ID A0A0V0W6P6_9BILA Unreviewed; 873 AA.
AC A0A0V0W6P6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE RecName: Full=Vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|ARBA:ARBA00017947, ECO:0000256|PIRNR:PIRNR007949};
GN Name=VPS16 {ECO:0000313|EMBL:KRX71345.1};
GN ORFNames=T06_16267 {ECO:0000313|EMBL:KRX71345.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX71345.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX71345.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX71345.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport and
CC autophagic pathways. Believed to act as a core component of the
CC putative HOPS and CORVET endosomal tethering complexes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR007949}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007949}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007949}. Note=Cytoplasmic, peripheral membrane
CC protein associated with late endosomes/lysosomes.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX71345.1}.
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DR EMBL; JYDK01000245; KRX71345.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0W6P6; -.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|PIRNR:PIRNR007949};
KW Lysosome {ECO:0000256|PIRNR:PIRNR007949};
KW Membrane {ECO:0000256|PIRNR:PIRNR007949};
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 54..448
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 547..853
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 873 AA; 100495 MW; D524187470B797D5 CRC64;
MCFIHNSIIN LLTVNTSRYC KSANNFPVFI CHFNVNSDNE ILQICKSLLM FCQTADWFPL
GTETFQKLKI YDLTWNIGKF NLNEYAACSY GGNIAILNDD AETRRKYVEL YNPSGKFISK
FIWRADDLLY MNWTRAEDLI CVQSSGKVSV YSQSGEEKLR NQFNMGKEAL EMKIISCQAF
HSFGNATGLA VLCRTLRFYL VNDVEQTKLW RTREVHGKST IPSCWVVISK ERQTKVLCAF
DNEIYVLSRE LASEQIIPPF TTPVRKYTSV ILSPDKEKLA FMSDESLVQI CSSDFKIFHC
EFFCTPCTDF AIFVGEGNSY SLTGLVNDTM NFSCDDSSFA VCQEPDGLRI YSRNKHEFIR
CVNKSAVEIF RVGSLSPAAF LVVAHAEYTA NNYKAFEYIR LILDQLPDAI QTCIEAATHF
FDPSIQKRLL LAASFGKSFV PTAEVDAYTN ACRTLRILNA IREMNFAMPI SYLQLKSLTL
PNLINRLIAR EQYPLAVSCC RCLRLDSGIG VNRVVMHWAS KIVCDKSISD ERIVDRIKEK
STEFPDISFA SIAEIAAQHK RMDLATKLLN YEKNLERQVF MLMKLNRNEK ALSKAAQSKD
PELIYSVILH LRESFEKISD LSLIMRNFPI PFTLYKSFVR EISADNFRFL LEETDDFIGQ
ALYHLKASNA PVFDITDKVE TLQLAEKCFR IAKENFCVSQ LCDNIKLLKL QEELAEKFND
SSSLVDCSLQ ETIEWLICAN EWNYVEMAKK EFKISDRQLC WWKMRALAKA SRWQDLENFA
KHKKPLIGYL PFIEECMKYG NREEARKYFS KVTADDRLEA LIILKNYESA ANLAIQQRNE
EALNRILSLC SANKLPEYDA ILSLKKQWKK QKK
//
