GenomeNet

Database: UniProt
Entry: A0A0V0WI59_9BILA
LinkDB: A0A0V0WI59_9BILA
Original site: A0A0V0WI59_9BILA 
ID   A0A0V0WI59_9BILA        Unreviewed;      1391 AA.
AC   A0A0V0WI59;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   08-MAY-2019, entry version 24.
DE   SubName: Full=DNA replication licensing factor mcm7 {ECO:0000313|EMBL:KRX75336.1};
GN   Name=mcm7 {ECO:0000313|EMBL:KRX75336.1};
GN   ORFNames=T06_11932 {ECO:0000313|EMBL:KRX75336.1}, T06_9739
GN   {ECO:0000313|EMBL:KRX76164.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX75336.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX75336.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX75336.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01116611};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide,
CC         peptide and isopeptide bonds formed by the C-terminal Gly of
CC         ubiquitin (a 76-residue protein attached to proteins as an
CC         intracellular targeting signal).; EC=3.4.19.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01117307};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00536536}.
CC   -!- SIMILARITY: Belongs to the MCM family.
CC       {ECO:0000256|RuleBase:RU004070}.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|SAAS:SAAS01045498}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRX75336.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; JYDK01000125; KRX75336.1; -; Genomic_DNA.
DR   EMBL; JYDK01000107; KRX76164.1; -; Genomic_DNA.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0036459; F:thiol-dependent ubiquitinyl hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd01874; Cdc42; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR037874; Cdc42.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR008050; MCM7.
DR   InterPro; IPR018525; MCM_CS.
DR   InterPro; IPR001208; MCM_dom.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR027925; MCM_N.
DR   InterPro; IPR033762; MCM_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR11630; PTHR11630; 1.
DR   PANTHER; PTHR11630:SF26; PTHR11630:SF26; 1.
DR   Pfam; PF00493; MCM; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   Pfam; PF14551; MCM_N; 1.
DR   Pfam; PF17207; MCM_OB; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   PRINTS; PR01657; MCMFAMILY.
DR   PRINTS; PR01663; MCMPROTEIN7.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00350; MCM; 1.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00847; MCM_1; 1.
DR   PROSITE; PS50051; MCM_2; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU004070,
KW   ECO:0000256|SAAS:SAAS01112253};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054673};
KW   DNA replication {ECO:0000256|SAAS:SAAS00619122};
KW   DNA-binding {ECO:0000256|RuleBase:RU004070,
KW   ECO:0000256|SAAS:SAAS01112237};
KW   GTP-binding {ECO:0000256|SAAS:SAAS00466048};
KW   Helicase {ECO:0000256|SAAS:SAAS00536375};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00536681};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01044152};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU004070,
KW   ECO:0000256|SAAS:SAAS00095925};
KW   Nucleus {ECO:0000256|SAAS:SAAS00536508};
KW   Protease {ECO:0000256|SAAS:SAAS01044292};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673};
KW   Thiol protease {ECO:0000256|SAAS:SAAS01044269};
KW   Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01044331};
KW   Zinc {ECO:0000256|SAAS:SAAS01044373};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS01044352}.
FT   DOMAIN      338    534       MCM. {ECO:0000259|PROSITE:PS50051}.
FT   DOMAIN      755    815       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   DOMAIN      870   1189       USP. {ECO:0000259|PROSITE:PS50235}.
FT   ZN_FING     755    815       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
SQ   SEQUENCE   1391 AA;  158054 MW;  717F39D327AAE470 CRC64;
     MVVRRDYESE KTKIRDFINN FYVQDNDGRG KIYVYLQKIT SLANRQTVAF VVDLNDLLEY
     DPDLVESVVN NTRRYTELFS VVVEDLIFKA LQGRAPPIKD CYDEFVNYRI NFELQKQRDR
     GETISNPSAA YPPDLLRRFE VYFKALSNEK TYSVRQVGAE QIGKLVTIRG VAVRVTEVRP
     LITIVTYLCT ECGCEIYQPV TGPNYTPAEC CPSKECKENK TRGRLIFQIR GSKLVKFQEV
     RIQEHSDQVP VGHIPRSLTI HLRGENTRLI NPGDHVHITG VFLPKLKTGF RQLIQGLISE
     TFMEAHHIVC LSKTNDEINE DHLRLSEDDI KLMAEDDFYD KLTYSIAPEI YGHEDVKKAL
     LLMLVGGVDR SINVCLMGDP GVAKSQLLSY VDRLALRSQY TTGRGSSGVG LTAAVIHDQL
     TGEFTLEGGA LVLADQGICC IDEFDKMMDT DRTAIHEVME QQTVSIAKAG IIATLNARTS
     ILAAANPAYG RYNPRRSIEQ NIQLPAALLS RFDLIWLIQD KPDRENDLKL AKHITFVHAH
     SKEPPSQFKP LSMRLMRAYI ALCKRKHPTV PESLTENLVS TYVEMRKDAK SDKDAMFTSP
     RSLLAILRLS TALARLRLAD EVVEDDVMEA CRLIEVSKES LRPQREGRGR IIQPVDQVFA
     ILRELLVQQP DKSGEISMQD AINRCIRKGI DTHLLEDCLE TYEEQGIFES KDEKCCHWEE
     VKEKDPILFK KFRKICSLII YPCNRRNLHV QAMFMSCQVC EIRDSFIFAC IDCATVGCLK
     NNHFEEHSKE KEHVFGVNII TGHVLCFRCQ SIISDAKLNS IICKVNCRYR QIYGLNPVSY
     EKVTDDPPAE LVPYLRAKRL VNPPSLLGVR GLLNLGNTCF FNTVLQVFLH TARVQEYFLS
     DCHPPCGKPL CLICEIGTVM QERLFVERPP IAPARLLASL WKAAPEIAYA EQQDAHEVYL
     ALMNGIHQSS DGKDFGEVCS CIAHKVFSAR HKCDVFCICC HRVTSKVEPC FNISVDILDS
     AEGVSLMKCL DRFTDAEKLI LHAYCCYCGC ECAIWKQVTF LDFPNVVCFH VKRTEKSRHR
     FQKVKTWMHF PEILDLMPYY RNRLKEIDPT VDLPLIEECP WLKLLATVEN QYVLYAVINH
     AGQTETGHFT CFLRPNDGQW YHCDDNVITP ATDSEVYDSE AYIWHDQAAG YSILEHELAA
     MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG
     QEDYDRLRPL SYPQTDVFLV CFSVVSPSSY ENVKEKWVPE ITHHCAKTPF LLAGTQIDLR
     EDSSVLDKLS KNKQKPITVE QGEKLAKELK AVKYVECSAL TQKGLKNVFD EAILAALEPP
     QPEKRKRCFI I
//
DBGET integrated database retrieval system