A0V0W525_9BILA Unreviewed; 4838 AA.
AC A0A0V0W525;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Protocadherin Fat 1 {ECO:0000313|EMBL:KRX70661.1};
GN Name=FAT1 {ECO:0000313|EMBL:KRX70661.1};
GN ORFNames=T06_3932 {ECO:0000313|EMBL:KRX70661.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX70661.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX70661.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX70661.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX70661.1}.
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DR EMBL; JYDK01000273; KRX70661.1; -; Genomic_DNA.
DR STRING; 92179.A0A0V0W525; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 27.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 29.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF310; STARRY NIGHT; 1.
DR Pfam; PF00028; Cadherin; 16.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 26.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 27.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 6.
DR PROSITE; PS50268; CADHERIN_2; 24.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4305..4326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4500..4526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..192
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 193..303
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 629..729
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 730..832
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 833..938
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 939..1045
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1046..1151
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1152..1266
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1363..1469
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1470..1631
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1727..1855
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1993..2066
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2078..2171
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2172..2278
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2279..2397
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2398..2515
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2516..2619
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2620..2835
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2836..2945
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3066..3171
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3172..3281
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3282..3400
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3401..3512
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3529..3624
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3892..3931
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3943..4117
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4154..4191
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4193..4229
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4238..4284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1500..1536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4349..4396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4680..4712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4775..4838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1525
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4375..4391
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4690..4712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4801..4817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4818..4838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3901..3918
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4181..4190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4219..4228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4274..4283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4838 AA; 536680 MW; D33D030B0CE9E774 CRC64;
MFDHPVISAQ WKHSMCAHWC EKDFELRYLS IFLPTREKKF SFPLYFGFVI CCLHAFHSVV
STTNSNSSTN AVTFEFTQST YVATILENTR RKVYVQPTSK MGIYLSPDLK GHVRYRIISG
DAEGFFKAES VVVGNFAYLR VHTKSLLDLS LNRESNAQFE LVVRASVREI KRETSARLLI
KVIDENDLAP IFQPDHYSAV VDELLEPFSV VVKVHATDAD EGLNGEVYYY LKEASSFFAV
HYVTGVLSSV RPLHSLAGRS VLLTVVAEDR AARLFADQVP ASRPNVALVN ITVRPTAAIE
PCQLSCQAVA SGCDVVQKRT CATCTLSRSP SSEIGDRIRL TGHYSEYFVA VRDDANALLY
HLMLNVAEIP SDSYAIQLHI DDSSGSELVS ADCKVTVNSG RCPSIANHPE KVNFTVDGTS
PDRTIVGFVS PLSLVDSGQY RWQMLKGVDS SSESFEIVQS TGLLVVRHLS AAGWYRFNVS
VESKTCKQKL DVEIELLVSG GNFHKPLFQL PPRCSHVAND GQLCHFEASD GDENGNRSLF
YSLVNTDAGR WSRLELGSVD GVLRLTGSKN SNQSTEVRVR VTDGQRPSRS GDLLLRFDSS
WQLVSFEPVE WPSIDDQRAP RFLHLPYPEV TVFENATIGL TVFQFQAVDQ DVGADGLVTY
SIIDGNEDGR WRIDPNTGKL TVQRSLDREQ VPRYNLTVAA SDGHWPEALV SLSSLLIHIG
DSNDQRPVFD RLLYQAEVDE NAALSSPILT VRARDQDLGS NGRVRYKLLT NGDQFALGSH
DGLLTVIGQL DRERRRRYDL LVQAIDSGSP PLSSFSRILI TVRDCNDNAP KCVVDEQRVS
VREDVPPYAL LTCVEAFDED DTEANRRLRF EIQVGQKFSI DAETGCLRVA DDGLDFHAQV
EHRLLVSVRD SGRPSLNTTC TVVVDVDMVN RNRYAPQFDS FAYNADIYEN EPPGTVVLSL
KAKDPDAVDW LKPSILYSIV GGDGWHYFAI GEQDGVIVSR IPLDRETRSY YWLTVEARDR
APVSLATRVD VFVAVKDRND NAPVPARPLY EADVVENSPP GTSIVQLNAT DFDEPRSPTL
TYSIREGNAQ SLFQIEPNTG LIYSGDRRLD REAVSVHQLE VEIRDGGSPA LTSRTLVLIR
VLDENDHAPQ FGSKLYSFNV PPCTKTGQLL CRIFAVDPDA GVNGTVSYSI VHQEGNNGGD
DGRVQLDPNS GQIYCSRVGS THWYGQLVSL NVEARDSGSP PLSSRTRVVI RFVPPADHLL
NAAPVLLSNA NLQLDLVENE PLGRVLVQFE AEDPDGDQVW FYSKQPLPSW LTLVPDTGEL
VLVDRSNLSN YNFTYAVTDG RLQTVGSVEL HATGVKYYRP ILPTPLYRID LLENTTVGST
VLTIEGYFEK PNIQQPITYS LVGNFVDKPA KFQLDAVSGA LVLAEPLLDR GEQQRRLLMM
MVEARSYHLK TSAFVQVHVL GGDQQPPKFL KSNYEVSLLV NSVIGTEIIQ LVAVDMNEYE
TKEEEEDDDD NDNDNEEEKE EVVENEGEKE NELSRSPPRT VLSYSIVSGN DRRLFHLDSS
NGLLTVARTL PVESAEHVLV IQVTKAGQRF LSDTASVTIR ISLASEAYVR FEQKSYHARL
RVDATVGSPI LLVQAEGGGH ITYHLDEHPI FALHPLSGCL SVRRPLINSN NSSVDVGEQF
KLTILASNLF GHSDTAQVTL TAVAAAAIDK LHNFGHVKFD QFRPRFLSDK FVGHILENQP
AGTVVTLRRP EGTNTSSSDV LRLSSLLQVN CDSCSFRLIE HWAKRLFQLD PMTGTLTTVV
PLDREQHHGA ELLLFNVLVE RIDGSNVSVG SSSLAADTAM VEIVVENVND CGPVFEPKSQ
QVRLVLPVAE GVPVVRVRAV DPDGPTLSYR LMEEAGQERS VLDAFHLDSE IGWLTVKNAS
LVLARMKLNF LVTDGEFDDH AQVDLRTVEV QELVVQDDSI QCIGSRLQAF ENGNRSDYIG
DVVVLNKRTK VDVIYSVLND RTVGHLFTVH PRTGALYTTG VPLDREARAQ WPVVVRASSL
RDAGRVLAQC LVLVDVLDRN DNVPVFVGAP YEFRVSVDRT DIGQLIGTVR AVDLDIGPNG
RVNYSCLTFD PPFSLNSSTG DLLLQRQFTS ADVGRRLKFR ITATDAGQPS LSTVADLIIV
IASSDMELGL FSKSSFRLSI FEGEENFFNQ ALVVVADHPT PRAGVVGYTM LNQREDDPNQ
QFALDFVTGE LSLQKPLDRE QIDQYTIRLK AVDHERNVTD FALVTVVVLD INDNWPQFNQ
STYSASLPED SPIGCPVVQL HATDLDQGDN ALLTFRLITV QSLGVDNSQR LEEEKEKSKF
KIHSSTGLIQ LTDALDFERC SSYLLEVECR DSGTLSKAST VRVLVSVLDV NDNAPVFAPE
NTFTIYEDNF SVGQVIGQLS ATDLDTVSRG KLRYGILYAA GQLEQLLFTL NAHEQGILRV
GPAMDQQFQV GNWLPEYRLQ AFVNDGLFSS RTEFVVRQIK CSSVSSSVVR CLPRFRRRFI
SISVSENELI GSTVTSVAIA DSSTTGHNHV HYVMLLGLGS GKFMVNPDTG HLIIADQLDY
EQRSRHQLVI GARMDNWGIV SVLHVQVDIV DRNDHAPRFV ASKFSILVSA SETVGTPLLR
LFARDRDQLD TARIRYSLVN RGRQPRDLAA SYFRLDPRSG VLSVRRPLTA LSGKNLRLTV
KATDGGSLED ETFVQVVIWS ELLPSLSREP RAESISLHVA EDAPVGTRFG RVRFRAYAGA
VARMVPLTDE TVAGWIGVEP NGTVYVAQSL DRETRAEFSF YVALVDELQT DHSAWISMTL
VNVIVDDVND NAPIFEANSV QLSVPEDLAP GSALLNLQAD DPDTAANGRV HYSLFQQADS
EAQSLQLFHI DSYSGLLTTT GPLDRETHAT HRLVILAADG GRPSLNSTLT VEIRLLDVND
QMPRFDRRQH WFNLTYADAV VGGTLIGTVV AVDLDAEPFN KLLRYYIVDA DHADAWLLFK
MVNGSLYLSD GFQWKFVFSD NTDTERQVFK LTVEVTDGKY SDQTQVYVNF EQNDKHRKRC
CHCGSDDDVI ELAVEENMPV GSVIYNLPDN CTSTTTTTTT TNSGGSWMRL QGTKHFAVDS
NAIVIAEPID RELSVNRRHL FYLRSDEDLC PLCERMFVVN VIDVNDNEPL FKRPVYETSV
QEHENVTYPA FVVQVHAVDR DFGPAGRVRY RLQSDWNGLF RIDENSGVLS VTEPLDREQQ
HEYSIVVLAE DCAQETGAKS LSAQCSVLLT VLDINDNAPE FTELVYKAEI AENARLGDRV
VTVKAFSRDV GLNGEIVYQL LPNNDGRRPS PLLAQSKIPF AIDSQTGVVT VNDSIVACLS
AGQRQIQLTV VARDRGSPPL SNSSLLIVDL VEVNDHRPQF DRQEYNVAIR ENMAIGERVL
QVSATDLDRG DNGLVAYRLF GSRDDNDASN QPLPPFAVMD DGWILVNGST DRERMARWQF
QVEAYDFGKP SRSALTTVTV DLVDVNEHPP TVVDCNTTTV HVKRPLVSGM ILHTLTVDDF
DQSDQQSKFH FQLLDHDDND NISSSSSLFR IDPDRGILQL VAPTLNHDHY VIQVKISDNG
EPILSTICKF DIRLVDESKH RPTVEDFHCE LWTHVGEFTG GIIGQLRPTD QDPLDKLTFA
LVQHRGDDTF NVDSDDGRLL ASADLISAGL YLLNVSINDG KYSTFAKVTI DVHHISREML
NSAVTLQVVI AKDGQRFLQQ SLKRLSRFLA KLVGVRVKYV HIFSVQPSVG DDIGQQNNVV
LSVRGGQMFD LLVAVQKSKQ EFYKASLVSD RLVRKAGEMA SVSGMGRVKV VRAACGRADC
QNGARCRDVL LIDDAGPVTL LTDDFSFVSP MHRQTAECLC PAGFGGTYCN QKIDKCASNP
CQAGMVCIAD DTVTGYHCAC PFDNDDLSNC HPSNCRSPPC TGKLLFSFGG NGFVWFAMDS
SFDYYMDVRM EVKTSIRFAV LLFSKGRNDF HQLEIKNGFL QYRFDFGSGQ AIVRNSVVLS
DDHWHVVRLV KRDRQVSLTV DEKQNRLQLS GSSSVLNFFN RGSHLYVGAE VTDAGNRSSV
KNAFLGCIRG LEINGEVKQV SNNAGVELFG NIQLGACING DIDDDDDQDE DGSDRQYPPP
HLMNNRQEVE EGKVHGACSI QPCLNGGSCV GRGSFGFTCL CPARYFGTYC EIDRTPCLSS
PCQNGATCIN LFNDFQCRCS KLFIGRTCSE RKKSAEVEED ICASSPCANG GQCLLNDHIH
LLNSGDESRF ICNCTAGWTG PTCSLPSDSL LHAPNLIGGV SLMEFVGIVI LLVLLALVAS
TVVVLCRRRR RRLHYRKVRV KRTRHEEILL DQRQPLHPRR RSARATAAAA VHGRDEPPPQ
PPPPIPPRFP RSFQPHRGSK LSNFESALST GIPTVQVRPL SFMERPAGDS PSAVRLLIHE
QAAASYGSAA EELELLGDQA TNKGMMGETK ASNCFNTADD DWKTALDNID SDSLDKLKRL
AGIATGSLVL GLFVVFILHI LFASFLKMKV KQTKMISVLM SIPIQLQLHD QLRKFTSRTS
RPMQTAIVTF HWDYSDWTNT IGNTGYPSLG HITDMNTDDD DDEANTLPRG ICRLEEDTDY
EYAFHSGSDD DNNETERVGI GLGNEIREQI RAIGLLNDEI NKVDQLKKEP PQSCIRRYLP
MFTPPSSGSE RRRLIDSPQP RSTATTTTTT TTTMTTNPNF NTTVHDYSDV PLLPRDSDCE
SVESIPLVHL NSSANKFNSS MSSYFKGNKH VDKRLPKSVN NRSQSDVSQV CELEDEEEDN
VVMKNAEKEH EEEEASDSPP PASSSQGSMK KCDSTTTS
//
