ID   A0A0V0WBL4_9BILA        Unreviewed;       474 AA.
AC   A0A0V0WBL4;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=cysteine desulfurase {ECO:0000256|ARBA:ARBA00012239};
DE            EC=2.8.1.7 {ECO:0000256|ARBA:ARBA00012239};
GN   Name=NFS1 {ECO:0000313|EMBL:KRX72965.1};
GN   ORFNames=T06_15211 {ECO:0000313|EMBL:KRX72965.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX72965.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX72965.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX72965.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC       aminotransferase family. NifS/IscS subfamily.
CC       {ECO:0000256|ARBA:ARBA00006490}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX72965.1}.
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DR   EMBL; JYDK01000190; KRX72965.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0WBL4; -.
DR   STRING; 92179.A0A0V0WBL4; -.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0031071; F:cysteine desulfurase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0044571; P:[2Fe-2S] cluster assembly; IEA:InterPro.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   HAMAP; MF_00331; Cys_desulf_IscS; 1.
DR   InterPro; IPR000192; Aminotrans_V_dom.
DR   InterPro; IPR010240; Cys_deSase_IscS.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR02006; IscS; 1.
DR   PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR   Pfam; PF00266; Aminotran_5; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673}.
FT   DOMAIN          77..438
FT                   /note="Aminotransferase class V"
FT                   /evidence="ECO:0000259|Pfam:PF00266"
SQ   SEQUENCE   474 AA;  53329 MW;  5D4C8067C17D6E4A CRC64;
     MKFYNATLQK CTLWYFAKKC FTEMDLKKQL CNLYFMLAML HLITVRFTGT TSDESSDLNR
     PNNVLSEREI VRSRPLYLDA QATTQTDPRV LDAMIPYCLN LYGNPHSRTH KYGWESETAV
     ETARERVARL IGADSREIVF TSGATEANNL AIKGVAHHYR KRKNHIITTQ IEHKCVLDSC
     RKMEREGFKV TYLPVQKNGL ISLENLEKAI NDMTVLVSVM TVNNEIGVIQ PVEEIGKMCR
     QKGVFFHSDA AQAIGKIPVD VNKFNVNLMS ISGHKIYGPK GIGALYIRRK PKVRLEPQMS
     GGGQEKGFRS GTVPVPLVVG LGTACMICQK EMQFDIEHVT RLSKRLCSKL REALPCIVFN
     GDQEKRYPGC VNISFAYVEG ESLMAGMKNI ALSSGSACTS ASLEPSYVLR AIGVDEDVAH
     SSIRFGIGRF TTEAEVDYAV ERCIAEVKRL REMSPLWEMH QEGIDLKTVK WVKH
//