ID A0A0V0WGN3_9BILA Unreviewed; 1312 AA.
AC A0A0V0WGN3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Neuropathy target esterase sws {ECO:0000313|EMBL:KRX74339.1};
DE Flags: Fragment;
GN Name=Pnpla7 {ECO:0000313|EMBL:KRX74339.1};
GN ORFNames=T06_13124 {ECO:0000313|EMBL:KRX74339.1};
OS Trichinella sp. T6.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX74339.1, ECO:0000313|Proteomes:UP000054673};
RN [1] {ECO:0000313|EMBL:KRX74339.1, ECO:0000313|Proteomes:UP000054673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS34 {ECO:0000313|EMBL:KRX74339.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX74339.1}.
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DR EMBL; JYDK01000149; KRX74339.1; -; Genomic_DNA.
DR Proteomes; UP000054673; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 3.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 3.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001423; LysoPLipase_patatin_CS.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR14226:SF29; NEUROPATHY TARGET ESTERASE SWS; 1.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF01734; Patatin; 1.
DR SMART; SM00100; cNMP; 3.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 3.
DR PROSITE; PS51635; PNPLA; 1.
DR PROSITE; PS01237; UPF0028; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 168..235
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 396..497
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 514..615
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 863..1029
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRX74339.1"
SQ SEQUENCE 1312 AA; 150092 MW; FF0E62ACD146890A CRC64;
LVEILTKDGC IHAVHSATLR GANNYPTINH FKNLKIITIG MGCIFITWVI NRFMRLNVAT
SSGTKYPVTF SRKSSFNYRF RKRDRMLFYG RKLMRKVTSA VINGDKKQKL RKRDRVFRFA
SKFLRPQKKD STARPIRRPP DAFLEADTSL PVSPKSVQLL NMLKSIRILG HFEIPFFLDV
CKHIETKRFA ADQFVFKDGE IHDCIYIVES GRLSLFIKDE KFDFEVKSVG RGDSLYCSLN
ILDMIKNQAR PMKNVFAKAT EESVVLQLKS SVFNDIFDKY PESWTRTVQI ILLRFQRITL
ATLYRYFGFT SELSKTVQLY RIIFLLLYGL NFQSIRAVSK LSPLQEQSCK DFREIKSENE
GATPEDCTAS ENAFPTFGVS TTDDDSDIFQ VAIEELAKLF GMKEASFLVD KVKVEKFEPG
IMIVRQGSNE LQLFYVVSGM LELLLESQED PDVLLPISIV QTGDVIGGLS VLSGEPSFFA
VRTRSYCQLA IVERKSLYEC VTFLNRIISE YPRVVVNVAS TAVESYSDFV KEFDMAVEWE
ICESGKALYK QNEQADALYV VLSGRLRSVL TREPGTREVL NEHGRGDVVG LVEIWTLRRR
STSVIAIRDT ELCKIYATLM NFIKNKHPQV LSNIIRLLGH CIIEQQQQTV SAVHREPLAH
VSNLNTIAVL AVSDEVPLTG FTVELWNALN SITPTELFSS YTLQDMLGPT ALDKVNEYQI
ITWLNQQEDG NSIVLYQCDV ELTTFTSLCI RRADCILIVA NGEQEPMVGE IEKELENLTV
RAQKELILLW HDSTDRPRRT AEWLDLHGWV SSHYHVRFRD RVFKQRNPRR MLRYKERIIR
RCDNRHTDIA RLARALTSTS IGIVLGGGGA RGAAHVGIIK ALKDHGIPVD IVAGVSIGAF
VGGMYCLDSD VPKLIMCAKQ AFKEAASFWA RLFDLTYPVS ALFTGKALNR LLKSVFNDVE
IEDLWIPYFN VTTDITSSEM RVHRSGKLWR FTRASMSYIG ILPPLCDPLD GHYLVDGCYM
NNLPADVMRS LGVRTVIAVD VGALTETEFT NYGDYLSGWW ALWKKYNPWA SPVRVMSMAE
IQSRLAYVSC VRQLEEVKKA PYCHYVRPPI DKYQTFDFNL FDEIFNVGYW HGKTLLEEWK
SSGKLHELFD GRSANLSKFA QREKFKRGFA FTSAQSFTDL AAMVSKIHRP FETSLDEISE
EEGDDRIPLD LIHTTSSSSY RHCLQKKKYS IIVIFRYYNN NLKMSGHRVV ISRDDVDQFD
KLLEKSGCAK EHYVLQDCYA EHKDWRKCKK EIDALRKCMK VEDRTESADN AT
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