ID   A0A0V0W8A4_9BILA        Unreviewed;       447 AA.
AC   A0A0V0W8A4;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Legumain {ECO:0000313|EMBL:KRX71443.1};
DE   Flags: Fragment;
GN   Name=Lgmn {ECO:0000313|EMBL:KRX71443.1};
GN   ORFNames=T06_5393 {ECO:0000313|EMBL:KRX71443.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX71443.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX71443.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX71443.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C13 family.
CC       {ECO:0000256|ARBA:ARBA00009941}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX71443.1}.
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DR   EMBL; JYDK01000241; KRX71443.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0W8A4; -.
DR   STRING; 92179.A0A0V0W8A4; -.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd21115; legumain_C; 1.
DR   Gene3D; 1.10.132.130; -; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR048501; Legum_prodom.
DR   InterPro; IPR046427; Legumain_prodom_sf.
DR   InterPro; IPR001096; Peptidase_C13.
DR   PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR   Pfam; PF20985; Legum_prodom; 1.
DR   Pfam; PF01650; Peptidase_C13; 1.
DR   PIRSF; PIRSF019663; Legumain; 1.
DR   PRINTS; PR00776; HEMOGLOBNASE.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..447
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5006871570"
FT   DOMAIN          341..437
FT                   /note="Legumain prodomain"
FT                   /evidence="ECO:0000259|Pfam:PF20985"
FT   ACT_SITE        143
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT   ACT_SITE        184
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KRX71443.1"
SQ   SEQUENCE   447 AA;  51532 MW;  6F804B902F0D50D6 CRC64;
     LFNMLSIWSF LLLLVLFKST TLVISHENSS QKWALLVAGS NGWYNYRHQA DICHAYQILR
     KHGIPDSNIV VMMYDDIAYN EENKLSGKII NHPHGVDVYQ NDVNVSNFMK ILLGKEKEMQ
     HIGSGKVIKS GPNDHIFINF VDHGGKGILC FPEGEMTIGE LNKTLTEMHR LKKYGQMLIY
     IEACESGSMF KNILPNDIKI YATTAANARE SSYACYFSEE LETYLGDCYS VNWMENSDQE
     LLWMETVREQ YNIVKFETNT SHVSEFGDRS VSEDYLSDFQ GEEIFLKFGN SLFLKLLQQQ
     PQNRRPPNVH LDAVSSRDVP LEILKRKVSK NGYESDAAQQ NLHSLLMKRK YVDEFINQMV
     VEISKHFHLN HDAMLTKRVA DDVMDFDCHT KLVHHFSRNC FSFSKNTYAL KYAYVLTNLC
     NTGIPVDKIL IRMEKSCKTA KKYSNIV
//